Dr Lai, Junshan

Dr Lai, Junshan

Study and Research Experiences

Research interests

Focusing on research in the following areas and exploring their applications in drug synthesis:

1. Asymmetric catalysis: Research on asymmetric catalytic reactions involving chiral catalysts.

2. Catalysts immobilization and continuous flow chemistry: Design and immobilization of small-molecule chiral catalysts, as well as their applications in continuous flow chemistry.

3. Artificial Intelligence (AI) asymmetric catalysis: Discovery and design of asymmetric catalytic reactions assisted and guided by AI, as well as catalyst design.

4. Organic electrochemistry and development of organic synthesis methodology.

Publications

1. Junshan Lai, Benjamin List*, Jolene Reid*. Bis-indole chiral architectures for asymmetric catalysis. Nat. Commun. 2025, 16, 3676. （IF=14.7/Q1）

2. Isaiah O. Betinol§; Junshan Lai§; Saumya Thakur; Jolene Reid*. A Data-Driven Workflow for Assessing and Predicting Generality in Asymmetric Catalysis. J. Am. Chem. Soc. 2023, 145, 12870–12883. （co-first author, IF=16.38/Q1）

3. Junshan Lai, Jolene Reid*. Interrogating the thionium hydrogen bond as a noncovalent stereocontrolling interaction in chiral phosphate catalysis. Chem. Sci. 2022, 13, 11065-11073. （IF=9.97/Q1）

4. Junshan Lai; Jolene P. Reid*. A Bulky Imidodiphosphorimidate Brønsted Acid Enables Highly Enantioselective Prins-semipinacol Rearrangements. ACS Catal. 2024, 14,8518-8527.（IF=13.70/Q1）

5. Junshan Lai, Mauro Fianchini, Miquel A. Pericàs*. Development of Immobilized SPINOL-Derived Chiral Phosphoric Acids for Catalytic Continuous Flow Processes. Use in the Catalytic Desymmetrization of 3,3-Disubstituted Oxetanes. ACS Catal. 2020, 10, 14971-14983. （IF=13.70/Q1）

6. Junshan Lai, Miquel A. Pericàs*. Manganese/Copper Co-catalyzed Electrochemical Wacker–Tsuji-Type Oxidation of Aryl-Substituted Alkenes. Org. Lett. 2020, 22, 7338-7342. （IF=6.07/Q1）

7. Junshan Lai, Rifahath M. Neyyappadath, Andrew D. Smith, Miquel A. Pericàs. Continuous flow preparation of enantiomerically pure binol(s) by acylative kinetic resolution. Adv. Synth. Catal. 2020, 362, 1370-1377. （IF=5.8/Q1）

8. Junshan Lai, Sonia Sayalero, Alessandro Ferrali, Laura Osorio-Planes, Fernando Bravo, Carles Rodríguez-Escrich, Miquel A. Pericàs. Immobilization of cis-4-hydroxydiphenylprolinol silyl ethers onto polystyrene. Application in the catalytic enantioselective synthesis of 5-hydroxyisoxazolidines in batch and flow. Adv. Synth. Catal. 2018, 360, 2914-2924. （IF=5.8/Q1）

9. Junshan Lai, Yongping Liang, Teng Liu, Shouchu Tang. Dithiane induced cycloaddition/ aromatization tactic for the synthesis of multisubstituted furans. Org. Lett. 2016, 18, 2066-2069. （IF=6.07/Q1）

10. Junshan Lai, Lixia Tian, Yongping Liang, Yuan Zhang, Xingang Xie, Bowen Fang, Shouchu Tang. Di-tertbutyl peroxide mediated atom transfer radical addition of 2-chlorodithiane to aryl alkynes under mild conditions. Chem. Eur. J. 2015, 21, 14328–14331. （IF=5.02/Q2）

11. Junshan Lai, Lixia Tian, Xing Huo, Yuan Zhang, Xingang Xie, Shouchu Tang. Metal-free difunctionalization of alkynes with 2-chlorodithiane for synthesis of β-ketodithianes. J. Org. Chem. 2015, 80, 5894–5899.（IF=4.02/Q2）

12. Junshan Lai, Wenbin Du, Lixia Tian, Changgui Zhao, Xuegong She, Shouchu Tang. Fe-catalyzed direct dithioacetalization of aldehydes with 2-chloro-1, 3-dithiane. Org. Lett. 2014, 16, 4396–4399.（IF=6.07/Q1）

Honor & Awards

2021-2025 UBC Postdoctoral Research Fellow

2020 URV CUM LAUDE

2017-2020 Ministerio FPI grant

2016-2017 ICIQ PhD Fellowship Programme

2015 National Scholarship for Postgraduate students

2014 National Scholarship for Postgraduate students

2014 Miyoshi Graduate of Lanzhou University

2013 The First Prize Scholarship of Lanzhou University