Xuan Huang,Researcher

Nationality

China

Ethnicity

Han

Native Place

Nanchang, Jiangxi Province

Professional Title

Researcher

Position

None

Supervisor Type

Doctoral Supervisor

Email

huangxuan@ncu.edu.cn

Courses Taught

Progress in Translational Medicine Research、Common Experimental Techniques and Methods in Translational Medicine Research

Research Interest

Screening and mechanism research of targets in the tumor immune microenvironment; Screening of anti-tumor monoclonal antibody drugs;

Regulatory mechanism research of key signaling pathways in tumors

Educational Background

2000.9~2004.6: Hefei University of Technology, Biological Engineering, Bachelor of Engineering

2005.9~2010.6: Wuhan University, Microbiology, Doctor of Science

Work Experience

2010.7~2012.6: Postdoctoral Fellow, Clinical Medicine Postdoctoral Mobile Station, The First Affiliated Hospital of Nanchang University

2012.7~2015.11: Assistant Researcher (University-appointed Associate Professor), Institute of Translational Medicine, Nanchang University

2015.12~2022.11: Associate Researcher, Institute of Translational Medicine, Nanchang University

2016.9~2018.9: Visiting Scholar, School of Medicine, University of Missouri-Kansas City, USA

2022.12~Present: Researcher, Institute of Translational Medicine, Nanchang University

Academic Appointments

² Peer Review Expert, National Natural Science Foundation of China (NSFC)

² Project Review Expert for Provincial Science and Technology Programs (Jiangxi Province & Hebei Province)

Personal Honors

² 2015: Ganjiang Young Scholar of the First Batch of "215 Talent Project" of Nanchang University

² 2022: Recipient of Jiangxi Provincial Talent Program

Major Achievements

Main Scientific Research Achievements

Has successively led 6 national-level Natural Science Foundation projects (3 completed) and 3 provincial Natural Science Foundation projects. Holds 4 authorized national invention patents. Has published over 20 academic papers in authoritative domestic and international journals, with more than 20 as first author or corresponding author (including 7 SCI papers classified as Q1 in the Chinese Academy of Sciences journal partition). The cumulative citation count of these papers exceeds 800.

1. Hosted Research Projects

[1] 2026.1-2029.12: National Natural Science Foundation of China (NSFC) Regional Program, "The role and mechanism of the FBXO25/SPOP/Gli2 positive feedback loop in the pathogenesis and progression of clear cell renal cell carcinoma" (No. 82560587), RMB 320,000, Principal Investigator

[2] 2024.7-2027.6: Chongqing Natural Science Foundation General Program, "Mechanism of TRIM65 in promoting renal cell carcinoma proliferation and development of targeted polypeptide drugs" (No. CSTB2024NSCQ-MSX0528), RMB 100,000, Principal Investigator

[3] 2022.1-2025.12: National Natural Science Foundation of China (NSFC) General Program, "The role and mechanism of TRIM65 knockout in promoting M2 polarization of tumor-associated macrophages in lung cancer" (No. 32170793), RMB 580,000, Principal Investigator

[4] 2023.1-2025.12: Jiangxi Provincial Natural Science Foundation Distinguished Young Scholar Program, "Mechanism of E3 ubiquitin ligase TRIM47 in promoting the pathogenesis and progression of hepatocellular carcinoma" (No. 20224ACB216013), RMB 200,000, Principal Investigator

[5] 2020.1-2023.12: National Natural Science Foundation of China (NSFC) Regional Program, "The role and mechanism of TRIM65 in acute lung injury" (No. 31960147), RMB 390,000, Principal Investigator, Completed

[6] 2017.1-2020.12: National Natural Science Foundation of China (NSFC) Regional Program, "The role and mechanism of TRIM14 in the pathogenesis and progression of non-small cell lung cancer" (No. 81660390), RMB 380,000, Principal Investigator, Completed

[7] 2014.1-2016.12: National Natural Science Foundation of China (NSFC) Youth Program, "Screening and application of anti-tumor polypeptide drugs based on S-phase kinase-associated protein 2" (No. 81301964), RMB 230,000, Principal Investigator, Completed

2. Representative Publications

1. Jinping Nie^#, Chao Mei^#, Aiping Wei, Yingjie Wang, Chenlu Fan, Yingjie Huang, Ming Jiang, Han Che, Tao Chen, Juan Tian, Yong Li*, Xuan Huang*, Xuekang Zhang*, TRIM2 inhibits apoptosis by ubiquitinating BNIP3 to protect the intestine against ischemia-reperfusion injury in mice, Communications Biology, 8(1):1308, 2025.

2. Tao Chen^#, Yang Zhang^#, Liting Ding, Chenlu Xiong, Chao Mei, Sisi Wei, Ming Jiang, Yingjie Huang, Jianrong Chen, Tao Xie, Qing Zhu, Qi Zhang, Xuan Huang*, Shibiao Chen*, Yong Li*, Tripartite motif containing 65 deficiency confers protection against acute kidney injury via alleviating voltage-dependent anion channel 1-mediated mitochondrial dysfunction, MedComm, 6(6):e70149, 2025.

