CURRICULUM VITAE

Zhangping Liao

Professor, MD, Ph.D. supervisor

School of Pharmaceutical Science,

Nanchang University

Tel: 86-13807915901

E-mail:liaozp@ncu.edu.cn

Major:Pharmacology

Research Interests: Mechanisms of myocardial ischemia/reperfusion injury and research on novel endogenous cardioprotective strategies. Mechanisms of myocardial injury induced by abnormal glucose and lipid metabolism. Cardioprotective effects of natural plant compounds.

EDUCATION

12/2014- 12/2015 Visiting Scholar, Pharmacology, Boston University School of Medicine, USA

9/2008- 12/2011 MD, Nutrition and Food Hygiene, Nanchang University, Nanchang 330006, P.R.China

9/2003 - 7/2006 M.S. Pharmacology, Nanchang University, Nanchang 330006, P.R.China

9/1998 - 7/2003 Bachelor of Medicine, Jiangxi Medical College, Nanchang 330006, P.R.China

Academic Positions

Director, Department of Pharmacology, School of Pharmacy, Nanchang University

Deputy Director, Jiangxi Province Key Laboratory of Drug Target Discovery and Validation

Professional Affiliations

Standing Committee Member, Jiangxi Pharmacological Society

Standing Committee Member, Basic Pharmacology Committee, Jiangxi Pharmaceutical Association

GRANTS

1. Investigation of resveratrol in regulating “VDAC1-Parkin-mitoNEET” axis mediated mitophagy-dependent ferroptosis in the event of myocardial ischemia/reperfusion injury. National Natural Science Foundation of China (NO. 82360643). 2024.1-2027.12

2. The role of “FGF21 resistance-VDAC1 axis” involved in myocardial ischemia/reperfusion vulnerability under obese condition. National Natural Science Foundation of China (NO. 82060657). 2021.1-2024.12

3. Studies on the regulation of PINK1/parkin-VDAC1 mitophagy signaling pathway in myocardial ischemia/reperfusion injury. National Natural Science Foundation of Jiangxi province (NO. 81660601). 2017.1-2020.12

4. Effect of resveratrol on the post-translational modification of VDAC1 in myocardial ischemia/reperfusion injury. National Natural Science Foundation of China (NO. 81460495). 2015.01-2018.12

5. Role of PBR-dependent ClICR in acute myocardial injury. National Natural Science Foundation of China (NO. 30960449). 2010.01-2012.12

6. Investigation of resveratrol in regulating mitophagy-dependent ferroptosis in the event of myocardial ischemia/reperfusion injury. Key Project of Jiangxi Province Natural Science Foundation (NO. 20232ACB206049). 2023.7-2027.7

7. The molecular mechanism research of the protective effect of resveratrol against myocardial ischemia/reperfusion injury based on PINK1-VDAC1-parkin mitophagy signaling pathway. Natural Science Foundation of Jiangxi Province (NO. 20202BAB206085). 2020.1-2022.12

8. Effect of resveratrol on phosphorylation of VDAC1 in myocardial ischemia/reperfusion injury. Natural Science Foundation of Jiangxi Province (NO. 20142BAB215016). 2014.01-2016.12

9. Study on the PBR-dependent ClICR mechanism in acute myocardial injury. Natural Science Foundation of Jiangxi Province (NO. 2009GQY0133). 2010.1-2012.12

PUBLICATION LIST

1. Zhou Y, Huang Y, Liang H, Yang X, Zhang S, Huang Y, Wan Y, Zhou H, Huang A, Chen Y, Li X, Peng Y, Liao Z. Resveratrol inhibits autophagy in cardiomyocytes subjected anoxia/reoxygenation injury: involved in VDAC1/PINK1/Parkin pathway. Toxicol Appl Pharmacol. 2025; 502: 117421.（Corresponding author）

2. Zhao Z, Cui X, Liao Z. Mechanism of fibroblast growth factor 21 in cardiac remodeling. Front Cardiovasc Med. 2023;10:1202730. （Corresponding author）

3. Xiaomei Yang, Yuancheng Zhou, Haiyan Liang, Yan Meng, Haocheng Liu , Ying Zhou, Chunhong Huang, Binyi An, Hongli Mao, Zhangping Liao. VDAC1 promotes cardiomyocyte autophagy in anoxia/ reoxygenation injury via the PINK1/Parkin pathway. Cell Biol Int. 2021 45(7): 1448-1458. （Corresponding author）

4. Meng Y, Tian M, Yin S, Lai S, Zhou Y, Chen J, He M, Liao Z. Downregulation of TSPO expression inhibits oxidative stress and maintains mitochondrial homeostasis in cardiomyocytes subjected to anoxia/reoxygenation injury. Biomed Pharmacother. 2020; 121:109588. （Corresponding author）

5. Tian M, Xie Y, Meng Y, Ma W, Tong Z, Yang X, Lai S, Zhou Y, He M, Liao Z. Resveratrol protects cardiomyocytes against anoxia/reoxygenation via dephosphorylation of VDAC1 by Akt-GSK3 β pathway. Eur J Pharmacol. 2019; 843:80-87. （Corresponding author）

6. Tong Z, Xie Y, He M, Ma W, Zhou Y, Lai S, Meng Y, Liao Z. VDAC1 deacetylation is involved in the protective effects of resveratrol against mitochondria-mediated apoptosis in cardiomyocytes subjected to anoxia/reoxygenation injury. Biomed Pharmacother. 2017,95:77-83. （Corresponding author）

7. Zhangping Liao, Huan He, Guohua Zeng, Dan Liu, Lei Tang, Dong Yin, Dong Chen, Ming He. Delayed protection of Ferulic acid in isolated hearts and cardiomyocytes: Upregulation of heat-shock protein 70 via NO-ERK1/2 pathway. Journal of Functional Foods. 2017, 34: 18-27.

