RESUME
Personal Information
Name: Kaiyun Chen
Date of Birth: February 1979
Political Affiliation: Member of the Communist Party of China
Major & Educational Background: Master of Pharmaceutical Analysis; Doctoral Candidate in Orthopedics (Academic Program), Xi'an Jiaotong University, Class of 2022
Position: Director of the Science and Education Department & Office of Drug Clinical Trial Institution
Honorary Title: The 7th “Young and Middle-aged Experts with Outstanding Contributions to Health in Jiangxi Province”
Professional Title & Certificates: Chief Pharmacist; Academic Master's Supervisor at the School of Pharmacy, Nanchang University; Licensed Pharmacist; Clinical Pharmacist; National Level-2 Psychological Counselor
Qualification Certificates: Certificate of Chief Pharmacist; Certificate of Licensed Pharmacist; Certificate of Clinical Pharmacist (issued by Jiangxi Provincial Health Commission); Certificate of National Level-2 Psychological Counselor; Certificate of Completion of the Pharmaceutical Administration Training Program of JICA (Japan International Cooperation Agency)
English Proficiency: CET-6; Obtained a qualification certificate by passing the official CITY AND GUIDES training of the JICA (Japan-funded further study program); Certificate of Passing the Advanced English Training Exam for National Government-sponsored Overseas Study; Simultaneous Interpreter at the 2015 Zijincheng Pharmaceutical Conference
Educational Background
Highest Education: Master's Degree
Institution for Highest Education: Jiangxi University of Chinese Medicine
Major: Pharmaceutical Analysis
Period: September 2005 - June 2008
Work Experience
★ September 2001 - April 2005: Quality Inspection Department and Drug Research Institute of Jiangxi Pharmaceutical Co., Ltd
★ July 2008 - March 2015: Pharmacy Department of the Fourth Affiliated Hospital of Nanchang University, engaged in clinical pharmacy, clinical pharmacist
★ March 2015 - Present: Director of the Office of Drug Clinical Trial Institution
★ February 2022 - Present: Director of the Science and Education Department & Office of Drug/Medical Device Clinical Trial Institution (covering the Discipline Office, Medical Ethics Office, Translational Engineering Research Institute, and Jiangxi Provincial Clinical Research Center)
Training Experience
★ April 2009 - April 2010: Received a one-year clinical pharmacist training in gastroenterology (sponsored by Jiangxi Provincial Health Commission) at the First Affiliated Hospital of Nanchang University and passed the assessment.
★ November 2014 - December 2014: Participated in a 28-day pharmaceutical administration training program organized by JICA (Japan International Cooperation Agency) in Tokyo and Toyama, Japan.
Research Projects & R&D Experience: Have successively presided over or participated in 11 scientific research projects at various levels, including 4 national-level projects, 3 provincial-level projects, 1 municipal-level key project, and 1 general project.
1．January 2025 - December 2028: Project Leader, National Natural Science Foundation of China (regional project), “Exploring the Mechanism of Traditional Chinese Medicine Gushiling Capsule in Regulating Hormone-Induced Lipoprotein Subfraction Metabolic Disorder to Prevent and Treat Osteonecrosis of the Femoral Head Based on PPAR-γ Regulating AMPK-Mediated Balance between Autophagy and Apoptosis”.Project No. 82460878, Approved Fund: ￥320,000 (Ongoing).
2．January 2024 - December 2025: Project Leader, Key Project of the Science and Technology Program of Jiangxi Provincial Administration of Traditional Chinese Medicine, “Study on the Intervention Effect and Mechanism of Traditional Chinese Medicine Gushiling Capsule on Glucocorticoid-Induced Osteocyte Apoptosis via the Mitochondrial Pathway”. Project No. 2023Z024, Approved Fund: ￥30,000 (Ongoing).
3．January 2021 - December 2024: Project Leader, National Natural Science Foundation of China (regional project), “Study on the Role of Lipoprotein Subfractions in Steroid-Induced Osteonecrosis of the Femoral Head and the Intervention Mechanism of Traditional Chinese Medicine”. Project No. 82060812, Approved Fund: ￥340,000 (Ongoing).
4．December 2021: Ranked 2nd, National Natural Science Foundation of China (General Program), “Study on the Mechanism of Traditional Chinese Medicine Gushiling Capsule in Preventing Steroid-Induced Osteonecrosis of the Femoral Head by Regulating Osteocyte Mitochondrial Cardiolipin Metabolism and Apoptotic Protein Release”. Project No. 82060812, Approved Fund: ￥550,000 (Ongoing).
5．June 2015: Project Leader, Social Development Project of Jiangxi Provincial Department of Science and Technology, “Preliminary Study on the Safe Window of Blood Drug Concentration for Glucocorticoid-Induced Osteonecrosis of the Femoral Head”, Project No. 20151BBG70202, Approved Fund: ￥30,000 (Completed).
