Major Achievements | 1. Research Projects (Principal Investigator): [1] Key Project of Jiangxi Provincial Key R&D Program (2026-2028): “Study on the Screening and Evaluation of Traditional Chinese Medicine Based on Human Liver Organoid Disease Models” RMB 800,000. [2] National Administration of Traditional Chinese Medicine (2026-2028): “National Inheritance Workshop for Veteran Traditional Chinese Pharmacists” RMB 500,000. [3] Natural Science Foundation of Jiangxi Province (2026-2028) “Study on the Effect and Mechanism of Rhynchophylline on Methamphetamine Addiction by Inhibiting Microglia-mediated Neuroinflammation” RMB 100,000. [4] Jiangxi Medicine Academy of Nutrition and Health Management (2024-2027): “Immunomodulatory mechanism of peach gum polysaccharide based on gut immunity” RMB 200,000. [5] Jiangxi Provincial Administration of Traditional Chinese Medicine (2022-2024): “Jiangxi Provincial Young and Middle-aged Key Talent in Traditional Chinese Medicine” RMB 150,000. [6] Natural Science Foundation of China (2018-2021): “Study the effect and mechanism of rhynchophylline on improving methamphetamine-induced cognitive impairment based on the miR-124/NF-κB/AMPAR axis” RMB 340,000. [7] Natural Science Foundation of Jiangxi Province (2019-2021): “MiR-124 involves in methamphetamine-induced cognitive impairment by inhibiting neuroinflammation” RMB 60,000. [8] Natural Science Foundation of Jiangxi Province (2017-2020): “MiR-181a-5p in the hippocampus involves in methamphetamine addiction by suppressing GABRA1 and the interventional effects of rhynchophylline” RMB 60,000. 2. Representative Publications (First/Corresponding Author): [1] Chuanhua Feng*, Xiaolin Tang, Jian Zhou, Huiling Guo, Jinfang Hu, Guosong Zhang*, Mingjin Jiang*. Deep eutectic solvent: improve the constituents in Plantago asiatica L. (PAL) extract oral absorption in rats. Chemistry & biodiversity, 2025, e01611. Advance online publication. https://doi.org/10.1002/cbdv.202501611 [2] Jialing Shan, Weiqiong Hu, Qin Xie, Wei Bai, Tianyu Hu, Yanni Lv, Mingjin Jiang*. Exploring the mechanism of Sini San formula on ulcerative colitis and depression through “homotherapy for heteropathy” based on network pharmacology and molecular docking. Traditional Chinese Drug Research & Clinical Pharmacology, 2024; 35(1): 83-91. [3] Mingjin Jiang, Jing Li, Chaohua Luo, Chen Zhu, Zhijie Chen, Wei Bai, Tianyu Hu, Chuanhua Feng, Chan Li*, Zhixian Mo*. Rhynchophylline inhibits methamphetamine dependence via modulating the miR-181a-5p/GABRA1 axis. Journal of Ethnopharmacology, 2023; 314: 116635. [4] Mingjin Jiang, Zhu WangYanni Lv, Jianlan Hu, Jinfang Hu*. Rhynchophylline inhibits methamphetamine-induced addiction in rat pheochromocytoma cells by regulating microRNA-181a. Chinese Journal of Clinical Pharmacology, 2022; 38(17): 2055-2059. [5] Mingjin Jiang, Jinhua Wen, Decheng Pan, Jian Zhou, Yanni Lv, Xiaohua Wei*. Structure and function of SARS-CoV-2 spike protein and its receptor. Chinese Pharmacological Bulletin, 2020; 36(11): 1497-1501. [6] Mingjin Jiang, Duanwen Cao, Jian Zhou, Yanni Lv, Yaling Qiu, JinhuaWen, Xiaohua Wei*. MiR-124 involves in methamphetamine addiction in PC12 cells by inhibiting GluR2. Chinese Pharmacological Bulletin, 2017; 33(7): 982-986. [7] Mingjin Jiang#, Yifei Chen#, Chan Li, Qiuxian Peng, Miao Fang, Wei Liu, Qunzhao Kang, Yingbo Lin, Ken Kin Lam Yung, Zhixian Mo*. Inhibiting effects of rhynchophylline on zebrafish methamphetamine dependence are associated with amelioration of neurotransmitters content and down-regulation of TH and NR2B expression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2016, 68: 31-43. [8] Mingjin Jiang, Xiaohua Wei, Jinhua Wen, Zhixian Mo*. The study of sinomenine and methadone on the cardiotoxicity in zebrafish embryos. Pharmacology and Clinics of Chinese Materia Medica, 2016; 32(6): 70-72. [9] Mingjin Jiang, Chan Li, Yingbo Lin, Daoqi Zhu, Zhixian Mo*. Research progress on the role of miRNAs in amphetamine-type stimulants addiction. Chinese Pharmacological Bulletin, 2015; 31(10): 1352-1355. [10] Mingjin Jiang#, Jing Li#, Qiuxian Peng#, Yi Liu, Wei Liu, Chaohua Luo, Ju Peng, Junkui Li, Ken Kin Lam Yung*, Zhixian Mo*. Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation. Journal of Neuroinflammation, 2014, 11: 167. |