Xiluan Yan, Ph.D.
Affiliation: School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330031, PRC
Tel: (86)15970427701
E-mail: yanxiluan@ncu.edu.cn
Date of Birth: 05/05/1975
Education
Sept.1995-Jul. 1999 B.S. in pharmacy
Jiangxi University of Traditional Chinese Medicine (TCM), China
Sept.1998-Jun.2001 B.A.in English
Jiangxi Normal University, China
Sept.2001-Jul.2004 M.S.in pharmaceutics of Chinese herbology
Jiangxi University of Traditional Chinese Medicine, China
Thesis Topic: Research and Preparation of ZhongJieFeng Sprayer
Sept.2006-Jun.2009 Ph.D. in pharmaceutical analysis
Fudan University, China
Thesis Topic: Aptamer-based Chemiluminescence Assay
Work Experience
Jul.1994-Jul.2001 Laboratory technician, Department of Natural Products Chemistry, Jiangxi University of Traditional Chinese Medicine
Jul.2004-Dec.2013 Lecture, Department of Chemical Engineering, Nanchang University
Jun.2014-Dec.2022 Associate professor, Department of Chemical Engineering, Nanchang University
Jun.2023-present Professor,School of Pharmacy, Jiangxi Medical College, Nanchang University
Research Interests
1. Micro / nano scale biosensor or materials were prepared, and chemiluminescence, fluorescence, colorimetry and other multiple signal amplification techniques were used to explore their accurate detection in medicine, environment and food.
2. With modern analytical methods, droplet digital immunoassay was used to achieve ultra-high sensitivity detection of trace bioactive molecules, covering scientific research, industrial and clinical early diagnosis, and breaking through the bottle neck of low abundance protein detection.
3. Quality control technology of traditional Chinese medicine preparation and chemical products from traditional Chinese medicine.
Research Projects
2025.01-2027.12 Principal investigator, Research Project “Research and Development of a New Nanomaterial biosensor for the Analysis of exogenous harmful residues in traditional Chinese Medicine”, Supported by the Science Fund for Discipline Leaders of Ganpo Juncai Distinguished Scholars of Jiangxi Province in 2024 (No.20243BCE51006).
2024.01-2027.12 Principal investigator, Research Project “Development of novel biosensors with NiNPs as catalyst and its application in the detection of traditional Chinese medicine residues”, Supported by National Nature Science Foundation of China (No. 82360857).
2021.10-2024.10 Principal investigator, Research Project “Study of novel chemiluminescen aptasensor combined with exonuclease technique and its application in early screening of malignant tumor”, Supported by Supported by Natural Science Foundation of Jiangxi Province, (No. 20212BAB206093).
2017.01-2020.12 Principal investigator, Research Project “Lable-free aptamer-based Chemiluminescent Detection of OTA and ATP from Food Contaminants Coupled to Magnetic Beads as Carrier”, Supported by National Nature Science Foundation of China (No.31660491).
2012.01-2014.12 Principal investigator, Research Project “Development of Immunological Analytical Technology on Chemiluminescent Amplification Detection with Signal- encapsulated Liposome”, Supported by National Nature Science Foundation of China (No.81102289).
2013.01-2015.12 Principal investigator, Research Project “Development of Tumor Cell Chemiluminescent Detection with Luminol-encapsulated Liposome”, Supported by Natural Science Foundation of Jiangxi Province, (No. 20132BAB205106).
2010.01-2012.12 Principal investigator, Research Project “preparation of Immunoliposome and Its Application as amplification carrior”, Supported by Science Foundation of Jiangxi Educational Committee (No.GJJ10053).
2015.01-2018.12 Co-Investigator, Research Project “The effects of exogenous PGE2 on bone remodeling of late growth beagle with mandibular protraction model ”, Supported by National Nature Science Foundation of China (No. 81460100).
