Personal Profile
Qi Wang, female, Distinguished Researcher, Doctoral Supervisor, Member of the Communist Party of China. She obtained her Bachelor of Science degree in Biological Science from Qingdao Agricultural University in 2011, and her Doctor of Philosophy degree in Medicinal Chemistry from Ocean University of China in 2016 (integrated master's and doctoral program). She was awarded the National Scholarship for Doctoral Students in 2015. She joined Qingdao University in 2016 and completed her postdoctoral training at Hefei Institutes of Physical Science, Chinese Academy of Sciences from 2017 to 2018. She was appointed Associate Professor of Qingdao University in January 2024 and joined Nanchang University as a Distinguished Researcher (high-level talent) in October 2025. Since her master's and doctoral studies, she has been engaged in research related to marine natural medicinal chemistry. Currently, she has published 14 series of research papers as first author/corresponding author (including co-first author and co-corresponding author) in authoritative journals in the field such as Organic Letters, Journal of Natural Products and The Journal of Organic Chemistry. She has applied for 3 national invention patents, presided over General Program and Youth Program of the National Natural Science Foundation of China, and participated in the Young Scientists Project of the National Key Research and Development Program of the Ministry of Science and Technology as a sub-project leader.
Research Directions
Efficient discovery of new structures of characteristic alkaloids from Xisha sponges guided by UV tracking；Construction of high-throughput screening models for biological activities suitable for marine small molecules and in-depth mining of marine drug lead compounds；Biosynthesis research of sponge-derived characteristic alkaloid families indicated by crude enzyme reaction.
Representative Papers in the Past Five Years
1. Peng, D.; Luo, X. C.; Zhu, R. W.; Tong, W. L.; Yang, Y. N.; Li, G. Q.; Wang, Q.* Tagpyrrollins A and B and Tagpyrrollidone A: Three Pyrrole Steroid Analogues with AKR1B1-Targeting Inhibitory Activity from the Sponges Stylissa massa and Pseudospongosorites suberitoides. Organic Letters, 2024, 26, 5794-5798.
2. Liu, X. J.†; Wang, Q.†; Zhang, Y.*; Zhang, H. T.* Discovery of Anti-Inflammatory Alkaloids from Sponge Stylissa massa Suggests New Biosynthetic Pathways for Pyrrole–Imidazole Alkaloids. Marine Drugs, 2024, 22, 477.
3. Wang, Q.; Gao, C. H.; Wei, Z.; Tang, X. W.; Ji, L. X.; Luo, X. C.; Peng, X. P.; Li, G.; Lou, H. X.* A Series of New Pyrrole Alkaloids with ALR2 Inhibitory Activities from the Sponge Stylissa massa. Marine Drugs, 2022, 20, 454.
4. Cheng, M. M.; Cui, X. C.; Tang, Y.; Shao, Z. Z.; Liu, X. P.; Su, J. C.; Zhang, J.; Wang, Q.*; Li, G. Q.* Total Synthesis of Leptochartamides A and B: Two Enantiomeric Pairs of Hydroxybenzyl Dimers from a Deep-Sea Fungus Leptosphaerulina chartarum. The Journal of Organic Chemistry, 2022, 87, 11090-11096.
5. Han, X.†; Wang, Q.†,*; Luo, X. C.; Tang, X. L.; Wang, Z.; Zhang, D.; Cao, S. G.; Li, P. L.*; Li, G. Q.* Lemnalemnanes A−C, Three Rare Rearranged Sesquiterpenoids from the Soft Corals Paralemnalia thyrsoides and Lemnalia sp. Organic Letters, 2022, 24, 11-15.
6. Cheng, M. M.; Li, P. L.*; Jiang, Y.; Tang, X. L.; Zhang, W. J.; Wang, Q.*; Li, G. Q.* Penitol A and Penicitols E−I: Citrinin Derivatives from Penicillium citrinum and the Structure Revision of Previously Proposed Analogues. Journal of Natural Products, 2021, 84, 1345-1352.
7. Luo, X. C.†; Wang, Q.†,*; Tang, X. L.; Xu, J. X.; Wang, M. X.; Li, P. L.*; Li, G. Q.* One cytotoxic steroid and other two new metabolites from the South China Sea sponge Luffariella variabilis. Tetrahedron Lett., 2021, 65, 152762.
