Liping Jiang,Professor

Liping Jiang

Name: Liping Jiang

Title: Professor(Second-Level Professor)

Email: lpjiang@ncu.edu.cn

Hometown: Zhenjiang, Jiangsu

Supervisor Type: Doctoral Supervisor

Courses Taught: "Pharmacology", "Advanced Pharmacology VI (Progress in Pharmacological Research)", "Advanced Pharmacology I (Cardiovascular Pharmacology)", "Progress in Drug Targets and Screening Research"

Research Directions:

Cardiovascular and Cerebrovascular Pharmacology, Tumor Pharmacology

Education:

Sep 1981 - Jun 1986: Clinical Medicine Undergraduate, Nantong University Medical College, Bachelor of Medicine

Sep 1986 - Jun 1989: Master of Pharmacology, Nantong University (Suzhou University) Medical College, Master of Medicine

Sep 2002 - Jun 2005: Ph.D. in Pharmacology, Shanghai Jiao Tong University School of Medicine, Doctor of Medicine

Work Experience:

Jul 1989 - Present: Professor, Department of Pharmacology, School of Pharmacy, Nanchang University (formerly Department of Basic Sciences, Jiangxi Medical College)

Jan 2000 - Dec 2005: Deputy Director, Graduate School, former Jiangxi Medical College

Jan 2006 - Jun 2007: Deputy Director, Office of Science and Technology, Nanchang University & Director, Medical Science and Technology Department

Jun 2007 - Aug 2015: Director, Office of International Cooperation and Exchange, Nanchang University

May 2011 - Nov 2011: Visiting Scholar, Cardiovascular Disease Research Center, Brigham and Women's Hospital, Harvard Medical School, USA

Jul 2012 - Sep 2012: Academic Visit, University of Colorado School of Medicine, USA

Sep 2015 - Jun 2023: Dean, School of Pharmacy, Nanchang University

Academic Affiliations:

Member, Teaching Guidance Committee for Pharmacy Majors in Higher Education Institutions, Ministry of Education

Director, Basic Pharmacology Professional Committee, Jiangxi Pharmaceutical Association

President, Nanchang Pharmaceutical Association

Standing Committee Member, Professional Committee of Microcirculation Drug Research, Chinese Society of Microcirculation

Deputy Director, Teaching Guidance Committee for Pharmacy Majors, Jiangxi Province

Member, Cardiovascular Pharmacology Professional Committee, Chinese Pharmacological Society

Standing Council Member, Jiangxi Pharmaceutical Association

Standing Council Member, Jiangxi Society for Neuroscience

Member, Expert Committee, Jiangxi Strategic Alliance for Industry-Education Integration in Traditional Chinese Medicine Industry

Personal Honors:

2001: Middle-aged and Young Backbone Teachers in Jiangxi Provincial Universities

2004: Title of "Nomination of Jiangxi Young Scientists" at the First Jiangxi Young Scientists Academic Annual Conference

2006: Young and middle-aged academic leaders in universities in Jiangxi Province

2008: Selected for Jiangxi Provincial Hundred, Thousand, and Ten Thousand Talents Program

2021: Three Hundred Talents of Nanchang University (Xiangzhang Jiecai)

2023:Excellent Master's Thesis Supervisor at Nanchang University

2025:Outstanding Doctoral Dissertation Supervisor at Nanchang University

Major Achievements:

(Personally Hosted Projects, Representative Papers, Patents, Publications, Awards):

1. Hosted Research Projects:

[1] Jiang Liping. Mechanism of TBC1D15 regulating MLC to affect lysosomal Ca2+ dynamics and downregulate Cx43 expression in glioma TMZ resistance, National Natural Science Foundation of China, 82460719, 320,000 CNY, Jan 1, 2025 - Dec 31, 2028, Ongoing, Host.

[2] Jiang Liping. Role and mechanism of mtCx43/MCU in mitochondrial autophagy induced by myocardial ischemia-reperfusion injury, National Natural Science Foundation of China, 82160686, 340,000 CNY, Jan 2022 - Dec 2025.

[3] Jiang Liping. Role and mechanism of HIF-1α upregulating Cx43 expression under hypoxic conditions in pulmonary arterial hypertension, National Natural Science Foundation of China, 81660014, 360,000 CNY, Jan 2017 - Dec 2020.