2012.01-2014.12 Co-Investigator, Research Project “Research on pharmacological effects of camphor tree seed kernel oil and development of medicinal and functional edible oil products” Supported by program of International S&T Cooperation Projects of China (No.2011DFA32770).
Publications
1． Xiluan Yan, Hongyi Mu, Yun He, etc. Self-synergy-powered Ni/Fe nanocube-based cholesterol detection with dual modes[J] Talanta 2025,291:127860.
2． Wentai Feng, Minjing Zhang, Jianhong Yan, Jiaying Tang, Jianing Zeng, Fanrong Ai , Xiangjuan Zheng*, Xiluan Yan*，Fluorescence-colorimetric dual detection method for quantitative detection of uric acid in urine based on the competitive oxidation between cerium (IV) and o-phenylenediamine induced by target substances [J] Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2025,338:126168.
3． Xiangjuan Zheng, Bangyang Hu, Kexin Yuan, Ting Wu, Xiluan Yan*, Designing CuO@rGO-MoS2 Nanocomposite with Bird’s-Nest Like Structure as Peroxymonosulfate Activator for the Efficient Degradation of Rhodamine B[J] Langmuir, 2025, 41, 9769−9783.
4． Xiluan Yan, Wei Wang, Pengyan Jiang, Aiping Fan, Zhijuan Cao , Xiangjuan Zheng, Fanrong Ai , Liang Guo* HOF@Co/Heme as an enzyme-mimic probe for luminol chemiluminescence detection of glucose[J]Microchemical Journal 2025,215: 114403.
5． Yun He, Yipi Xiao, Xixi Ma, Kangyi Guo, Liang Guo, Aiping Fan, Xiangjuan Zheng, Fanrong Ai, Xiluan Yan*. Sensitive chemiluminescence detection platform for H2O2 and glucose through facile inorganic salt etching of cobalt Prussian blue analogues[J]Microchimica Acta 2025,192:411.
6． Kangyi Guo, Yipi Xiao, Yun He, Jie Liu, Liang Guo, Aiping Fan, Zheling Zeng, Xiangjuan Zheng, Xiluan Yan. Ultra convenient and rapid synthesis of FeAg MOGs for sensitive test strips detection of dopamine in human serum[J]Microchimica Acta 2025,192:702.
7． Xiluan Yan, Jiani Wang, Lei Yang, Pengyan Jiang, Yun He, Wei Wang, Aiping Fan, Zhijuan Cao, Xiangjuan Zheng, Fanrong Ai, and Liang Guo*Hierarchical CoZn-MOF-Supported Ag Nanocatalyst for Chemiluminescence Assay[J] ACS Appl. Nano Mater. 2025, 8, 21551−21561.
8． Xiangjuan Zheng, Zhiying Shi, Chun Han,Hongyi Mu,Shiyun Cheng,Xiluan Yan*, Convenient in situ self-assembled formation of dual-functional Ag/MXene nanozymes for efficient chemiluminescence sensing[J] Anal. Methods, 2024, 16, 8324–8332.
9． Xiluan Yan, Shiyun Cheng, Yipi Xiao, Shuangbin Wu, Hongyi Mu, Zhiying Shi , Liang Guo, Fanrong Ai, Xiangjuan Zheng, Based on Fe and Ni prepared organic colloidal materials as efficient oxide nanozymes for chemiluminescence detection of GSH and Hg(II) ions[J] Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2024, 321: 124696
10． Zhiying Shi, Ting Wu, Wentai Feng, Bangyang Hu, Xiluan Yan* , Xiangjuan Zheng*, Enhanced luminol chemiluminescence with oxidase-like properties of prussian blue/MXene nanocomposite without H2O2 for the sensitive detection of uric acid[J] Microchemical Journal, 2024,206:111455
11． Xiangjuan Zheng, Zhiying Shi, Chaojun Fu, Yuanlin Ji, Baozhu Chi, Fanrong Ai, Xiluan Yan*, A novel fuorescent nanoprobe based on potassium permanganate–functionalized Ti3C2 QDs for the unique “turn on” dual detection of Cr3+ and Hg2+ ions [J]. Microchimica Acta 2023,190:153.
