Huang Qiren,Professor

Citizenship

China

Nationality

Han

Place of Birth

Ganzhou Jiangxi

Job Title

Professor

Position

Director of Academic Committee, Pharmacy School

Tutor Type

Doctoral Supervisor

E-mail

qrhuang@ncu.edu.cn

Teaching Course

Pharmacology，Introduction to Pharmacy

Research Interests

Mechanism and drug molecular targets of diabetic cardiovascular and cerebrovascular diseases

Energy metabolism homeostasis disorder and obesity

Education

1988.9-1993.7: M.B., Public Health /Preventive Medicine, Jiangxi Medical College

1996.9-1999.7: M.Sc., Cardiovascular Pharmacology, Jiangxi Medical College

2001.9-2004.7: Ph.D., Burn Surgery, Jiangxi Medical College

Employments

1993.7-to date: Assistant Professor, Lecturer, Associate Professor and Professor, Nanchang University, China

2005.8-2005.12: Visitor, State Key Laboratory of Bio-membrane and Membrane Biology, Tsinghua University，China

2006.4-2007.5: Post-doctoral, Boston University，USA

Memberships

² Member of the Pharmacological Committee of Metabolic Diseases, the Chinese Pharmacological Society

² Standing Committee Member of the Teaching and Popular Science Professional Committee, the Chinese Pharmacological Society

² Standing Committee Member of the Network Pharmacology Professional Committee, the Chinese Pharmacological Society

² Member of the Anti-Cancer Drugs Professional Committee, the China Anti-Cancer Association

² Member of the Tumor Pharmacology and Chemotherapy Professional Committee, the Chinese Pharmacological Society

² Vice Chairman of Jiangxi Pharmacological Society

² Peer reviewer for the European Research Council (ERC) program of the European Commission

² Peer reviewer for National Science and Technology Awards of China

² Peer reviewer for the National Natural Science Foundation of China

² Evaluation expert for the degree and postgraduate education by the Ministry of Education of China

Academic Title

² The candidate of academic and technical leaders in major disciplines in Jiangxi Province (2012)

² The title of "Middle-aged and Young Academic Leader of Jiangxi Province's Colleges and Universities" (2010)

² The candidate for Jiangxi Province's New Century "Hundred, Thousand, Ten Thousand Talents Project" (2008)

² The candidate for the "Three Hundred Talents Project" " of Nanchang University (2021)

Grants, Publications,

Awards

1. Grants

(1) Asprosin involves the pathogenesis of obesity through regulating the beigeing of white adipose mediated by mitophagy via TLR4-ULK1 axis. Natural Science Foundation of China, No.82460729, 2025.1-2028.12,￥320,000.

(2) PPARγ1 and FOXO1 which are important nuclear transcriptional factors cooperatively regulate systemic insulin sensitivity, Natural Science Foundation of China,No.81960153, 2020.1-2023.12,￥340,000.

(3) Osteopontin promotes committed differentiation of white adipocytes to brown adipocytes via a CD44-PI3K-AKT-PPARγ dependent pathway, Natural Science Foundation of China, No.31660323, 2017.1-2020.12,￥380,000.

(4) Role of sumoylational modification of PPARγ1 in endothelial insulin resistance induced by high glucose or hyperglycemia, Natural Science Foundation of China, No.81360060, 2014.1-2017.12,￥490,000.

(5) The role and mechanism of PPARγ transcriptional inhibition of the NF-κB pathway in resisting high glucose-induced insulin resistance in vascular endothelium, Natural Science Foundation of China, No.81070633, 2011.1-2013.12, ￥310,000.

(6) IKKα/β regulates the NF-κ B-independent pathway of insulin resistance and dysfunction in vascular endothelium induced by high glucose, Natural Science Foundation of China, No. 30860111, 2009.1-2011.12,￥230,000.

(7) Study on the mechanism of vascular endothelial injury induced by high glucose mediated by anion exchanger 2 (AE2), Natural Science Foundation of China, No.30660058, 2007.1-2009.12,￥210,000.