8. Luo, X. C.†; Wang, Q.†; Tang, X. L.; Li, P. L.*; Li, G. Q.* Cytotoxic Manoalide-Type Sesterterpenes from the Sponge Luffariella variabilis Collected in the South China Sea. Journal of Natural Products, 2021, 84, 61-70.
9. Liu, M. Y.; Li, P. L.*; Tang, X. L.; Luo, X. C.; Liu, K. C.; Zhang, Y.; Wang, Q.*; Li, G. Q.* Lemnardosinanes A-I: New Bioactive Sesquiterpenoids from Soft Coral Lemnalia sp. The Journal of Organic Chemistry, 2021, 86, 970-979.
10. Wang, Q.; Sun, Y. T.; Yang, L.; Luo, X. C.; Voogd, N. J. D.; Tang, X. L.; Li, P. L.*; Li, G. Q.* Bishomoscalarane Sesterterpenoids from the Sponge Dysidea granulosa Collected in the South China Sea. Journal of Natural Products, 2020, 83, 516-523.
11. Wang, Q.; Tang, X. L.; Liu, H.; Luo, X. C.; Sung, P. J.; Li, P. L.*; Li, G. Q.* Clavukoellians G–K, New Nardosinane and Aristolane Sesquiterpenoids with Angiogenesis Promoting Activity from the Marine Soft Coral Lemnalia sp. Marine Drugs, 2020, 18, 171.
12. Wang, Q.; Hu, Z. Q.; Luo, X. C.; Liu, J.; Li, G. Q.*; Cao, S. G.*; Liu, Q. S.* Clavukoellians A−F, Highly Rearranged Nardosinane Sesquiterpenoids with Antiangiogenic Activity from Clavularia koellikeri. Journal of Natural Products, 2019, 82, 1331-1337.
13. Wang, Q.; Hu, Z. Q.; Li, X. X.; Wang, A. L.; Wu, H.; Liu, J.; Cao, S. G.*; Liu, Q. S.* Salviachinensines A−F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis. Journal of Natural Products, 2018, 81, 2531-2538.
14. Wang, Q.; Tang, X. L.; Luo, X. C.; Voogd, N. J. D.; Li, P. L.*; Li, G. Q.* (+)- and (−)-Spiroreticulatine, A Pair of Unusual Spiro Bisheterocyclic Quinoline-imidazole Alkaloids from the South China Sea Sponge Fascaplysinopsis reticulata. Organic Letters, 2015, 17, 3458-3461.
Hosted research projects
1. General Program of the National Natural Science Foundation of China, Project Title: Efficient Discovery and Mechanism Study of Alkaloid Components Targeting Aldose Reductase ALR2 from Sponge Stylissa massa, Principal Investigator: Wang Qi, 2023-2026 (520,000 RMB)
2. Youth Program of the National Natural Science Foundation of China, Project Title: Discovery of Antiangiogenic Nardosinane-Type Sesquiterpenoids from Two Species of Soft Corals in the Xisha Islands, Principal Investigator: Wang Qi, 2020-2022 (250,000 RMB)
3. Sub-project of the Young Scientists Project of the National Key Research and Development Program of the Ministry of Science and Technology, Project Title: Research on Efficient Discovery and In-depth Mining Technology of Deep-Sea Heteroatom-Containing Lead Compounds, Sub-project Leader: Wang Qi, 2022-2025 (600,000 RMB)
Scientific Research Awards
Scientific Research Awards
1. Marine Science and Technology Award of the Chinese Society for Oceanography (Provincial and Ministerial Second Class, 3rd place.
2. National Scholarship for Doctoral Students, 2015
Patents：
1. Wang Qi; Liu Xiaojing; Zhang Hanting; A Sponge-Derived Alkaloid Tetramer and Its Efficient Preparation Method and Application, 202410507712.6
2. Wang Qi; Zhu Runwei; Peng Di; Han Mei; A Preparation Method and Application of a Class of Sponge-Derived Pyrrole-Imidazole Alkaloids，202511201486X
3. Zhang Hanting; Gao Chunhua; Wang Qi; Wang Zhe; Dong Mingxin; Liu Xiaojing; A high-throughput screening method for phosphodiesterase inhibitors, CN202311146827.9
Cn
