Yong Chen, Ph.D.
Professor of Cell Biology, Pharmaceutics/Pharmacology, and Nanotechnology/Nanomedicine
Affiliation: School of Pharmacy, Nanchang University, Nanchang, Jiangxi330031, China
Work Address: 999 Xuefu Ave., Honggutan District, Nanchang, Jiangxi 330031, China
Email address: tychen@ncu.edu.cn or dr_yongchen@hotmail.com
Websites:
1. ResearchGate: https://www.researchgate.net/profile/Yong-Chen-21
2. Web of Science: https://www.webofscience.com/wos/author/record/A-8143-2008
3. YongChenLab: http://www.labxing.com/yongchenlabatncu (Chinese)
4. Institutional webpage: https://yxy.ncu.edu.cn/info/2271/16031.htm (Chinese)
Research fields:
Bioinspired drug delivery systems, lipid and lipoprotein metabolism (particularly atherosclerotic cardiovascular diseases), pharmaceutics and pharmacology, cell biology, biological fluorescent probes, and others
Education:
2000-2003 Ph.D. Chinese Academy of Sciences, China
1997-2000 M.S. Department of Bioengineering, Jinan University, Guangdong, China
1993-1997 B.Sc. Department of Biology, Nanchang University, Jiangxi, China
Professional Experience:
2024/07-present: Professor, School of Pharmacy, Nanchang University, Jiangxi, China
2017/12-2019/01:Visting scholar, Department of Cell Biology, SUNY (State University of New York) Downstate Medical Center, NY, USA.
2013/01~2024/07: Professor, Institute for Advanced Study, Nanchang University, Jiangxi, China.
2009/03~2013/12: Specially-appointed Professor and Full-time Professor, Institute for Advanced Study, Nanchang University, Jiangxi, China; College of Life Sciences, Nanchang University, Jiangxi, China.
2008/04~2009/03: Research Assistant Professor, Center for Primate Biomedical Research, University of Illinois at Chicago, Chicago, IL, USA.
2004/09~2008/04: Postdoctoral Fellow, Department of Microbiology & Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA
2003/08~2004/09: Instructor, Department of Chemistry, Jinan University, Guangdong, China.
Editorship for scientific journals
1. Editorial Board Member (EBM): <Pharmaceutics>, <BMC Molecular and Cell Biology>, <Mini-Reviews in Medicinal Chemistry>, <Current Drug Delivery> (Section Editor), <Experimental and Therapeutic Medicine>, <Cardiovascular Innovations and Applications>, <AIMS Medical Science>, <Sumerianz Journal of Biotechnology> (Associate Editor), etc.
2. Guest Editor/Advisor/Editor-in-Chief: <Pharmaceutical Biology>, <International Journal of Molecular Sciences>, <Frontiers in Pharmacology>, etc.
3. Invited reviewer for more than 100 journals: <Advanced Functional Materials>, <Advanced Science>, <Cell Research>, <Small>, <Biomaterials>, <Carbohydrate Polymers>, <Journal of Nanobiotechnology>, <EMBO Molecular Medicine>, <Chemical Engineering Journal>, <Journal of Advanced Research>, etc.
