Chen Heping
Name: Chen Heping
Title: Professor
Email: chenheping@ncu.edu.cn.com
Hometown: Jinxi, Jiangxi
Supervisor Type: Doctoral Supervisor
Courses Taught: Pharmacology, Drug Toxicology, Biopharmaceutics
Personal Homepage:
Research Directions
Primary research focus is cardiovascular pharmacology, specifically centered on the discovery of new target molecules and novel mechanisms of action related to myocardial ischemic injury and protection.
Education
· 2001–2004: Jiangxi Medical College, Postgraduate/Master, Pharmacology
· 2006–2009: Sun Yat-sen University, School of Pharmaceutical Sciences, Postgraduate/PhD, Pharmacology
Work Experience
· Jul 2004–Oct 2009: Nanchang University, School of Pharmaceutical Sciences, Lecturer
· Nov 2009–Nov 2014: Nanchang University, School of Pharmaceutical Sciences, Associate Professor
· Dec 2014–Present: Nanchang University, School of Pharmaceutical Sciences, Professor
Academic Affiliations
· Member, Committee of Anesthetic Pharmacology, Chinese Pharmacological Society
· Council Member, Jiangxi Society of Cell Biology
· Standing Committee Member, Jiangxi Provincial Basic Pharmacology Professional Committee
· Communication Review Expert, National Natural Science Foundation of China Projects
Honors
· 2011: Young and Middle-aged Backbone Teacher of Jiangxi Provincial Universities
Major Achievements
I. Major Scientific Research Accomplishments
Has presided over five National Natural Science Foundation of China (NSFC) projects, one Jiangxi Provincial Natural Science Foundation Key Project, two Jiangxi Provincial Natural Science Foundation General Projects, and one project funded by the Department of Education. Has published over 40 academic papers (including 29 SCI papers as first author or corresponding author) and contributed to the compilation of 2 textbooks.
1. Presided Research Projects:
[1] "Relationship between the oxidation state of C106 site of DJ-1 protein and the duality of autophagy during myocardial ischemia-reperfusion and its mechanism" (National Natural Science Foundation of China, No.: 32160213, Period: Jan 2022 – Dec 2025, Presided by Chen Heping)
[2] "Investigating the new mechanism of DJ-1 mediated delayed protection of myocardial ischemic preconditioning based on the DJ-1-Grp75-mitochondrial complex I regulation pathway" (National Natural Science Foundation of China, No.: 81460060, Period: Jan 2015 – Dec 2018, Presided by Chen Heping).
[3] "Study on sasanquasaponin upregulating AE3 expression and its mechanism of regulating Cl- efflux and mitochondrial protection in ischemic/reperfused cardiomyocytes via AE3" (National Natural Science Foundation of China, No.: 81260419, Period: Jan 2013 – Dec 2016, Presided by Chen Heping).
[4] "Role of DJ-1 in delayed protection of myocardial ischemic preconditioning via the Nrf2-ARE antioxidant pathway" (National Natural Science Foundation of China, No.: 81060022, Period: Jan 2011 – Dec 2013, Presided by Chen Heping).
[5] "Anti-acute myocardial injury effect of sasanquasaponin mediated by AE3 and its mechanism" (National Natural Science Foundation of China, No.: 30660209, Period: Jan 2007 – Dec 2009, Presided by Chen Heping)
[6] "Investigating the new mechanism of resveratrol against myocardial ischemia-reperfusion oxidative stress injury based on the DJ-1/mtHsp70/mitochondrial complex I/mtROS regulation pathway" (National Natural Science Foundation of China, No.: 81960586, Period: Jan 2020 – Dec 2023, Second Participant: Chen Heping)
[7] "Molecular mechanism of resveratrol promoting DJ-1 mitochondrial sub-localization to protect complex I activity in ischemic/reperfused cardiomyocytes" (Jiangxi Provincial Natural Science Foundation Project, No.: 20192BAB205116, Period: Jun 2019 – Jun 2022, Presided by Chen Heping)
[8] "Regulatory role and mechanism of DJ-1 in the duality of autophagy during myocardial ischemia-reperfusion" (Jiangxi Provincial Natural Science Foundation Key Project, No.: 20202ACB206012, Period: Jan 2021 – Dec 2024, Presided by Chen Heping)
[9] "Role of DJ-1 in delayed protection of myocardial ischemic preconditioning and its mechanism" (Jiangxi Provincial Natural Science Foundation Project, No.: 2010GZY0220, Period: Jan 2011 – Dec 2013, Presided by Chen Heping).
