仿生纳米药物载体；血浆脂蛋白和脂质代谢（重点疾病：动脉粥样硬化）；药剂学/药理学；细胞生物学；生物荧光探针等

2000.9-2003.6：中科院安光所/暨南大学化学系联合培养（光学博士）

1997.9-2000.6：暨南大学生物工程学系（生物学硕士）

1993.9-1997.6：南昌大学生物系（生物学学士）

2024.7-至今：南昌大学药学院（研究员）

2017.12-2019.1：美国纽约州立大学下州医学院细胞生物学系（访问学者）

2013.12-2024.7：南昌大学高等研究院（研究员）

2009.3-2013.12：南昌大学高等研究院（高层次引进人才/特聘教授）

2008.4-2009.3：美国伊利诺伊大学非人灵长类生物医学研究中心（研究助理教授）

2004.9-2008.4：美国伊利诺伊大学微生物与免疫系（博士后）

2003.7-2004.9：暨南大学生命学院化学系（助教、讲师）

（1） 国际评审专家：欧洲研究委员会（European Research Council）科研项目二审；匈牙利NKFIH（国家研究、发展和创新署）科研项目。

（2） 国内评审或督导专家：国家自然科学基金委、江西及其他若干省份的科技项目评审专家；江西省科技项目督导组专家；教育部硕士/博士学位论文评审专家。

（3） 学术期刊编委：<Pharmaceutics>、<BMC Molecular and Cell Biology>、<Mini-Reviews in Medicinal Chemistry>、<Current Drug Delivery> (Section Editor)、<Experimental and Therapeutic Medicine>等SCI期刊的编委；<Pharmaceutical Biology>、<International Journal of Molecular Sciences>、<Frontiers in Pharmacology>等SCI期刊的客座顾问/编辑/主编；<Cardiovascular Innovations and Applications>、<AIMS Medical Science>等ESCI期刊的编委；<Sumerianz Journal of Biotechnology>副主编。

（4）学会/协会/专委会理事或委员：白求恩精神研究会医学人文分会常务理事、临床医学学组专委会常委；中国老年保健协会气象医养健康专业委员会委员等。

（5）特邀审稿专家：<Advanced Functional Materials>、<Advanced Science>、<Cell Research>、<Small>、<Biomaterials>、<Carbohydrate Polymers>、<Journal of Nanobiotechnology>、<EMBO Molecular Medicine>、<Chemical Engineering Journal>、<Journal of Advanced Research>等100多个国际性权威学术期刊。

先后主持包括6项国家自然科学基金项目在内的科研项目20多项，参与科研项目十多项；发表中、英文论文一百多篇，其中英文SCI论文90多篇；获授权国家发明专利4项；主编英文专著1部；指导本科生大创项目和科研训练项目及研究生创新项目10余项。

主持的在研项目：

[1] 纳米尺度上原位探究聚集态低密度脂蛋白的形成机制，国家自然科学基金, 2025.1-2028.12。

[2] 脂质代谢关键分子在动脉粥样硬化发生发展中的作用及机制, 江西省科协项目。

2020年至今发表的SCI学术论文：

1) Kun Wang, Chenhan Sun, Hongda Zhuang, Xian-Cheng Jiang, Yong Chen*. AFM reveals differential effects of acidification on LDL- and oxidized LDL-receptor interactions: Biomechanical Implications in atherogenesis. Cellular & Molecular Biology Letters. 2025. 30: 32

2) Mengyi Lan, Yuan Zhang, Yong Chen*, Solving the contamination conundrum derived from coisolation of extracellular vesicles and lipoproteins: Approaches for isolation and characterization. Small Methods. 2025. 9: e01606

3) Yuan Zhang, Wendiao Zhang, Zhiwen Wu, Yong Chen*. Diversity of extracellular vesicle sources in atherosclerosis: Role and therapeutic application. Angiogenesis. 2025. 28: 34