3. Sisi Wei^#, Xuan Huang^#, Qing Zhu, Tao Chen, Yan Zhang, Juan Tian, Tingyu Pan, Lv Zhang, Tao Xie, Qi Zhang, Xian Kuang, Enjun Lei, Yong Li*, TRIM65 deficiency alleviates renal fibrosis through NUDT21-mediated alternative polyadenylation, Cell Death and Differentiation, 31(11):1422-1438, 2024.

4. Qi Zhang^#, Yong Li^#, Qing Zhu, Tao Xie, Yue Xiao, Feng Zhang, Na Li, Keyu Deng, Hongbo Xin, Xuan Huang*, TRIM65 promotes renal cell carcinoma through ubiquitination and degradation of BTG3, Cell Death and Disease, 15:355, 2024.

5. Yingjie Huang, Tao Chen, Ming Jiang, Chenlu Xiong, Chao Mei, Jinping Nie, Qi Zhang, Qing Zhu, Xuan Huang*, Xuekang Zhang*, Yong Li*, E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis, Cell Death and Disease, 15:29, 2024.

6. Shuzhou Deng, Le Ding, Yisong Qian, Xuan Huang*, The role of ubiquitin-proteasome system (UPS) in asthma pathology, Journal of Asthma and Allergy, 18:307-330, 2025.

7. Wangxi Wu^#, Jinyu Yang^#, Tian Yu, Zhuoling Zou, Xuan Huang*, The role and mechanism of TRIM proteins in gastric cancer, Cells, 13(24):2107, 2024.

8. Kangning Li, Tao Xie, Yong Li, Xuan Huang*, LncRNAs act as modulators of macrophages within the tumor microenviroment, Carcinogenesis, 45(6):363-377, 2024.

9. Yue Xiao, Ruiqian Liu, Na Li, Yong Li, Xuan Huang*, Role of the ubiquitin-proteasome system on macrophages in the tumor microenvironment, Journal of Cellular Physiology, 239(2):e31180, 2024.

10. Sisi Wei^#, Meiling Ai^#, Yuan Zhan, Jieqing Yu, Tao Xie, Qinghua Hu, Yang Fang, Xuan Huang*, Yong Li*, TRIM14 suppressed the progression of NSCLC via hexosamine biosynthesis pathway, Carcinogenesis, 45(5):324-336, 2024.

11. Lei Zhou, Qi Zhang, Qing Zhu, Yuan Zhan, Yong Li*, Xuan Huang*, Role and therapeutic targeting of glutamine metabolism in non-small cell lung cancer, Oncology Letters, 25:159, 2023.

12. Yong Li, Qi Zhang, Na Li, Liting Ding, Jinping Yi, Yue Xiao, Shibiao Chen, Xuan Huang*, Ataxin-10 inhibits TNF-α-induced endothelial inflammation via suppressing interferon regulatory factor-1, Mediators of Inflammation, 2021: 7042148, 2021.

13. Yingjie Huang, Yue Xiao, Xuekang Zhang*, Xuan Huang*, Yong Li*, The emerging roles of tripartite motif proteins (TRIMs) in acute lung injury, Journal of Immunology Research, 2021:1007126, 2021.

14. Liting Ding^#, Yang Fang^#, Yong Li, Qinghua Hu, Meiling Ai, Keyu Deng, Xuan Huang*, Hongbo Xin*, AIMP3 inhibits cell growth and metastasis of lung adenocarcinoma through activating a miR-96-5p-AIMP3-p53 axis, Journal of Cellular and Molecular Medicine, 25(6): 3019-3030, 2021.

15. Xuan Huang, Yong Li, Daping Fan, Hongbo Xin*, Mingui Fu*, TRIM14 promotes endothelial activation via activating NF-κB signaling pathway, Journal of Molecular Cell Biology,12(3): 176-189, 2020.

16. Xuan Huang, Yong Li, Mingui Fu, Hongbo Xin*, Polarizing macrophages in vitro, Methods in Molecular Biology, 1784: 119-126, 2018.

17. Yong Li^#, Xuan Huang^#, Shengping Huang^#, Hui He, Tianhua Lei, Fatma Saaoud, Xiaoqiang Yu, Ari Melnick, Anil Kumar, Christopher J Papasian, Daping Fan, Mingui Fu*, Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury, Signal Transduction and Targeted Therapy, 2: e17066, 2017. (#Co-first authors)

18. Xuan Huang, Mingjie Huang, Lingbao Kong, YongLi*, miR-372 suppresses tumour proliferation and invasion by targeting IGF2BP1 in renal cell carcinoma, Cell Proliferation, 48: 593-599, 2015.

19. Wei Wang^#, Xuan Huang^#, Hong-Bo Xin, Mingui Fu, Aimin Xue, Zhao-Hui Wu*, TRAF family member-associated NF-κB activator(TANK) inhibits genotoxic nuclear factor κB activation by facilitating deubiquitinase USP10-dependent deubiquitination of TRAF6 ligase, Journal of Biological Chemistry, 290(21): 13372-13385, 2015.(#Co-first authors)

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