[4] Jiang Liping. Experimental study on inhibiting vascular restenosis by RNA interference silencing Cx43 gene expression, National Natural Science Foundation of China, 30760286, 180,000 CNY, Jan 2008 - Dec 2010.

[5] Jiang Liping. Jiangxi Key Laboratory of Drug Targets and Screening, 2017, Jiangxi Provincial Department of Science and Technology, 300,000 CNY; Received excellence award in the evaluation of provincial key laboratories and engineering technology research centers established in 2016-2017, 2021, 500,000 CNY.

[6] Jiang Liping. Mechanism of mitochondrial Cx43–MCU-Ca++ signaling in H2O2-induced oxidative stress injury in cardiomyocytes, Key Project of Jiangxi Provincial Natural Science Foundation, 200,000 CNY, Jan 2020 - Dec 2023, 20202ACB206001.

[7] Jiang Liping. Role and mechanism of hypoxia-upregulated Cx43 expression in PAH pulmonary vascular remodeling, General Project of Jiangxi Provincial Key Research and Development Program, 100,000 CNY, Jan 2019 - Dec 2022, 20192BBG70012.

[8] Hong Tao, Jiang Liping. Mechanism of gap junction involvement in cerebral microcirculation dysfunction after subarachnoid hemorrhage, National Natural Science Foundation of China, 81560207, Jan 2016 - Dec 2019.

[9] Hong Tao, Jiang Liping. Mechanism of gap junction network as a common pathway in cerebral vasospasm, National Natural Science Foundation of China, 81241125, Jan 2013 - Dec 2013.

[10] Hong Tao, Jiang Liping. Study on the role of gap junction protein phosphorylation in cerebral vasospasm, National Natural Science Foundation of China, 81060099, Jan 2010 - Dec 2013.

[11] Hong Tao, Jiang Liping. Study on the molecular mechanism of gap junction remodeling involved in cerebral vasospasm, National Natural Science Foundation of China, 30660188, Jan 2007 - Dec 2009.

[12] Hong Tao, Jiang Liping. Mechanism of gap junction involvement in the formation of cerebral vasospasm, National Natural Science Foundation of China, 30360105, Jan 2004 - Dec 2006.

[13] Hong Tao, Jiang Liping. Role of gap junction in cerebral vasospasm, National Natural Science Foundation of China, 39960076, Jan 2000 - Dec 2002.

[14] National "Eleventh Five-Year" Science and Technology Support Program Project "Research and Application of Suitable Technologies and Products for Rural Health", Project Name: Research on Prevention and Treatment of Common and Frequently Occurring Diseases such as Childhood Asthma, Project No.: 2007BA107A04, Participant, Passed expert acceptance organized by the Ministry of Science and Technology in September 2012.

[15] Jiang Liping. Study on the molecular mechanism of differential expression of connexin proteins involved in vasospasm, Jiangxi Provincial Natural Science Foundation, 20,000 CNY, Jan 2014 - Dec 2016, 20142BAB205022.

[16] Jiang Liping. Signaling pathway mechanism of panaxynol inhibiting proliferation of rat aortic smooth muscle cells, Jiangxi Provincial Natural Science Foundation, 20,000 CNY, Jul 2006 - Jun 2009.

[17] Jiang Liping. Study on the effect of specific gap junction blockers on cerebral vasospasm, Jiangxi Provincial Natural Science Foundation, 20,000 CNY, Jul 2000 - Jun 2003.

[18] Jiang Liping. Study on the effects of protopine-summer none monomer alkaloids on cerebral and peripheral blood vessels, Youth Project of Jiangxi Provincial Natural Science Foundation, 10,000 CNY, Jul 1993 - Jun 1996.

[19] Jiang Liping. Role of connexin 43 phosphorylation in ET-1-induced proliferation and migration of vascular smooth muscle cells, Jiangxi Provincial Department of Education, 20,000 CNY, Jan 2011 - Dec 2013.

[20] Jiang Liping. Molecular mechanism of panaxynol inhibiting vascular smooth muscle cell proliferation, Key Project of Jiangxi Provincial Department of Education, 100,000 CNY, Jan 2007 - Dec 2009.

2. Representative Publications:

[1] Yunyan Du, Zhangjian Yang, Hao Shi, Zhihan Chen, Rong Chen, Fan Zhou, Xiaogang Peng, Tao Hong, Liping Jiang*. E3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA. Cell Death Dis. 2024 May 16;15(5):340. doi: 10.1038/s41419-024-06729-z.