12． Zhiying Shi , Bangyang Hu, Shengya Ge , Baozhu Chi, Xiluan Yan* , Xiangjuan Zheng * Facile preparation of bimetallic Au-Cu nanoclusters as fluorescent nanoprobes for sensitive detection of Cr3+ and S2O8 2- ions [J].Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2023,301:122855
13． Qinglei Shu , Yafei Zhu , Yipi Xiao , Kaisen Chen , Xi Mai , Xiangjuan Zheng , Xiluan Yan* , A novel chemiluminescence biosensor based on dual aptamers bound nanoparticles with multi-site signal amplification for sensitive detection of carcinoembryonic antigen [J].Microchemical Journal 2022,179:107482.
14． Xiluan Yan, Kun Zhao, Yunting Yang, Aojun Qiu, Xinlei Zhang, Jie Liu, Chengyi Zha, Xi Mai,Fanrong Ai ,Xiangjuan Zheng. Utilizing dual carriers assisted by enzyme digestion chemiluminescence signal enhancement strategy simultaneously detect tumor markers CEA and AFP[J] Analytical Sciences 2022,38:889–897.
15． Yan Xiluan, Zhao Kun , Yang Yunting, Xiao Yipi , Zha Chengyi , Mai Xi , Liu Jie Chemiluminescent detection of platelet derived growth factor-BB based on sandwich label-free aptasensor and biotin–streptavidin strategy[J] Journal of Immunological Methods 2022,506:113289.
16． Chaojun Fu, Fanrong Ai, Jianzhen Huang, Zhiying Shi, Xiluan Yan*, Xiangjuan Zheng* .Eu doped Ti3C2 quantum dots to form a ratiometric flfluorescence platform for visual and quantitative point-of-care testing of tetracycline derivatives [J] Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022，272 ：120956.
17． Fanrong Ai, Chaojun Fu, Guojun Cheng, Huanhuan Zhang, Yingchun Feng, Xiluan Yan,* ,Xiangjuan Zheng* Amino-Functionalized Ti3C2 MXene Quantum Dots as Photoluminescent Sensors for Diagnosing Histidine in Human Serum [J]ACS Appl. Nano Mater. 2021, 4, 8192−8199.
18． Xiluan Yan, Qinglei Shu, Kun Zhao, Yipi Xiao,Fanrong Ai, Xiangjuan Zheng. Chemiluminescence "signal-on-off" dual signals ratio biosensor based on single-stranded DNA functions as guy wires to detect EcoR V.[J] Talanta, 2021 ,235,122749.
19． Xiluan Yan,Yuanlin Ji, Yibi Xiao, Xinxin Xue, Jie Liu, Su Li, Fangrong Ai, Xiangjuan Zheng. One-pot label-free dual-aptasensor as a chemiluminescent tool kit simultaneously detect ATP and CAP in foods[J] Talanta, 2021 ,229,122226.
20． Xiluan Yan, Xinxin Xue,Jing Luo,Yuting Jian, Li Tong, Xiangjuan Zheng. Construction of chemiluminescence aptasensor platform using magnetic microsphere for ochratoxin A detection based on G bases derivative reaction and Au NPs catalyzing luminol system[J]Sensors & Actuators:B.Chemical 2020,320,128375.
21． Xiluan Yan, Mengmeng Jiang,Ying Hu, Le Wu, Kun Zhao, Xinxin Xue, Xiangjuan Zheng. A new chemiluminescence method for the determination of 8-hydroxyguanine based on L-histidine bound nickel nanoparticles[J] Chemical Communications, 2020, 56: 6535 - 6538.