4) Chenhan Sun, Qinghua Sheng, Ying Qin, Yong Chen*. Single-aggregate morphological and biomechanical detection of atherogenic aggregated low-density lipoprotein (agLDL) by atomic force microscopy. Colloids and Surfaces B: Biointerfaces. 2025. 254: 114864

5) Yuanfang Li^#, Yuan Zhang^#, Mengyi Lan, Zhilu Fan, Tingting Gong, Langtao Xu, Tong Rong, Kun Wang, Huaying Wang, Meiying Ao, Yong Chen*. Anti-atherosclerotic effect of lipid/cholesterol-cyclodextin inclusion complexes similar to free cyclodextrin in ApoE-/- mice fed a high-fat diet. Carbohydrate Polymer Technologies and Applications. 2025. 10: 100811

6) Haonan Zhao#, Zhendong Huang#, Qinghua Sheng, Wenxiang Shao, Min Zeng, Kun Wang, Yang Zhang, Ying Qin, Zhihao Xiong, Lizhen Chen, Huaying Wang, Tong Rong, Zhitao Qiu, Hongda Zhuang, Zhiwen Wu, Yuan Zhang, Wendiao Zhang*, Yong Chen*. Enhanced anti-tumour efficacy of iRGD-modified cell-bound membrane vesicles (iRGD-CBMVs) as a novel drug carrier. Journal of Extracellular Biology. 2025. 4: e70052

7) Lang W^#, Wu Z^#, Li J^#, Chen Y*, Cao Q*. A novel coumarin-linked tetraphenylethene fluorescent probe for simultaneous sensing of ATP and GSH. Sensors and Actuators: B. Chemical. 2024. 412: 135772

8) Wu J, Li J, Shao W, Hu Y, Chen H, Chen Y, Chen Y, Liu Q, Ao M*. Cyclodextrins as therapeutic drugs for treating lipid metabolism disorders. Obesity Reviews. 2024. 25(4): e13687

9) Sun C, Qin Y, Zhuang H, Zhang Y, Wu Z, Chen Y*. Membrane vesicles as drug delivery systems: Source, preparation, modification, drug loading, in vivo administration and biodistribution, and application in various diseases. Pharmaceutics. 2023. 15(7): 1903

10) Lang W^#, Chen L^#, Chen Y*, Cao Q*. A GSH-activated AIE-based polymer photosensitizer for killing cancer cells. Talanta. 2023. 258: 124473

11) Wang K^#, Li Z., Egini O., Wadgaonkar R., Jiang X*, Chen Y^#,*. Atomic force microscopy reveals involvement of the cell envelope in biomechanical properties of sickle erythrocytes. BMC Biology. 2023. 21: 31

12) Min Gao, Le Zeng, Linhan Jiang, Mingyu Zhang, Yong Chen*, Ling Huang*. Bodipy dimer for enhancing triplet-triplet annihilation upconversion performance. Molecules. 2023. 28(14): 5474

13) Zhou Y^#, Qin Y^#, Sun C., Liu K., Zhang W., Gaman M.A., Chen Y*. Cell-bound membrane vesicles contain antioxidative proteins and probably have an antioxidative function in cells or a therapeutic potential. Journal of Drug Delivery Science and Technology. 2023. 81: 104240

14) Qin Y^#, Zhou Y^#, Wang K., Gu J., Xiong Z., Zhang W., Chen Y*. In situ isolation of nuclei or nuclear proteins from adherent cells: A simple, effective method with less cytoplasmic contamination. Biological Research. 2023. 56: 18

15) Bai H^#, Xiong Z^#, Zhou F^#, Qin J., Wen S., Li Z*, Chen Y*, Cao Q*. An amphiphilic tetraphenylethylene-based photosensitizer for cancer cell ablation and bacteria killing. Dyes and Pigments. 2022. 206: 110652.