[2] Hani Ahmed, Mohamed Y Zaky, Marwan M A Rashed, Marwan Almoiliqy, Sam Al-Dalali, Zienab E Eldin, Mohanad Bashari, Ahmad Cheikhyoussef, Sulaiman A Alsalamah, Mohammed Ibrahim Alghonaim, Abdulrahman M Alhudhaibi, Jinpeng Wang, Li-Ping Jiang. UPLC-qTOF-MS phytochemical profile of Commiphora gileadensis leaf extract via integrated ultrasonic-microwave-assisted technique and synthesis of silver nanoparticles for enhanced antibacterial properties. Ultrason Sonochem 2024 Jul:107:106923. doi: 10.1016/j.ultsonch.2024.106923. Epub 2024 May 25.

[3] Zhang-Jian Yang, Wei-Fang Zhang, Qing-Qing Jin, Zhi-Rong Wu, Yun-Yan Du, Hao Shi, Zhen-Sheng Qu, Xiao-Jian Han*, Li-Ping Jiang*. Lactate Contributes to Remote Ischemic Preconditioning-Mediated Protection Against Myocardial Ischemia Reperfusion Injury by Facilitating Autophagy via the AMPK-Mammalian Target of Rapamycin-Transcription Factor EB-Connexin 43 Axis. Am J Pathol, 2024 Oct;194(10):1857-1878. PMID: 39069170, doi: 10.1016/j.ajpath.2024.07.005. Epub 2024 Jul 26.

[4] Hani Ahmed, Marwan M. A. Rashed, Marwan Almoiliqy, Mohammed Abdalla, Mohanad Bashari, Mohamed Y. Zaky, Zhu Hailin, Taha A. A. Naji, Ahmed Eibaid, Jinpeng Wang, Li-Ping Jiang*. Antioxidant activity and total phenolic compounds of Commiphora gileadensis extracts obtained by ultrasonic-assisted extraction, with monitoring antiaging and cytotoxicity activities. Food Sci Nutr. 2023;00:1--10. DOI: 10.1002/fsn3.3339

[5] Yang ZJ, Liu R, Han XJ, Qiu CL, Dong GL, Liu ZQ, Liu LH, Luo Y, Jiang LP*. Knockdown of the long noncoding RNA MALAT1 ameliorates TNFαmediated endothelial cell pyroptosis via the miR30c5p/Cx43 axis. Mol Med Rep. 2023 Apr;27(4):90-102. doi: 10.3892/mmr.2023.12977. Epub 2023 Mar 10.

[6] Zhang K, Wang T, Sun GF, Xiao JX, Jiang LP, Tou FF, Qu XH, Han XJ*. Metformin protects against retinal ischemia/reperfusion injury through AMPK-mediated mitochondrial fusion. Free Radic Biol Med. 2023 May 28;205:47-61. doi: 10.1016/j.freeradbiomed.2023.05.019.

[7] Yang ZJ, Bi QC, Gan LJ, Zhang LL, Wei MJ, Hong T, Liu R, Qiu CL, Han XJ, Jiang LP*. Exosomes Derived from Glioma Cells under Hypoxia Promote Angiogenesis through Up-regulated Exosomal Connexin 43. Int J Med Sci. 2022 Jul 4;19(7):1205-1215. doi: 10.7150/ijms.71912. eCollection 2022.

[8] Xiao YY, Xiao JX, Wang XY, Wang T, Qu XH, Jiang LP, Tou FF, Chen ZP, Han XJ*. Metformin-induced AMPK activation promotes cisplatin resistance through PINK1/Parkin dependent mitophagy in gastric cancer. Front Oncol. 2022 Oct 25;12:956190. doi: 10.3389/fonc.2022.956190. eCollection 2022. PMID: 36387221

[9] Hua F, Xiao YY, Qu XH, Li SS, Zhang K, Zhou C, He JL, Zhu Y, Wan YY, Jiang LP, Tou FF, Han XJ*. Baicalein sensitizes triple negative breast cancer MDA-MB-231 cells to doxorubicin via autophagy-mediated down-regulation of CDK1. Mol Cell Biochem. 2022 Nov 21. doi: 10.1007/s11010-022-04597-9. Online ahead of print. PMID: 36413334