22． Xiluan Yan, Xinxin Xue, Xuemei Deng,Yuting Jian,Jing Luo,Mengmeng Jiang,Xiangjuan Zheng. Chemiluminescence strategy induced by HRP-sandwich structure based on strand displacement for sensitive detection of DNA methyltransferase[J] Microchemical journal 2020,158,105183.
23． Xiluan Yan, Mengmeng Jiang,Yuting Jian,Jing Luo, Xinxin Xue, Xin Chen,Xiangjuan Zheng, Fangrong Ai. Simultaneous aptasensor assay of ochratoxin A and adenosine triphosphate in beer based on Fe3O4 and SiO2 nanoparticle as carriers [J] Analytical methods,2020,12(17):2253-2259.
24． Xiluan Yan, Zhijuan Cao, Choiwan, et al. DNA Aptamer folding on magnetic beads for simultaneous detection of adenosine and cocaine by substrate-resolved chemiluminescence technology[J]Analyte,2010,135:2400-2407.
25． Xiluan Yan, Zhijuan Cao, Masaaki Kai, et al. Label-free aptamer-based chemiluminescence detection of adenosine[J]Talanta, 2009,79:383-387.
26． Xiluan Yan, Xin Chen, Wenju Gao,et al. Nanoparticles Grafted by Aptamer:Preparation and Application in Chemiluminescence Enzyme Analysis[J] Chinese Journal of Inorganic Chemistry, 2017，33（2）：340-346.
27． Xiluan Yan，Xin Chen, Jie Liu, et al. Detection of Adenosine Based on Aptamer Biosensor with Alkaline Phosphatase Chemiluminescence Assay[J]Journal of Instrumental Analysis, 2017，36（4）：565-569.
28． Lu Lu, Xiluan Yan*,Yibei Xiao, et al. Aptamer-based Chemiluminescenct Detection of Adenosine[J]Journal of Instrumental Analysis,2014,33(1):73-77.
29． Xiluan Yan，Li Tong，Yibei Xiao, et al.Detection of Cocaine Based on Magnetic Microspheres with Chemiluminescence Assay[J]Journal of Instrumental Analysis,2013,32(12):1472-1476.
30． Xiluan Yan, Yibei Xiao, Lu Lu, et al.Study on Detection of CEA Based on Magnetic Beads with Luminal-encapsulated Liposome Chemiluminescence Assay.[J] Journal of Nanchang University (natural science),2013,37(5):464-468.
31． Xiluan Yan，Song Xiao，Zheling Zeng，Detection of Human IgG with Biosensor Based on SRB-Encapsulated Liposomes[J] Food Chemistry(China), 2009,34(18):141-145.
32． Xiluan Yan, Hongjun Chen. The Effect of Matrix on Establishment of Microcapsule[J] Journal of Nanchang University (natural sicence),2007,31(1):97-99.
33． Xiluan Yan, Yibei Xiao, Bao Zhang. The preparation of compound zhongjiefeng spray and its quality standard[J] Journal of Jiangxi University of TCM, 2006,18(1)：30-30.
34． Xiluan Yan, Jianghang Zhu, Bao Zhang. HPLC method for the determination of indigo content in compound zhongjiefeng spray [J] Journal of Jiangxi University of TCM, 2005.17(6):32-34.
35． Yan Li, Xiluan Yan, Jieping Fan,et al. Feasibility of biogas production from anaerobic co-digestion of herbal-extraction residues with swine manure[J] Bioresource Technology 2011 (102) 6458–6463.
36． Jianhang Zhu, Xiluan Yan, Hongjun Chen,et al.In-situ extraction of intracellular protein using thermoseparating aqueous two-phase system[J]Journal of Chromatography A, 2007,(1147):127-134.
37． Jianhang Zhu, Xiluan Yan, Ye Liu, et al. Improving alachlor biodegradability by ferrate oxidation[J] Journal of Hazardous Materials, 2006，(135) 94-99.