Ongoing Research Fundings: (The Principle Investigator of >20 grants)
National Natural Science Foundation of China (NSFC): In situ investigation on the mechanisms of aggregated low-density lipoprotein formation at the nanoscale (2025.01-2028.12)
Peer-reviewed publications since 2020:
(out of >100 papers; # co-first authors; * corresponding authors)
1) Kun Wang, Chenhan Sun, Hongda Zhuang, Xian-Cheng Jiang, Yong Chen*. AFM reveals differential effects of acidification on LDL- and oxidized LDL-receptor interactions: Biomechanical Implications in atherogenesis. Cellular & Molecular Biology Letters. 2025. 30: 32
2) Mengyi Lan, Yuan Zhang, Yong Chen*, Solving the contamination conundrum derived from coisolation of extracellular vesicles and lipoproteins: Approaches for isolation and characterization. Small Methods. 2025. 9: e01606
3) Yuan Zhang, Wendiao Zhang, Zhiwen Wu, Yong Chen*. Diversity of extracellular vesicle sources in atherosclerosis: Role and therapeutic application. Angiogenesis. 2025. 28: 34
4) Chenhan Sun, Qinghua Sheng, Ying Qin, Yong Chen*. Single-aggregate morphological and biomechanical detection of atherogenic aggregated low-density lipoprotein (agLDL) by atomic force microscopy. Colloids and Surfaces B: Biointerfaces. 2025. 254: 114864
5) Yuanfang Li#, Yuan Zhang#, Mengyi Lan, Zhilu Fan, Tingting Gong, Langtao Xu, Tong Rong, Kun Wang, Huaying Wang, Meiying Ao, Yong Chen*. Anti-atherosclerotic effect of lipid/cholesterol-cyclodextin inclusion complexes similar to free cyclodextrin in ApoE-/- mice fed a high-fat diet. Carbohydrate Polymer Technologies and Applications. 2025. 10: 100811
6) Haonan Zhao#, Zhendong Huang#, Qinghua Sheng, Wenxiang Shao, Min Zeng, Kun Wang, Yang Zhang, Ying Qin, Zhihao Xiong, Lizhen Chen, Huaying Wang, Tong Rong, Zhitao Qiu, Hongda Zhuang, Zhiwen Wu, Yuan Zhang, Wendiao Zhang*, Yong Chen*. Enhanced anti-tumour efficacy of iRGD-modified cell-bound membrane vesicles (iRGD-CBMVs) as a novel drug carrier. Journal of Extracellular Biology. 2025. 4: e70052
7) Lang W#, Wu Z#, Li J#, Chen Y*, Cao Q*. A novel coumarin-linked tetraphenylethene fluorescent probe for simultaneous sensing of ATP and GSH. Sensors and Actuators: B. Chemical. 2024. 412: 135772
8) Wu J, Li J, Shao W, Hu Y, Chen H, Chen Y, Chen Y, Liu Q, Ao M*. Cyclodextrins as therapeutic drugs for treating lipid metabolism disorders. Obesity Reviews. 2024. 25(4): e13687
9) Sun C, Qin Y, Zhuang H, Zhang Y, Wu Z, Chen Y*. Membrane vesicles as drug delivery systems: Source, preparation, modification, drug loading, in vivo administration and biodistribution, and application in various diseases. Pharmaceutics. 2023. 15(7): 1903
10) Lang W#, Chen L#, Chen Y*, Cao Q*. A GSH-activated AIE-based polymer photosensitizer for killing cancer cells. Talanta. 2023. 258: 124473
11) Wang K#, Li Z., Egini O., Wadgaonkar R., Jiang X*, Chen Y#,*. Atomic force microscopy reveals involvement of the cell envelope in biomechanical properties of sickle erythrocytes. BMC Biology. 2023. 21: 31
12) Min Gao, Le Zeng, Linhan Jiang, Mingyu Zhang, Yong Chen*, Ling Huang*. Bodipy dimer for enhancing triplet-triplet annihilation upconversion performance. Molecules. 2023. 28(14): 5474
13) Zhou Y#, Qin Y#, Sun C., Liu K., Zhang W., Gaman M.A., Chen Y*. Cell-bound membrane vesicles contain antioxidative proteins and probably have an antioxidative function in cells or a therapeutic potential. Journal of Drug Delivery Science and Technology. 2023. 81: 104240
14) Qin Y#, Zhou Y#, Wang K., Gu J., Xiong Z., Zhang W., Chen Y*. In situ isolation of nuclei or nuclear proteins from adherent cells: A simple, effective method with less cytoplasmic contamination. Biological Research. 2023. 56: 18
15) Bai H#, Xiong Z#, Zhou F#, Qin J., Wen S., Li Z*, Chen Y*, Cao Q*. An amphiphilic tetraphenylethylene-based photosensitizer for cancer cell ablation and bacteria killing. Dyes and Pigments. 2022. 206: 110652.