[10] "Effect of RNAi silencing AE3 on myocardial ischemia-reperfusion injury" (Jiangxi Provincial Department of Education Project, No.: GJJ09085, Period: Jan 2009 – Dec 2011, Presided by Chen Heping).
[11] "14-3-3η/PKCε interaction and myocardial ischemic protection" (973 Program Preliminary Study Special Project, No.: 2009CB526405, Period: May 2009 – Aug 2011, Participant: Chen Heping).
2. Representative Publications:
[1] Liu H, Wang X, He K, Chen Z, Li X, Ren J, Zhao X, Liu S, Zhou T, Chen H#. Oxidized DJ-1 activates the p-IKK/NF-κB/Beclin1 pathway by binding PTEN to induce autophagy and exacerbate myocardial ischemia-reperfusion injury. Eur J Pharmacol. 2024 May 15;971:176496.
[2] Liu S, Xu S, Liu S, Chen H#. Importance of DJ-1 in autophagy regulation and disease. Arch Biochem Biophys. 2023 Jul 15;743:109672. doi: 10.1016/j.abb.2023.109672. Epub 2023 Jun 17. PMID: 37336341.
[3] Liu S, Ren J, Liu S, Zhao X, Liu H, Zhou T, Wang X, Liu H, Tang L, Chen H#. Resveratrol inhibits autophagy against myocardial ischemia-reperfusion injury through the DJ-1/MEKK1/JNK pathway. Eur J Pharmacol. 2023 Jul 15;951:175748. doi: 10.1016/j.ejphar.2023.175748. Epub 2023 May 5. PMID: 37149277.
[4] Zhao XY, Ren JM, Liu HR, Zhou TT, Wang XY, Liu S, Chen HP#. DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury. Biochem Biophys Res Commun. 2022 Dec 31;637:276-285.
[5] Qiu LJ, Ma ZX, Li XR, Deng YZ, Duan GL, Xu XW, Xiao, Liu HY, Zhu ZM, Chen HP#. DJ-1 is involved in the multidrug resistance of SGC7901 gastric cancer cells through PTEN/PI3K/Akt/Nrf2 pathway. Acta Biochim Biophys Sin. 2020 Dec 11;52(11):1202-1214..
[6] Zhou TT, Wang XY, Huang J, Deng YZ, Qiu LJ, Liu HY, Xu XW, Ma ZX, Tang L, Chen HP#. Mitochondrial translocation of DJ-1 is mediated by Grp75: implication in cardioprotection of resveratrol against hypoxia/reoxygenation-induced oxidative stress. J Cardiovasc Pharmacol. 2020 April; 75(4):305-313.
[7] Deng YZ, Xiao L, Zhao L, Qiu LJ, Ma ZX, Xu XW, Liu HY, Zhou TT, Wang XY, Tang L, Chen HP#. Molecular Mechanism Underlying Hypoxic Preconditioning-Promoted Mitochondrial Translocation of DJ-1 in Hypoxia/Reoxygenation H9c2 Cells. Molecules. 2020;25(1). pii: E71.
[8] Liu HY, Duan GL, Xu RY, Li XR, Xiao L, Zhao L, Ma ZX, Xu XW, Qiu LJ, Zhu ZM, Chen HP#. DJ-1 overexpression confers the multidrug resistance phenotype to SGC7901 cells by upregulating P-gp and Bcl-2. Biochem Biophys Res Commun. 2019 Oct 29;519(1):73-80.
[9] Xu RY, Xu XW, Deng YZ, Ma ZX, Li XR, Zhao L, Qiu LJ, Liu HY, Chen HP#. Resveratrol attenuates myocardial hypoxia/reoxygenation-induced cell apoptosis through DJ-1-mediated SIRT1-p53 pathway. Biochem Biophys Res Commun. 2019 Jun 25;514(2):401-406.
[10] Ding H, Xu XW, Wang H, Xiao L, Zhao L, Duan GL, Li XR, Ma ZX, Chen HP#. DJ-1 plays an obligatory role in the cardioprotection of delayed hypoxic preconditioning against hypoxia/reoxygenation-induced oxidative stress through maintaining mitochondrial complex I activity. Cell Biochem Funct. 2018 Apr;36(3):147-154..
[11] Zhang Y, Li XR, Zhao L, Duan GL, Xiao L, Chen HP#. DJ-1 preserving mitochondrial complex I activity plays a critical role in resveratrol-mediated cardioprotection against hypoxia/reoxygenation-induced oxidative stress. Biomed Pharmacother. 2018 Feb;98:545-552.
