Dong Huilei,Ph.D.

Nationality

China

Ethnicity

Han

Hometown

Shijiazhuang, Hebei

Academic Title

Special Research Fellow

Administrative Post

None

Teacher Type

Doctoral Supervisor

Email

huileidong@ncu.edu.cn

Research Interests

1. Design and Development of Peptide-based Targeted Drugs: Utilizing disulfide-directed cyclization to create cell-penetrating and targeted bifunctional ultra-stable bicyclic peptides, which serve as targeting ligands for Peptide-Drug Conjugates (PDCs). Targeting sequences are identified against highly expressed cancer-specific cell surface proteins using mRNA display/phage display technologies, aiming to develop specific PDC drugs for various malignancies.

2. Functional Peptide Assemblies for Biomedical Applications: Engineering smart, redox-responsive self-assembling peptide biomaterials using disulfide bonds as molecular switches. Exploring their applications in biomedicine, including cell therapy and efficient nucleic acid drug delivery.

3. Development and Application of Functional Peptides (e.g., Antimicrobial, Anti-inflammatory): Screening bioactive peptides from natural sources and employing computer-aided drug design (CADD) and artificial intelligence (AI) to optimize their structures for improved drug-like properties.

Education

2017.09~2021.06：2017.09-2021.06 Ph.D. Xiamen University

2014.09~2017. 06：M.S. Nanjing Normal University

Work Experience

2024.09-Present Special Research Fellow / Independent PI. Institute of Biomedical Innovation, Nanchang University

2022.01-2024.06 Postdoctoral Researcher. Wenzhou Research Institute of Chinese Academy of Science

Teaching Information

1. Spectral analysis；2. Chemometrics

Professional Affiliations

1. Standing Committee Member, Drug Chemistry Committee (2nd Term), Jiangxi Pharmaceutical Association.；

2. Council Member (2nd Term), Jiangxi Society for Cell Biology

Research Achievements

Research Projects:

1. National Natural Science Foundation of China (NSFC) Young Scientist Fund (Category C). Period: Jan 2024 – Dec 2026. Funding: ¥300,000. (Ongoing)

2. China Postdoctoral Science Foundation. Period: Jul 2022 – Jun 2024. Funding: ¥80,000. (Completed)

3. Jiangxi Provincial "Ganpo Talents" Program — Leading Talent for Innovation: Period: Jan 2026 – Dec 2028. Funding: ¥1,000,000. (Ongoing)

4. High-Level Talent Startup Grant, Nanchang University (PI): Period: Sep 2024 – Sep 2030.

2、Publications

[1] Huilei Dong, Jinjing Li, Hongtan Liu, Shuaimin Lu, Junjie Wu, Youming Zhang, Yizhen Yin*, Yibing Zhao, Chuanliu Wu*. Design and Ribosomal Incorporation of Noncanonical Disulfide-Directing Motifs for the Development of Multicyclic Peptide Libraries. Journal of the American Chemical Society, 2022, 114: 5116-5125. (JCR1，IF=15.4)

[2] Huilei Dong, Mingshui Wang, Shihui Fan, Chuanliu Wu, Chunhui Zhang, Xia Wu, Bin Xue, Yi Cao,Junjie Deng, Dan Yuan*, Junfeng Shi*. Redox-Regulated Conformational Change of Disulfide-Rich Assembling Peptides. Angewandte Chemie International Edition, 2022, 61: e2022128. (JCR1，IF=16.8)

[3] Yuting Cai, Yatong Xiang, Huilei Dong*, Wenjing Huang, Yan Liu, Chenguang Zhao, Dan Yuan, Yun Li*, Junfeng Shi*. Injectable Self-assembling Peptide Hydrogel as a Promising Vitreous Substitute. Journal of Controlled Release, 2024, 376: 402-412. (JCR1，IF=11.5)

[4] Wenjing Huang^#, Huilei Dong^#, Qipeng Yan, Tingfen Deng, Zenghui Li, Mingshui Wang, Chunhui Zhang*, Junfeng Shi1*, Dan Yuan*. Disulfide-Rich Self-assembling Peptides Based on Aromatic Amino Acid. Small, 2025, 21, 2407464. (JCR1，IF=13)

[5] Huilei Dong, Xiaoting Meng, Xiaoli Zheng, Xueting Cheng, Yiwu Zheng, Yibing Zhao, Chuanliu Wu*. Design and Synthesis of Cross-Link-Dense Peptides by Manipulating Regioselective Bisthioether Cross-Linking and Orthogonal Disulfide Pairing. The Journal of Organic Chemistry, 2019, 84: 5187-5194. (JCR1, IF=4.7)

[6] Huilei Dong, Hongfei Chen, Juqian Jiang, Hui Zhang, Chenxin Cai, Qingming Shen, Highly Sensitive Electrochemical Detection of Tumor Exosomes Based on Aptamer Recognition-Induced Multi-DNA Release and Cyclic Enzymatic Amplification. Analytical Chemistry, 2018, 90(7): 4507-4513. (JCR1，IF=6.8)

备注

Research Group Website：https://www.x-mol.com/groups/HuileiDong

课题组主页