16) Wei B., Li Y., Ao M., Shao W., Wang K., Rong T., Zhou Y., Chen Y*. Ganglisoide GM3-functionalized reconstituted high-density lipoprotein (GM3-rHDL) as a novel nanocarrier enhances antiatherosclerotic efficacy of statins in apoE-/- C57BL/6 mice. Pharmaceutics. 2022. 14(11): 2534
17) Li Y#, Zhou J#, Gu J, Shao Q, Chen Y*. Enhanced antibacterial activity of levofloxacin/hydroxypropyl-b-cyclodextrin inclusion complex: In vitro and in vivo evaluation. Colloids and Surfaces B: Biointerfaces. 2022. 215: 112514.
18) Lang W#, Zhou F#, Chen Y*, Cao Q*. A new poly(norbornene)-based sensor for fluorescent ratiometric sensing of adenosine 5’-triphosphate. Dyes and Pigments. 2022. 200: 110187.
19) Li X#, Wang H#, Zhang Y, Cao Q*, Chen Y*. A GSH-responsive PET-based fluorescent probe for cancer cells imaging. Chinese Chemical Letters. 2021. 32(4): 1541-1544
20) Wang K, Gan C, Wang H, Ao M, Fan Y, Chen Y*. AFM detects the effects of acidic condition on the size and biomechanical properties of native/oxidized low-density lipoprotein. Colloids and Surfaces B: Biointerfaces. 2021. 208: 112053 (cover paper).
21) Rong T, Wei B, Ao M, Zhao H, Li Y, Zhang Y, Qin Y, Zhou J, Zhou F, Chen Y*. Enhanced anti-atherosclerotic efficacy of pH-responsively releasable ganglioside GM3 delivered by reconstituted high-density lipoprotein. International Journal of Molecular Sciences. 2021. 22(24): 13624.
22) Chen G#, Zhou Y#, Zhang W, Wei B, Sun Y, Chen Y*. Methyl-b-cyclodextrin suppresses the monocyte-endothelial adhesion triggered by lipopolysaccharide or oxidized low-density lipoprotein. Pharmaceutical Biology. 2021. 59(1): 1036-1044.
23) Wang K#, Qin Y#, Chen Y*. In situ AFM detection of the stiffness of the in situ exposed cell nucleus. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research. 2021. 1868(5): 118985.
24) Li Z#, Chiang Y#, He M, Zhang K, Zheng J, Wu W, Cai J, Chen Y, Chen G, Chen Y, Dong J, Worgall TS, Jiang XC*. Effect of liver total sphingomyelin synthase deficiency on plasma lipid metabolism. BBA – Molecular and Cell Biology of Lipids. 2021. 1866 (5): 158898
25) Wang K, Li Y, Luo C, Chen Y*. Dynamic AFM detection of the oxidation-induced changes in size, stiffness, and stickiness of low-density lipoprotein. Journal of Nanobiotechnology. 2020. 18: 167
26) Zhang W#, Gu J#,*, Li Y, Shan W, Xu Y, Chen Y*. Single-vesicle tracking reveals the potential correlation of the movement of cell-bound membrane vesicles (CBMVs) with cell migration. BBA-Molecular Cell Research. 2020.1867 (11): 118804
27) Zhang Y, Liu Y, Zhang W, Tang Q, Zhou Y, Li Y, Rong T, Wang H, Chen Y*. Isolated cell-bound membrane vesicles (CBMVs) as a novel class of drug nanocarriers. Journal of Nanobiotechnology. 2020. 18(1): 69
28) Guo Q#, Zhang Y#, Lin Z, Cao Q*, Chen Y*. Fluorescent norbornene for sequential detection of mercury and biothiols. Dyes and Pigments. 2020. 172: 107872 (a highly cited paper in 2020)
29) Cheng TH, Puskarich M, Li X, Fang Z, Xu F, Chen Y, Jiang XC, Worah S, Jones AE, Zhang M*. Circulating complement C3-alpha chain levels predict survival of septic shock patients. Shock. 2020. 54(2):190-197
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