8. Liao Z, Liu D, Tang L, Yin D, Yin S, Lai S, Yao J, He M. Long-term oral resveratrol intake provides nutritional preconditioning against myocardial ischemia/reperfusion injury: involvement of VDAC1 down-regulation. Mol Nutr Food Res. 2015, 59(3): 454-64.

9. Guo Z, Liao Z, Huang L, Liu D, Yin D, He M. Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1. Eur J Pharmacol. 2015; 761:245-53. （Co-first author）

10. Liu LP, Liao ZP, Yin D, Li WD, Liu D, Li Q, Huang QR, Yang YF, He M. The protective effects of Polygonum multiflorum stilbeneglycoside preconditioning in an ischemia/reperfusion model of HUVECs. Acta Pharmacol Sin. 2010;31(4):405-12. （Co-first author）

11. Liao Z, Yin D, Wang W, Zeng G, Liu D, Chen H, Huang Q, He M. Cardioprotective effect of sasanquasaponin preconditioning via bradykinin-NO pathway in isolated rat heart. Phytother Res. 2009; 23(8):1146-53.

12. Zhou QL, Song Y, Huang CH, Huang JY, Gong Z, Liao Z, Sharma AG, Greene L, Deng JZ, Rigor MC, Xie X, Qi S, Ayala JE, Jiang ZY. Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release. Mol Cell Biol. 2018. pii: MCB.00153-17.

13. He H, Qiao Y, Zhang Z, Wu Z, Liu D, Liao Z, Yin D, He M. Dual action of vitamin C in iron supplement therapeutics for iron deficiency anemia: prevention of liver damage induced by iron overload. Food Funct. 2018, 9(10): 5390-5401.

14. He H, Zhou Y, Huang J, Wu Z, Liao Z, Liu D, Yin D, He M. Capsaicin Protects Cardiomyocytes against Anoxia/Reoxygenation Injury via Preventing Mitochondrial Dysfunction Mediated by SIRT1. Oxid Med Cell Longev. 2017; 2017:1035702.

15. Huang JY, Zhou QL, Huang CH, Song Y, Sharma AG, Liao Z, Zhu K, Massidda MW, Jamieson RR, Zhang JY, Tenen DG, Jiang ZY. Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity. J Biol Chem. 2017, 292(12):4770-4776.

16. Li YY, Xiao L, Qiu LY, Yan YF, Wang H, Duan GL, Liao ZP, Chen HP. Sasanquasaponin-induced cardioprotection involves inhibition of mPTP opening via attenuating intracellular chloride accumulation. Fitoterapia. 2017, 116:1-9

17. Qiao Y, He H, Zhang Z, Liao Z, Yin D, Liu D, Yi B, He M. Long-Term Sodium Ferulate Supplementation Scavenges Oxygen Radicals and Reverses Liver Damage Induced by Iron Overloading. Molecules. 2016; 21(9). pii: E1219.

18. Zhang Z, Liu D, Yi B, Liao Z, Tang L, Yin D, He M. Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model. Mol Med Rep. 2014, 10(5): 2255-62.

19. Huang XS, Chen HP, Yu HH, Yan YF, Liao ZP, Huang QR. Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for hypoxic preconditioning-mediated delayed cardioprotection. Mol Cell Biochem. 2014, 385(1-2):33-41.

20. Liu D, Yi B, Liao Z, Tang L, Yin D, Zeng S, Yao J, He M. 14-3-3γ protein attenuates lipopolysaccharide-induced cardiomyocytes injury through the Bcl-2 family/mitochondria pathway. Int Immunopharmacol. 2014, 21(2): 509-515.

21. Liu D, He H, Yin D, Que A, Tang L, Liao Z, Huang Q, He M. Mechanism of chronic dietary iron overload-induced liver damage in mice. Mol Med Rep. 2013, 7(4): 1173-9.

22. Liu D, He H, Li GL, Chen J, Yin D, Liao ZP, Tang L, Huang QR, Lai ZF, He M. Mechanisms of chloride in cardiomyocyte anoxia-reoxygenation injury: the involvement of oxidative stress and NF-kappaB activation. Mol Cell Biochem, 2011, 355 (1-2): 201-209.

23. Chen HP, Liao ZP, Huang QR, He M. Sodium ferulate attenuates anoxia/reoxygenation-induced calcium overload in neonatal rat cardiomyocytes by NO/cGMP/PKG pathway. Eur J Pharmacol. 2009; 603(1-3):86-92.

24. Chen HP, He M, Xu YL, Huang QR, Zeng GH, Liu D, Liao ZP. Anoxic preconditioning up-regulates 14-3-3 protein expression in neonatal rat cardiomyocytes through extracellular signal-regulated protein kinase 1/2. Life Sci. 2007, 12; 81(5):372-9.

25. Liao Zhangping, He Ming, Shao Lijian, Lai Zhongfang. Role of AE2 Protein in the Myocardial anoxia-reoxygenation Injury and Ischemic Preconditioning. Acta Pharmacol Sin. 2006, 27(s):254.