[12] Zhang Y, Li Z, Fan X, Xiong J, Zhang G, Luo X, Li K, Jie Z, Cao Y, Huang Z, Wu F, Xiao L, Duan G, Chen H#. PRL-3 promotes gastric cancer peritoneal metastasis via the PI3K/AKT signaling pathway in vitro and in vivo. Oncol Lett. 2018 Jun;15(6):9069-9074.
[13] Qiu LY, Duan GL, Yan YF, Li YY, Wang H, Xiao L, Liao ZP, Chen HP#. Sasanquasaponin induces increase of Cl‑/HCO3‑ exchange of anion exchanger 3 and promotes intracellular Cl‑ efflux in hypoxia/reoxygenation cardiomyocytes. Mol Med Rep. 2017 Sep;16(3):2953-2961.
[14] Wang H, Li YY, Qiu LY, Yan YF, Liao ZP, Chen HP#. Involvement of DJ‑1 in ischemic preconditioning‑induced delayed cardioprotection in vivo. Mol Med Rep. 2017 Feb;15(2):995-1001.
[15] Li YY, Xiao L, Qiu LY, Yan YF, Wang H, Duan GL, Liao ZP, Chen HP#. Sasanquasaponin-induced cardioprotection involves inhibition of mPTP opening via attenuating intracellular chloride accumulation. Fitoterapia. 2017 Jan;116:1-9.
[16] Zhang XG, Zhao L, Li YY, Wang H, Duan GL, Xiao L, Li XR, Chen HP#. Extracellular Cl--free–induced cardioprotection against hypoxia/ reoxygenation is associated with attenuation of mitochondrial permeability transition pore. Biomed Pharmacother. 2017 Feb;86:637-644
[17] Qiu LY, Chen HP#, Yan YF, Li YY, Wang H, Liao ZP, Huang QR. Sasanquasaponin promotes cellular chloride efflux and elicits cardioprotection via the PKCε pathway. Mol Med Rep. 2016 Apr;13(4):3597-603.
[18] Xiong J, Li Z, Zhang Y, Li D, Zhang G, Luo X, Jie Z, Liu Y, Cao Y, Le Z, Tan S, Zou W, Gong P, Qiu L, Li Y, Wang H, Chen H#. PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN. Oncol Rep. 2016 Oct;36(4):1819-28.
[19] Yan YF, Chen HP#, Huang XS, Qiu LY, Liao ZP, Huang QR. DJ-1 Mediates the Delayed Cardioprotection of Hypoxic Preconditioning Through Activation of Nrf2 and Subsequent Upregulation of Antioxidative Enzymes. J Cardiovasc Pharmacol. 2015 Aug;66(2):148-58.
[20] Li D, Li Z, Xiong J, Gong B, Zhang G, Cao C, Jie Z, Liu Y, Cao Y, Yan Y, Xiong H, Qiu L, Yang M, Chen H, Jiang S, Yang X, Chen H#. MicroRNA-212 functions as an epigenetic-silenced tumor suppressor involving in tumor metastasis and invasion of gastric cancer through down-regulating PXN expression. Am J Cancer Res 2015;5(10):2980-2997.
[21] Yan YF, Yang WJ, Xu Q, Chen HP#, Huang XS, Qiu LY, Liao ZP, Huang QR. DJ-1 upregulates anti-oxidant enzymes and attenuates hypoxia/re-oxygenation-induced oxidative stress by activation of the nuclear factor erythroid 2-like 2 signaling pathway. Mol Med Rep. 2015 Sep;12(3):4734-42.
[22] Li Z, Zhang G, Li D, Jie Z, Chen H#, Xiong J, Liu Y, Cao Y, Jiang M, Le Z, Tan S. Methylation-associated silencing of miR-495 inhibit the migration and invasion of human gastric cancer cells by directly targeting PRL-3. Biochem Biophys Res Commun. 2015 Jan 2;456(1):344-50.
[23] Zhu ZM, Li ZR, Huang Y, Yu HH, Huang XS, Yan YF, Shao JH, Chen HP#. DJ-1 is involved in the peritoneal metastasis of gastric cancer through activation of the Akt signaling pathway. Oncol Rep. 2014 Mar;31(3):1489-97.
[24] Huang XS, Chen HP #, Yu HH, Yan YF, Liao ZP, Huang QR. Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for hypoxic preconditioning-mediated delayed cardioprotection. Mol Cell Biochem. 2014 Jan;385(1-2):33-41.
