肿瘤免疫微环境靶点的筛选及机制研究；抗肿瘤单抗药物筛选；肿瘤关键信号通路的调控机制研究

2000.9~2004.6：合肥工业大学，生物工程专业，工学学士

2005.9~2010.6：武汉大学，微生物学专业，理学博士

2010.7~2012.6：南昌大学第一附属医院，临床医学流动站，博士后

2012.7~2015.11：南昌大学转化医学研究院，助理研究员（校聘副教授）

2015.12~2022.11：南昌大学转化医学研究院，副研究员

2016.9~2018. 9：美国密苏里大学堪萨斯分校医学院，访问交流

2022.12~至今：南昌大学转化医学研究院，研究员

国家自然科学基金函评专家

江西省、河北省科技项目评审专家

2015年获得南昌大学首批“215人才工程”赣江青年学者

主要科研成果

先后主持国家级自然科学基金课题6项（完成3项），主持省自然科学基金项目等3项，授权国家发明专利4项。在国内外权威刊物发表学术论文二十余篇，其中第一作者或通讯作者二十余篇（中科院期刊分区为一区SCI论文7篇），累计论文引用次数超过800次。

1、 主持科研课题

[1] 2026.1-2029.12：国家自然科学基金地区基金项目“FBXO25/SPOP/Gli2正反馈环路在肾透明细胞癌发生发展中的作用及机制”（82560587），32万，主持

[2] 2024.7-2027.6：重庆市自然科学基金面上项目“TRIM65促进肾癌细胞增殖的机制研究及靶向多肽药物研发”（CSTB2024NSCQ-MSX0528），10万，主持

[3] 2022.1-2025.12：国家自然科学基金面上项目“TRIM65基因敲除促进肿瘤相关巨噬细胞M2型极化在肺癌中的作用及机制”（32170793），58万，主持

[4] 2023.1-2025.12：江西省自然科学基金杰出青年基金项目“E3泛素连接酶TRIM47促进肝细胞癌发生发展的机制研究”（20224ACB216013），20万，主持

[5] 2020.1-2023.12：国家自然科学基金地区基金项目“TRIM65在急性肺损伤中的作用及其机制研究”（31960147），39万，主持，已结题

[6] 2017.1-2020.12：国家自然科学基金地区基金项目“TRIM14在非小细胞肺癌发生发展中的作用及机制”（81660390），38万，主持，已结题

[7] 2014.1-2016.12：国家自然科学基金青年基金项目“基于S期激酶相关蛋白2的抗肿瘤多肽药物筛选与应用”（81301964），23万，主持，已结题

2、发表代表性论文

1. Jinping Nie#, Chao Mei#, Aiping Wei, Yingjie Wang, Chenlu Fan, Yingjie Huang, Ming Jiang, Han Che, Tao Chen, Juan Tian, Yong Li*, Xuan Huang*, Xuekang Zhang*, TRIM2 inhibits apoptosis by ubiquitinating BNIP3 to protect the intestine against ischemia-reperfusion injury in mice, Communications Biology, 8(1):1308, 2025.

2. Tao Chen#, Yang Zhang#, Liting Ding, Chenlu Xiong, Chao Mei, Sisi Wei, Ming Jiang, Yingjie Huang, Jianrong Chen, Tao Xie, Qing Zhu, Qi Zhang, Xuan Huang*, Shibiao Chen*, Yong Li*, Tripartite motif containing 65 deficiency confers protection against acute kidney injury via alleviating voltage-dependent anion channel 1-mediated mitochondrial dysfunction, MedComm, 6(6):e70149, 2025.

3. Sisi Wei#, Xuan Huang#, Qing Zhu, Tao Chen, Yan Zhang, Juan Tian, Tingyu Pan, Lv Zhang, Tao Xie, Qi Zhang, Xian Kuang, Enjun Lei, Yong Li*, TRIM65 deficiency alleviates renal fibrosis through NUDT21-mediated alternative polyadenylation, Cell Death and Differentiation, 31(11):1422-1438, 2024.

4. Qi Zhang#, Yong Li#, Qing Zhu, Tao Xie, Yue Xiao, Feng Zhang, Na Li, Keyu Deng, Hongbo Xin, Xuan Huang*, TRIM65 promotes renal cell carcinoma through ubiquitination and degradation of BTG3, Cell Death and Disease, 15:355, 2024.