(8) The interaction betwween14-3-3η and PKCε and its protective effect on myocardial ischemia, the Preliminary Research Special Project of the 973 Program, the Ministry of Science and Technology, No. 2009CB526405, 2009.1-2011.12,￥650,000.

(9) Study on astringe substance of Baihuajimu, National Science and Technology Support Project of the Ministry of Science and Technology, No.2009BADC3B04, 2009.1-2012.12.￥1,740,000.

(10) Role and mechanism of Asprosin in ferroptosis of brown adipocytes based on the Asprosin-specific deficient model of adipose tissue, Natural Science Foundation of Jiangxi Province, No.20232ACB206061, 2024.1-2026.12,￥200,000.

(11) Role and mechanism of the interaction between PPARγ and NF-κB in insulin resistance of vascular endothelial cells induced by high glucose, the Grant of Academic and Technical Leaders in Major Disciplines in Jiangxi Province, No.20123BCB22005, 2012.1-2014.12,￥200,000.

2. Publications

（1） Huang QQ, Xiong X, Chen S,Wang Y, Wang L, Liu W, Liu C, Zeng G*, Huang Q^*. Asprosin aggravates tubular epithelial cell injury and phenotypic transformation via mitochondrial dynamics disorder mediated by excessive Drp1 SUMOylation in diabetic nephropathy mice. Adv. Sci. 2025; 12, e03259. doi: 10.1002/advs.202503259. (CAS, Q1, TOP，IF:14.1)

（2） Liu W, Wang Y, Liu C, Shi B, Xiong X, Chen S, Huang QQ,Wang L, Zeng G, Huang Q*. Pro-atherosclerotic effects of osteopontin is contributed to promoting foam cell formation derived from VSMCs by inhibiting cholesterol efflux. The FASEB J. 2025; 39(9). doi: 10.1096/fj.202403104RR. (CAS, Q2，IF:4.4 )

（3） Zeng W, Wang L, Wang C, Xiong X, Huang QQ, Chen S, Liu C, Liu W, Wang Y, Huang Q*. SENP1 prevents high fat diet-induced non-alcoholic fatty liver diseases by regulating mitochondrial dynamics. BBA-Mol Basis Dis. 2025;1871 (1). doi: 10.1016/j.bbadis. 2024.167527. (CAS, Q2，IF:4.2)

（4） Wang Y, Liu W, Liu C, Zhou Z, Chen S , Huang QQ,Wang L, Zeng G, Huang Q*. Asprosin attenuates diabetic cardiomyopathy through inhibiting autophagy mediated by AMPK/mTOR/ULK1 pathway.Am J Physiol-Cell Physiol.2025;329(1). doi: 10.1152/ ajpcell.01006.2024. (CAS, Q3，IF:5.5 )

（5） Chen S, Yuan W, Huang QQ, Xiong X,Wang C, Zeng W, Wang Li, Huang Y, Liu Y, Wang Y, Huang Q*. Asprosin contributes to pathogenesis of obesity by adipocyte mitophagy induction to inhibit white adipose browning in mice. Int J Obesity. 2024; 2. doi: 10.1038/s41366-024-01495-6.(Nature index Journal，CAS, Q2，IF:4.2)

（6） Wang L, Zeng W, Wang C, Lu Y, Xiong X, Chen S, Huang QQ, Yan F, Huang Q*. SUMOylation and coupling of eNOS mediated by PIAS1 contributes to maintenance of vascular homeostasis. The FASEB J. 2024;38(1):e23362. doi: 10.1096/fj.202301963R.(CAS, Q2, TOP，IF:4.8)

（7） Wang C, ZengW, Wang L, Xiong X, Chen S, Huang QQ, Zeng G, Huang Q*. Asprosin aggravates nonalcoholic fatty liver disease via inflammation and lipid metabolic disturbance mediated by reactive oxygen species. Drug Dev Res. 2024;85:e22213. doi:10.1002/ ddr.22213.（CAS, Q3, IF:3.8）