[25] Yu HH, Xu Q, Chen HP#, Wang S, Huang XS, Huang QR, He M. Stable overexpression of DJ-1 protects H9c2 cells against oxidative stress under a hypoxia condition. Cell Biochem Funct. 2013 Dec;31(8):643-51.
[26] Zhong YY, Chen HP#, Tan BZ, Yu HH, Huang XS. Triptolide avoids cisplatin resistance and induces apoptosis via the reactive oxygen species/nuclear factor‑κB pathway in SKOV3PT platinum‑resistant human ovarian cancer cells. Oncol Lett 2013;6:1084-1092.
[27] Lu HS, Chen HP#, Wang S, Yu HH, Huang XS, Huang QR, He M. Hypoxic preconditioning up-regulates DJ-1 protein expression in rat heart-derived H9c2 cells through the activation of extracellular-regulated kinase 1/2 pathway. Mol Cell Biochem. 2012 Nov;370(1-2):231-40.
[28] Chen HP, He M, Mei ZJ, Huang QR, Huang M. Sasanquasaponin up-regulates anion exchanger 3 expression and elicits cardioprotection via NO/RAS/ERK1/2 pathway. Can J Physiol Pharmacol. 2012 Jul;90(7):873-80.
[29] Chen HP, He M, Mei ZJ, Huang QR, Peng W, Huang M. Anion exchanger 3 is required for sasanquasaponin to inhibit ischemia/reperfusion-induced elevation of intracellular Cl- concentration and to elicit cardioprotection. J Cell Biochem, 2011, 112 (10):2803-12.
[30] Chen HP, Liao ZP, Huang QR, He M. Sodium Ferulate attenuates anoxia/reoxygenation-induced calcium overload in neonatal rat cardiomyocytes by NO/cGMP/PKG pathway. Eur J Pharmacol. 2009, 603 (1-3):86-92.
[31] Chen HP, He M, Huang QR, Zeng GH, Liu D. Delayed protection of tetramethylpyrazine on neonatal rat cardiomyocytes subjected to anoxia-reoxygenation injury. Basic Clin Pharmacol Toxicol. 2007, 100(6):366-71.
[32] Chen HP, He M, Xu YL, Huang QR, Zeng GH, Liu D, Liao ZP. Anoxic preconditioning up-regulates 14-3-3 protein expression in neonatal rat cardiomyocytes through extracellular signal-regulated protein kinase 1/2. Life Sci. 2007, 81(5):372-9.
[33] Chen HP, He M, Huang QR, Liu D, Huang M. Sasanquasaponin protects rat cardiomyocytes against oxidative stress induced by anoxia-reoxygenation injury. Eur J Pharmacol. 2007, 575(1-3):21-7.
[34] Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M. Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway. Apoptosis, 2010, 15 (6):693-704.
[35] Liu LL, Yan L, Chen YH, Zeng GH, Zhou Y, Chen HP, Peng WJ, He M, Huang QR. A role for diallyl trisulfide in mitochondrial antioxidative stress contributes to its protective effects against vascular endothelial impairment. Eur J Pharmacol. 2014 Feb 15;725:23-31.
[36] Liao Z, Yin D, Wang W, Zeng G, Liu D, Chen HP, Huang Q, He M. Cardioprotective effect of sasanquasaponin preconditioning via bradykinin-NO pathway in isolated rat heart. Phytother Res, 2009, 23 (8):1146-53.
[37] Huang QR, He M, Chen HP, Shao LJ, Liu D, Luo YM, Dai1 YC. Protective Effects of Sasanquasaponin on Injury of Endothelial Cells Induced by Anoxia and Reoxygenation in Vitro. Basic Clin Pharmacol Toxicol. 2007, 101(5):301-8.
[38] Huang QR, Shao LJ, He M, Chen HP, Liu D, Luo YM, Dai YC. Inhibitory effects of sasanquasaponin on over-expression of ICAM-1 and on enhancement of capillary permeability induced by burns in rats. Burns 2005, 31(5):637-42.
[39] He M, Zhang J, Shao L, Huang Q, Chen J, Chen H, Chen X, Liu D, Luo Z. Upregulation of 14-3-3 isoforms in acute rat myocardial injuries induced by burn and lipopolysaccharide. Clin Exp Pharmacol Physiol. 2006, 33 (4):374-80.
[40] Nie C, Gao G, Han J, Li H, Chen HP, He M. Human papillomavirus 16 E6, E7 siRNAs inhibit proliferation and induce apoptosis of SiHa cervical cancer cells. Chinese Journal of Cancer Research, 2008, 20 (4):301-6.
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