[10] Zou GP, Wang T, Xiao JX, Wang XY, Jiang LP, Tou FF, Chen ZP, Qu XH, Han XJ*. Lactate protects against oxidative stress-induced retinal degeneration by activating autophagy. Free Radic Biol Med. 2023 Jan;194:209-219. doi: 10.1016/j.freeradbiomed.2022.12.004. Dec 7. PMID: 36493984

[11] Zhang K, Guo MY, Li QG, Wang XH, Wan YY, Yang ZJ, He M, Yi YM, Jiang LP, Qu XH, Han XJ*. Drp1-dependent mitochondrial fission mediates corneal injury induced by alkali burn. Free Radic Biol Med. 2021 Nov 20:176:149-161. doi: 10.1016/j.freeradbiomed.2021.09.019. Epub 2021 Sep 22. PMID: 34562609

[12] Han XJ, Zhang WF, Wang Q, Li M, Zhang CB, Yang ZJ, Tan RJ, Gan LJ, Zhang LL, Lan XM, Zhang FL, Hong T, Jiang LP*. HIF-1α promotes the proliferation and migration of pulmonary arterial smooth muscle cells via activation of Cx43. J Cell Mol Med. 2021 Nov;25(22):10663-10673. doi: 10.1111/jcmm.17003. Epub 2021 Oct 26. PMID: 34698450

[13] Yang ZJ, Zhang LL, Bi QC, Gan LJ, Wei MJ, Hong T, Tan RJ, Lan XM, Liu LH, Han XJ, Jiang LP*. Exosomal connexin 43 regulates the resistance of glioma cells to temozolomide. Oncol Rep. 2021 Apr;45(4):44. doi: 10.3892/or.2021.7995. Epub 2021 Mar 2. PMID: 33649836

[14] Min Jun Wei, Jiu Geng Feng, Zhi Qun Jiang, Chun Hui Zeng, Li Ping Jiang*, Tao Hong*. Identification of OPN, TNC and E-selectin as potential recognition proteins in cerebral vasospasm after subarachnoid hemorrhage. Chinese Neurosurgical Journal, 2016(18 June);2:17

[15] Han XJ, Chen M, Hong T, Zhu LY, He D, Feng JG, Jiang LP*. Lentivivirus-mediated RNAi knockdown of gap junction protein Cx43 attenuates vascular restenosis after balloon injury. Int J Mol Med. 35(4): 885-892, 2015

[16] Xiao-Jian Han, Dan He, Liang-Jing Xu, Min Chen, Yi-Qi Wang, Jiu-Geng Feng, Min-Jun Wei, Tao Hong, Li-Ping Jiang*. Knockdown of connexin 43 attenuates balloon injury-induced vascular restenosis through the inhibition of the proliferation and migration of vascular smooth muscle cells. Int J Mol Med. 36(5):1361-1368, 2015

[17] Han XJ, Yang ZJ, Jiang LP, Wei YF, Liao MF, Qian Y, Li Y, Huang X, Wang JB, Xin HB and Wan YY. Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells. Int J Oncol. 2015;46(2):691-700

[18] Wan YY, Zhang JF, Yang ZJ, Jiang LP, Wei YF, Lai QN, Wang JB, Xin HB, Han XJ*. Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells. Oncol Rep. 2014;32(2):619-626

[19] Han XJ, Wei YF, Wan YY*, Jiang LP, Zhang JF, Xin HB. Development of a novel liposomal nanodelivery system for bioluminescence imaging and targeted drug delivery in ErbB2-overexpressing metastatic ovarian carcinoma. Int J Mol Med. 2014;34(5):1225-1232

[20] Liping Jiang*, L Zhu, T Hong, J Feng. The effect of connexin 43 remolding in vascular restenosis. Basic & clinical pharmacology & Toxicology, 2010;107(suppl.1):357

[21] Li-Ping Jiang*, Yang Lu, Bao-Ming Nie. Inhibitory effect of panaxynol on the proliferation of rat aortic smooth muscle cell and its mechanisms. Journal of Pharmacological Sciences, 2009;109(1):282

[22] Jiang Liping*，Lu Yang，Chen Hongzhuan. Inhibitory effect of panaxynol on the proliferation of rat aortic smooth muscle cell and its mechanisms, 82nd Annual Meeting of the Japanese-Pharmacological-Society, 282P, Yokohama, JAPAN, Mar 16, 2009 - Mar 18, 2009

[23] Li-Ping Jiang, Yang Lu, Bao-Ming Nie, Hong-Zhuan Chen. Antiproliferative effect of Panaxynol on RASMCs via inhibition of ERK1/2 and CREB. Chemico-Biological Interactions 171(2008), 348-354

[24] Li YR, Pang XM, Li M, Wang Q, Yang YQ, Han XJ, Jiang LP*. Effect and mechanism of Cx43 on the proliferation of glioma C6 cells. Chinese Pharmacological Bulletin. 2017;33(7):1008-13.