（8） Lu Y, Yuan W, Xiong X, Huang QQ, Chen S, Yin T, Zhang Y, Wang Z, Zeng G, Huang Q*. Asprosin aggravates vascular endothelial dysfunction via disturbing mitochondrial dynamics in obesity models. Obesity (Silver Spring). 2023;31:732-743. doi: 10.1002/oby.23656. (CAS, Q2，IF:9.298)

（9） Xiong S, Yu S, Wang K, Xiong X, Xia M, Zeng G, Huang Q*. Dietary apigenin relieves body weight and glycolipid metabolic disturbance via pro-browning of white adipose mediated by autophagy inhibition. Mol Nutr Food Res. 2023; 2200763. doi:10.1002/mnfr.202200763. (CAS, Q2，IF:6.575)

（10） Huang Q, Chen S, Xiong X, Yin T, Zhang Y, Zeng G, Huang QR*. Asprosin exacerbates endothelium inflammation induced by hyperlipidemia through activating IKKβ-NF-κBp65 pathway. Inflammation. 2023;46(2):623-638. doi: 10.1007/ s10753-022- 01761-7. (CAS, Q2，IF:4.657)

（11） Zhang Y, Huang Q, Xiong X, Yin T, Chen S, Yuan W, Zeng G, Huang Q*. Acacetin alleviates energy metabolism disorder through promoting white fat browning mediated by AC-cAMP pathway. J Physiol Biochem. 2023; 79(3): 529-541. doi: 10.1007/s13105-023-00947-3. (CAS, Q3，IF:3.4)

（12） Kong Y, Niu A, Yuan W, Zhou Y, Xia M , Xiong X, Lu Y, Yin T, Zhang Y, Chen S, Huang QQ, Zeng G, Huang Q*.Interaction of FOXO1 and SUMOylated PPARγ1 induced by hyperlipidemia and hyperglycemia favors vascular endothelial insulin resistance and dysfunction.Vasc Pharmacol.2022; 147:107125. (CAS, Q2，IF:5.738)

（13） Xiong X, Xia M, Niu A, Zhang Y, Yin T, Huang Q*.Dihydromyricetin contributes to weight loss via pro-browning mediated by mitochondrial fission in white adipose.Eur J Pharmacol. 2022;935:175345. doi:10.1016/j.ejphar.2022.175345. (CAS, Q2, TOP，IF:5.195)

（14） Yin T, Chen S, Zeng G, Yan W, Lu Y, Zhang Y, Huang QQ, Xiong X, Xu B*, Qiren Huang*. Angiogenesis-browning interplay mediated by asprosin-deficiency contributes to weight loss in mice with obesity. Int J Mol Sci.2022;23:16166. doi:10.3390/ ijms232416166. (CAS, Q1, TOP，IF:6.208)

（15） Wang Li, Zeng Wenjing, Wang Chaowen, Luo Zhenshuo, Huang Qiren*. Effect and mechanism of oxymatrine on human umbilical vein endothelial cells insulin resistance induced by palmitic acid. Chinese Traditional and Herbal Drugs, 2023;54(14):4530-4537.(CSCD-C) (In Chinese)

（16） Xia Min, Tu Yisi, Xiong Xiaowei, Niu Ailin,Yin Tingting, Zhang Yanan,Huang Qiren* . The role of Foxo6 in insulin resistance of vascular endothelial cells induced by high glucose and high fat and its interaction with NF-κB pathway. Chinese Pharmacological Bulletin, 2022; 38(4): 552-61. (CSCD-C) (In Chinese)

3. Academic Awards

(1) Effect of mechanism of Sasanquasaponin on adherence of leukocytes to stressed endothelial cells, Jiangxi Provincial Natural Science Award, Third (Z-09-3-08-R01), 2010.

(2) Protective effect and mechanism of Sasanquasaponin on experimental myocardial injury, Jiangxi Provincial Natural Science Award, Third (Z-106-02-3-01-R02), 2003.

(3) Effect of mechanism of Sasanquasaponin on adherence of leukocytes to stressed endothelial cells, Jiangxi Province University Science and Technology Achievement Award, Third (J090310), 2009.

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