5. Yingjie Huang, Tao Chen, Ming Jiang, Chenlu Xiong, Chao Mei, Jinping Nie, Qi Zhang, Qing Zhu, Xuan Huang*, Xuekang Zhang*, Yong Li*, E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis, Cell Death and Disease, 15:29, 2024.

6. Shuzhou Deng, Le Ding, Yisong Qian, Xuan Huang*, The role of ubiquitin-proteasome system (UPS) in asthma pathology, Journal of Asthma and Allergy, 18:307-330, 2025.

7. Wangxi Wu#, Jinyu Yang#, Tian Yu, Zhuoling Zou, Xuan Huang*, The role and mechanism of TRIM proteins in gastric cancer, Cells, 13(24):2107, 2024.

8. Kangning Li, Tao Xie, Yong Li, Xuan Huang*, LncRNAs act as modulators of macrophages within the tumor microenviroment, Carcinogenesis, 45(6):363-377, 2024.

9. Yue Xiao, Ruiqian Liu, Na Li, Yong Li, Xuan Huang*, Role of the ubiquitin-proteasome system on macrophages in the tumor microenvironment, Journal of Cellular Physiology, 239(2):e31180, 2024.

10. Sisi Wei#, Meiling Ai#, Yuan Zhan, Jieqing Yu, Tao Xie, Qinghua Hu, Yang Fang, Xuan Huang*, Yong Li*, TRIM14 suppressed the progression of NSCLC via hexosamine biosynthesis pathway, Carcinogenesis, 45(5):324-336, 2024.

11. Lei Zhou, Qi Zhang, Qing Zhu, Yuan Zhan, Yong Li*, Xuan Huang*, Role and therapeutic targeting of glutamine metabolism in non-small cell lung cancer, Oncology Letters, 25:159, 2023.

12. Yong Li, Qi Zhang, Na Li, Liting Ding, Jinping Yi, Yue Xiao, Shibiao Chen, Xuan Huang*, Ataxin-10 inhibits TNF-α-induced endothelial inflammation via suppressing interferon regulatory factor-1, Mediators of Inflammation, 2021: 7042148, 2021.

13. Yingjie Huang, Yue Xiao, Xuekang Zhang*, Xuan Huang*, Yong Li*, The emerging roles of tripartite motif proteins (TRIMs) in acute lung injury, Journal of Immunology Research, 2021:1007126, 2021.

14. Liting Ding#, Yang Fang#, Yong Li, Qinghua Hu, Meiling Ai, Keyu Deng, Xuan Huang*, Hongbo Xin*, AIMP3 inhibits cell growth and metastasis of lung adenocarcinoma through activating a miR-96-5p-AIMP3-p53 axis, Journal of Cellular and Molecular Medicine, 25(6): 3019-3030, 2021.

15. Xuan Huang, Yong Li, Daping Fan, Hongbo Xin*, Mingui Fu*, TRIM14 promotes endothelial activation via activating NF-κB signaling pathway, Journal of Molecular Cell Biology,12(3): 176-189, 2020.

16. Xuan Huang, Yong Li, Mingui Fu, Hongbo Xin*, Polarizing macrophages in vitro, Methods in Molecular Biology, 1784: 119-126, 2018.

17. Yong Li#, Xuan Huang#, Shengping Huang#, Hui He, Tianhua Lei, Fatma Saaoud, Xiaoqiang Yu, Ari Melnick, Anil Kumar, Christopher J Papasian, Daping Fan, Mingui Fu*, Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury, Signal Transduction and Targeted Therapy, 2: e17066, 2017. (#Co-first authors)

18. Xuan Huang, Mingjie Huang, Lingbao Kong, YongLi*, miR-372 suppresses tumour proliferation and invasion by targeting IGF2BP1 in renal cell carcinoma, Cell Proliferation, 48: 593-599, 2015.

Wei Wang#, Xuan Huang#, Hong-Bo Xin, Mingui Fu, Aimin Xue, Zhao-Hui Wu*, TRAF family member-associated NF-κB activator(TANK) inhibits genotoxic nuclear factor κB activation by facilitating deubiquitinase USP10-dependent deubiquitination of TRAF6 ligase, Journal of Biological Chemistry, 290(21): 13372-13385, 2015.(#Co-first authors)