6．June 2015: Project Leader, Natural Science Foundation Project of Jiangxi Provincial Department of Science and Technology, “Efficacy Evaluation and Mechanism Study of Different Lipid-Lowering Drugs in Preventing Hormone-Induced Osteonecrosis of the Femoral Head Based on Lipid Metabolomics Technology”. Project No. 20151BAB205054, Approved Fund: ￥50,000 (Completed).
7．December 2014: Project Leader, Science and Technology Project of Jiangxi Provincial Health Commission, “Effect of Ginsenoside Rg3 on Autophagy of Human Breast Cancer Cells”. Project No. 20155356 (Completed).
8．August 2014: Ranked 3rd, National Natural Science Foundation of China (General Program), “Study on the Mechanism of Gushiling Capsule in Intervening Hormone-Induced Osteonecrosis of the Femoral Head Based on Lipid Metabolomics Technology”. Project No. 81473707 (Completed).
9．July 2011: Ranked 2nd, Science and Technology Support Program Project of Jiangxi Province, “Monitoring of Blood Drug Concentration of Levetiracetam in Special Populations”. Project No. 20112BBG70074 (Completed).
10．October 2010: Project Leader, Scientific Research Fund Project of Nanchang University, “Study on the Method for Monitoring Blood Drug Concentration of the Antiepileptic Drug Lamotrigine Based on HPLC/MS/MS Technology” (Completed).
11．March 2009: Project Leader, Scientific and Technological Fund Project of the Hospital, “Study on Blood Drug Concentration Detection Method and Pharmacokinetics Based on HPLC/MS/MS Technology”. (Completed).
Published Works: Have successively published more than 20 papers, including 14 as the first author or corresponding author, 5 included in SCI, 6 published in core journals, and edited one monograph.
1. Kaiyun Chen, Xuhuan Li, Dan Chen, et al. PPARγ inhibitors enhance the efficacy of statin therapy for steroid-induced osteonecrosis of the femoral head by directly inhibiting apoptosis and indirectly modulating lipoprotein subfractions [J]. PLoS One, 2025, 20(6): e0325190.
2. Dan Chen, Duming Zhong, Runhong Mei, Shida Qian, Peng Wang, Kaiyun Chen and Xuefeng Yu. Screening and identification of potential key biomarkers for glucocorticoid-induced osteonecrosis of the femoral head. Journal of Orthopadic Surgery and Research, JAN 11 2023:18(1)；
3. Kai-Yun Chen, Jiang-Xia Xu, Meng-Meng Wang et al. Tianyu Zhong f,Single probe PCR melting curve analysis MTHER C677T SNP sites,Analytical biochemistry,15 April 2021:volume 619,114102；
4. Hanhong Zhang, Jing Gao, Mengmeng Wang, Xuefeng Yu, Xiuhua Lv, Huan Deng, Xiangwei Fan, Kaiyun Chen. Effects of scalp electroacupuncture on the PI3K/Akt signalling pathway and apoptosis of hippocampal neurons in a rat model of cerebral palsy.Acupuncture in Medicine 2017;0:1–7.doi:10.1136/acupmed-2016-011335
5. Zixuan WANG, Xiangwei FAN, Kaiyun CHEN, Xuefeng YU, Jing GAO. Effects of three kinds of head acupuncture therapies on regulation of brain microenvironment and rehabilitation of nerve function in rats with cerebral palsy, Jounal of Traditional Chinese Medicine,2021 April 15;
41(2): 276-283；
6. Xiangnan Ren1,3, Zixing Shao1 , Wu Fan2 , Zixuan Wang4 , Kaiyun Chen2* and Xuefeng Yu2* ，Untargeted metabolomics reveals the effect of lovastatin on steroid-induced necrosis of the femoral head in rabbits，Journal of Orthopaedic Surgery and Research (2020) 15:497；
7. Wu Fan, Xuefeng Yu, Xiangnan Ren, Kaiyun Chen. Intervention effect of traditional Chinese medicine Gushiling Capsule on early steroid-induced osteonecrosis of the femoral head in rabbits [J]. The Journal of Practical Medicine, 2018, 34(13): 2141-2145.
8. Kaiyun Chen, Xiuhua Lv, Zhen Liu, et al. Study on triglyceride metabolism in plasma of rabbits with hormone-induced osteonecrosis of the femoral head and the intervention effect of traditional Chinese medicine [J]. The Journal of Practical Medicine, 2017, 33(2): 206-209.
9. Kaiyun Chen, Jie He, Wenli Liang, et al. Effect of 20(R)-ginsenoside Rg3 on autophagy of human breast cancer cells [J]. Contemporary Medicine, 2016, 22(23): 1-3.
