Recently, the research group led by Xiao-Dong Xiong at the School of Pharmacy, Nanchang University published a research paper entitled “Enantioselective Synthesis of Chiral Sulfinamidines via Asymmetric Amination of Sulfenamides Using a Chiral Phosphoric Acid Catalyst” in Angewandte Chemie International Edition (IF=16.9, CAS Top Journal, Q1).
We disclosed a chiral phosphoric acid-catalyzed asymmetric strategy for the synthesis of chiral sulfinamidines through the direct amination of sulfenamides. This method demonstrated remarkable substrate scope and excellent yields and stereoselectivities across a diverse array of sulfinamidine compounds. The synthetic utility and practicability of this robust protocol were further highlighted through gram scale reactions, product derivatization and late-stage functionalization of natural products and drugs.
Qi Chen (2023 Master’s student) and Chaoxiang Ning (2025 Ph.D. candidate) from the School of Pharmacy, Nanchang University are the co-first authors, and Professor Xiao-Dong Xiong is the corresponding author.
Article link：Enantioselective Synthesis of Chiral Sulfinamidines via Asymmetric Amination of Sulfenamides Using a Chiral Phosphoric Acid Catalyst - Chen - 2026 - Angewandte Chemie International Edition - Wiley Online Library
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