38． Jianghang Zhu, Bao Zhang, Xiluan Yan, et al. Preparation and characterization of chito san/ terpolymer microcap sule[J] Journal of Chemical Indust ry and Engineering (China),2006,57(1):85-90.
39． Jianghang Zhu, Bao Zhang, Xiluan Yan, et al. Encapsulating Hepatocytes with Chitosan in Physiological Conditions[J]Journal of biomedical Engineering,2006,23(5):1070-1074.
40． Hongbing Wu, Jianxu Li, Qizhi Zhang, Xiluan Yan,et al. A novel small Odorranalectin-bearing cubosomes: Preparation, brain delivery and pharmacodynamic study on amyloid-b25–35-treated rats following intranasal administration[J] European Journal of Pharmaceutics and Biopharmaceutics, 2012, (80): 368–378.
Filed Chinese Patent Applications
1. Xiluan Yan，et al. A Determined Method of OTA Based on DNA Aptamer Folding and Hydroxylamine Amplified Au Nanoparticles by Chemiluminescence Technology, ZL201610814199.0
2. Xiluan Yan, et al. OTA Chemiluminescence Detection Technology Based on Aptamer Labeled HRP Enzyme, ZL201610814093.0
3. Xiluan Yan, et al. OTA Chemiluminescence Detection Technology Based on Lable-free Aptamer, ZL201610814401.4.
4. Xiluan Yan, et al. An ATP Chemiluminescence Detection Method Based on Enzyme-Cleavage-Assisted Unlabeled Aptamer BioSensor. ZL202010834990.4
5. Xiluan Yan, et al. A Preparation Method of A Nickel Ferrocyanide Nanoparticle Chemiluminescent Aptasensor for Detecting 8-OHdG. ZL 202010205370.4
6. Xiluan Yan, et al. A Rapid Chemiluminescent Detection Method for Multiple Tumor Markers based on Self-assembled DNA Nucleic Acid Chain Sensors.ZL 202211453743.5
7. Xiluan Yan, et al. A Chemiluminescent Detection Method for Glucose based on Metal-doped Hydrogen Bond Organic Frame Materials.ZL 202510629202.0
8. Xiluan Yan, et al. A Method for the Preparation of A Bimetallic MOF Loaded Enzyme Simulator and Its Application .Application No.202510629199.2
Teaching achievements
2014.01-2020.06 Principal investigator, Teaching reform Project “A Preliminary Study on Characteristic Teaching Methods for Talent Cultivation in Pharmaceutical Engineering”, Supported by High-educational Foundation of Jiangxi Educational Committee (No.JXJG-14-1-24).
Teaching reform paper
1. Xiluan Yan，Jie Liu，Yihao Jiang.A Preliminary Study on the Talent Cultivation Model of Pharmaceutical Engineering Majors in Teaching-Oriented Universities under the Concept of Engineering Education Accreditation[J]Education Teaching Forum ，2019,50:31-32.
2. Xiluan Yan，Jie Liu，Yan Zeng，Hui Yang，Xiaowu Bai. Practice and exploration of mental health soft power for science and engineering students [J]Educator，2020，33：28-29.
Professional books compilation
1.Subeditor：“Pharmaceutical Analysis” (ISBN:978-7-5677-3323-7) Beijing: Jilin University Press，2015.
2.Subeditor：“Molecular mechanism and toxicology of anti-tumor drugs” (ISBN:978-7-5610-9598-0) Liaoning: Liaoning University Press，2020.
3.Editor：“Industrial Pharmacy” (ISBN:978-7-89505-172-0) Beijing: Science and Technology Press，2024.
Additional teaching achievements
2019： The excellent course "Pharmacy" at Nanchang University
2020： Jiangxi Province's first-class undergraduate course "Pharmacy"
2022： First Prize winner of Nanchang University Teaching Achievement Award, ranked 1st
2023： Jiangxi Provincial Model Project for Ideological and Political Education in Curriculum
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