10. Kaiyun Chen, Xuefeng Yu, Zhen Liu, et al. Analysis of triglyceride metabolism after western medicine intervention in osteonecrosis of the femoral head based on metabolomics technology [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2016, 31(11): 4452-4455.
11. Yan Zhu, Kaiyun Chen *. Experimental study on different lipid-lowering drugs in preventing hormone-induced osteonecrosis of the femoral head [J]. Modern Diagnosis & Treatment, 2016, 27(20): 3876-3878.
12. Kaiyun Chen, et al. Experimental study on Gushiling Capsule in preventing steroid-induced osteonecrosis of the femoral head based on the TCM theory of “preventive treatment of disease” [J]. Chinese Journal of Traditional Chinese Medicine Science and Technology, 2014,
21(4): 369-371.
13. Xuefeng Yu*, Kaiyun Chen, et al. Exploration on the mechanism of Gushiling Capsule in intervening hormone-induced osteonecrosis of the femoral head based on metabolomics technology [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2014, 29(5): 317-320.
14. Kaiyun Chen, Liping Luo, et al. Simultaneous determination of lamotrigine and carbamazepine in human serum by high-performance liquid chromatography-tandem mass spectrometry [J]. Evaluation and Analysis of Drug-Use in Hospitals of China, 2012, 12(12): 1108-1110.
15. Kaiyun Chen, Huiqun Chen, et al. Pharmacokinetics and bioequivalence study of gliclazide sustained-release tablets in humans [J]. China Pharmacy, 2010, 21(46): 4364-4366.
16. Kaiyun Chen, Wenyi Xie. Comparison of Short-Term Adverse Reactions Between Combination Chemotherapy and Sequential Chemotherapy with Docetaxel, Epirubicin, and Cyclophosphamide [J]. Journal of Medical Information, 2013(11): 1-3.
17. Kaiyun Chen, Wuliang Yang, Qianfeng Gong, et al. Study on the enrichment process of total flavonoids from cirsium japonicum using macroporous adsorption resins [J]. SHIZHEN Medicine and Materia Medica Research, 2007(10): 2356-2357.
18. Kaiyun Chen, Xiaoquan Luo, Wuliang Yang, et al. Research progress of traditional Chinese medicine Cirsium japonicum DC. [J]. Journal of Jiangxi University of Traditional Chinese Medicine, 2007(4): 94-96.
19. Wu Fan, Xuefeng Yu, Xiangnan Ren, Kaiyun Chen, et al. Intervention effect of traditional Chinese medicine Gushiling Capsule on early steroid-induced osteonecrosis of the femoral head in rabbits [J]. The Journal of Practical Medicine, 2021, 34(13): 2141-2145.
20. Xiangnan Ren, Wu Fan, Zixing Shao, Kaiyun Chen, Xuefeng Yu, Qionglin Liang. A metabolomic study on early detection of steroid-induced avascular necrosis of the femoral head,Oncotarget,2018,9(8):7984-7995；
21. Editor-in-Chief, Practical 500 Questions on the Management of Drug and Medical Device Clinical Trials, Jiangxi Science and Technology Press, November 2023, 170,000 words.
Academic Societies & Social Part-time Positions
Member of the 2nd Jiangxi Provincial Medical Ethics Expert Committee (established by Jiangxi Provincial Health Commission, with 15 members in the province)
Member of the 6th Medical Appraisal Expert Database of Jiangxi Medical Association
Expert and Team Leader of the Daily Inspection Group for Drug Clinical Trials, Jiangxi Provincial Drug Administration
Expert and Team Leader of the Drug Registration and Evaluation Expert Database, Jiangxi Provincial Drug Administration
Expert and Team Leader of the Inspection Expert Database of Jiangxi Medical Device Evaluation Center
External Expert of the Medical Ethics Committee of Jiangxi Maternal and Child Health Hospital
Director of the 2nd Council of Jiangxi Society for Clinical Trial and Research of Drugs
Standing Member of the 1st Medical Device Professional Committee of Jiangxi Society for Clinical Trial and Research of Drugs
Member of the 2nd Committee of the Hospital Information and Library Management Professional Committee of Jiangxi Hospital Association
Standing Member of the 1st CRC Management Professional Committee of JiangxiSociety for Clinical Trial and Research of Drugs
Standing Member of Jiangxi Translational Medicine Society
Member of Jiangxi Provincial Science and Technology Expert Database
Member of Hunan Provincial Science and Technology Expert Database
Member of Yunnan Provincial Science and Technology Expert Database
Member of Heilongjiang Provincial Science and Technology Expert Database
Honors:2024: Awarded the title of the 7th “Young and Middle-aged Experts with Outstanding Contributions to Health in Jiangxi Province”
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