[25] Tang R, Jiang LP*, Hong T. Connexin 43 and Glioma. Chinese Pharmacological Bulletin. 2012;28(12):1648-51.

[26] Chen M, He D, Feng JG, Tang R, Hong T, Jiang LP*. Inhibition of vascular restenosis by RNA interference silencing Cx43 gene expression. Chinese Journal of Pharmacology and Toxicology. 2011;25(suppl):23.

[27] Chen M, Jiang LP*, Hong T. Role of connexins in the formation and prevention of atherosclerosis. Chinese Pharmacological Bulletin. 2010;26(10):1271-4.

[28] Shan RA, Zhan LF, Jiang LP*. Research progress on hypertonic saline compound solutions. Guangdong Medical Journal. 2010;(12):1619-22.

[29] Shan RA, Jiang LP*, Zeng J, Huang ZH. Protective effect of hypertonic sodium chloride hydroxyethyl starch 40 injection on cerebral ischemia-reperfusion injury in rats. Shandong Medical Journal. 2010;(14):36-7.

[30] Zhu LY, Jiang LP*. New targets for the prevention and treatment of vascular restenosis. Chinese Journal of New Drugs and Clinical Remedies. 2008;27(6):446-9.

[31] Gan LJ, Jiang LP*, Xia Y, Lu Y. Effects of panaxydol epoxide on VSMCs migration and mitochondrial transcription factor 1 mRNA expression. Pharmacology and Clinics of Chinese Materia Medica. 2007;23(5):46-8.

[32] Jiang LP, Nie BM, Lu HM, Gan LJ, Chen HZ, Lu Y. Inhibitory effect and mechanism of panaxynol on the proliferation of rat aortic smooth muscle cells. Chinese Pharmacological Bulletin. 2005;21(11):1313-9.

[33] Jiang LP, Chen HZ, Lu Y. Research progress on lipoxygenase and its inhibitors. Chinese Pharmacological Bulletin. 2005;21(8):897-901.

[34] Jiang LP, Han XJ, Chen XY, Yu XC, Feng GH. Protective effect of protopine on cerebral ischemia. Pharmacology and Clinics of Chinese Materia Medica. 2004;20(1):9-11.

[35] Jiang LP, Han XJ, Hong T. Inhibitory effect of the gap junction blocker heptanol on ET-induced contraction of rat mesenteric arteries. Chinese Pharmacological Bulletin. 2004;20(11):1313-4.

[36] Jiang LP, Han XJ, Hong T. Role of gap junctions in the vasoconstriction induced by phenylephrine. Chinese Pharmacological Bulletin. 2003;19(12):1358-61.3.

3. Patents:

Jiang Liping, et al. A hybrid contrast-assisted device for pulmonary arterial hypertension heart and its use method, Patent No.: 202211295886.8

Hong Tao, Wang Yang, Jiang Liping, et al. Use of 1-heptanol in the preparation of medicines for treating acute and chronic cerebral vasospasm, National Invention Patent, CN1486688A

4. Awards and Achievements:

"Mechanism of Gap Junction Involvement in Cerebral Vasospasm", Second Prize of Natural Science Award of the Ministry of Education (2006-105)

"Role of Gap Junction in Cerebral Vasospasm", Third Prize of Natural Science Award of Jiangxi Province (Z-106-04-3-05-R02)

"Study on the Effect of Specific Blockade of Gap Junction on Cerebral Vasospasm", Second Prize of Science and Technology Achievement Award of Jiangxi Universities and Colleges (J060204)

"Strengthening the Integration of Industry, Education, and Research to Serve the Local Economy and Assist Pharmaceutical Enterprises", Nanchang University Social Service Achievement Award, 2021

"Role and Mechanism of USP8 Stabilizing Cx43 Regulating Hemichannel Activity in Myocardial Ischemia-Reperfusion Injury", Excellent Paper Award at the 3rd National Postgraduate Academic Symposium on Pharmacy, Shenyang, July 2023, Corresponding Author