16) Wei B., Li Y., Ao M., Shao W., Wang K., Rong T., Zhou Y., Chen Y*. Ganglisoide GM3-functionalized reconstituted high-density lipoprotein (GM3-rHDL) as a novel nanocarrier enhances antiatherosclerotic efficacy of statins in apoE^-/- C57BL/6 mice. Pharmaceutics. 2022. 14(11): 2534

17) Li Y^#, Zhou J^#, Gu J, Shao Q, Chen Y*. Enhanced antibacterial activity of levofloxacin/hydroxypropyl-b-cyclodextrin inclusion complex: In vitro and in vivo evaluation. Colloids and Surfaces B: Biointerfaces. 2022. 215: 112514.

18) Lang W^#, Zhou F^#, Chen Y*, Cao Q*. A new poly(norbornene)-based sensor for fluorescent ratiometric sensing of adenosine 5’-triphosphate. Dyes and Pigments. 2022. 200: 110187.

19) Li X^#, Wang H^#, Zhang Y, Cao Q*, Chen Y*. A GSH-responsive PET-based fluorescent probe for cancer cells imaging. Chinese Chemical Letters. 2021. 32(4): 1541-1544

20) Wang K, Gan C, Wang H, Ao M, Fan Y, Chen Y*. AFM detects the effects of acidic condition on the size and biomechanical properties of native/oxidized low-density lipoprotein. Colloids and Surfaces B: Biointerfaces. 2021. 208: 112053 (cover paper).

21) Rong T, Wei B, Ao M, Zhao H, Li Y, Zhang Y, Qin Y, Zhou J, Zhou F, Chen Y*. Enhanced anti-atherosclerotic efficacy of pH-responsively releasable ganglioside GM3 delivered by reconstituted high-density lipoprotein. International Journal of Molecular Sciences. 2021. 22(24): 13624.

22) Chen G^#, Zhou Y^#, Zhang W, Wei B, Sun Y, Chen Y*. Methyl-b-cyclodextrin suppresses the monocyte-endothelial adhesion triggered by lipopolysaccharide or oxidized low-density lipoprotein. Pharmaceutical Biology. 2021. 59(1): 1036-1044.

23) Wang K^#, Qin Y^#, Chen Y*. In situ AFM detection of the stiffness of the in situ exposed cell nucleus. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research. 2021. 1868(5): 118985.

24) Li Z^#, Chiang Y^#, He M, Zhang K, Zheng J, Wu W, Cai J, Chen Y, Chen G, Chen Y, Dong J, Worgall TS, Jiang XC*. Effect of liver total sphingomyelin synthase deficiency on plasma lipid metabolism. BBA – Molecular and Cell Biology of Lipids. 2021. 1866 (5): 158898

25) Wang K, Li Y, Luo C, Chen Y*. Dynamic AFM detection of the oxidation-induced changes in size, stiffness, and stickiness of low-density lipoprotein. Journal of Nanobiotechnology. 2020. 18: 167

26) Zhang W^#, Gu J^#,*, Li Y, Shan W, Xu Y, Chen Y^*. Single-vesicle tracking reveals the potential correlation of the movement of cell-bound membrane vesicles (CBMVs) with cell migration. BBA-Molecular Cell Research. 2020.1867 (11): 118804

27) Zhang Y, Liu Y, Zhang W, Tang Q, Zhou Y, Li Y, Rong T, Wang H, Chen Y^*. Isolated cell-bound membrane vesicles (CBMVs) as a novel class of drug nanocarriers. Journal of Nanobiotechnology. 2020. 18(1): 69

28) Guo Q#, Zhang Y#, Lin Z, Cao Q*, Chen Y*. Fluorescent norbornene for sequential detection of mercury and biothiols. Dyes and Pigments. 2020. 172: 107872 (a highly cited paper in 2020)

29) Cheng TH, Puskarich M, Li X, Fang Z, Xu F, Chen Y, Jiang XC, Worah S, Jones AE, Zhang M*. Circulating complement C3-alpha chain levels predict survival of septic shock patients. Shock. 2020. 54(2):190-197