Intelligent Respiratory and Inhalation Medicine Lab (IRIM Lab) 长期致力于肺再生生物学与吸入药物递送研究，融合单细胞组学（如单细胞/单核RNA测序、空间蛋白质组学）、精准吸入递送技术、人工智能computer vision驱动的成像分析（e.g., LungVis 1.0）及人源组织器官模型，探索慢性肺部疾病如特发性肺纤维化及呼吸道感染性疾病的发病机制和吸入治疗策略。

2008.09~2012.07：南昌大学生命科学与食品工程学院，生物技术专业，理学学士

2012.09~2015.07：南昌大学生命科学与食品工程学院， 微生物学专业，理学硕士

2015.10~2020.11：德国慕尼黑工业大学医学院,         实验医学专业，理学博士

2026.01~至今：南昌大学药学院与生物医学创新研究院/南昌大学第一附属医院 ,特聘研究员

2024.04~2025.11：DZL学院培训计划“呼吸医学职业发展

DZL Academy Mentoring Program "Careers in Respiratory Medicine"

2022.01~2025.12：Schiller and Schmid labs, 德国亥姆霍兹慕尼黑研究中心，肺健康和免疫所和精准再生医学研究单位 博士后和项目负责人

2021.04~2021.12：Schiller Lab, 德国亥姆霍兹慕尼黑研究中心，精准再生医学研究所， 博士后

2020.12~2021.03：Schmid Lab, 德国亥姆霍兹慕尼黑研究中心，肺健康和免疫所， 博士后

德国呼吸医学研究中心DZL学术会员

美国胸科协会ATS学术会员

德国呼吸学医师学术协会DGP会员

共同组织德国 DPLD Young Investigator Symposium学术会议, 2023, 德国海德堡

担任20余本多学科SCI期刊杂志审稿人，包括 Signal Transduction and Targeted Therapy, Frontiers in Immunology, Star Protocol, Particle and Fibre Toxicology, Frontiers in Cellular and Infection Microbiology, Small, Material Today Bio, Nanotoxicology等

 2025.07 德国DZL协会2025年度学术论文发表奖二等奖，海德堡，德国

 2025.04 德国DGP呼吸学医师协会2025年度实验医学论文奖，奖金1万欧，莱比锡，德国 相关新闻链接如下：Pressemitteilung

2025.02 CRSingapore2025 – 连接各洲递送科学大会最佳口头报告奖（之一），新加坡

2024.06 德国肺研究中心年度大会（DZL）成像组最佳海报奖，巴特瑙海姆，德国

2023.06 全德国亥姆霍兹成像中心举办的科学图片大赛最佳科学图片奖（“肺健康和免疫“科学图片荣获专业评审组第一名，奖金2000欧元），汉堡，德国。相关新闻链接如下：Best Scientific Image 2023: Who won this year’s contest? – helmholtz-imaging.de

2022.03 ERS肺科学大会旅行奖，埃斯托里尔，葡萄牙

2019.05 第6届Nano today 大会旅行奖，里斯本，葡萄牙

2018.09 Nanotox 2018 - 第九届国际纳米毒理学会议海报奖，诺伊斯，德国

2018.09 第11届欧洲及全球临床纳米医学峰会基础纳米医学海报一等奖，巴塞尔，瑞士

2015.06 南昌大学一等奖学金，南昌大学优秀硕士毕业生等，南昌，中国

2014.06 中国教育部国家研究生奖学金，江西省研究生创新专项基金等，南昌，中国

一：主要科研成果

已发表20余篇SCI论文，其中一作和通讯作者文章10余篇，包括Nature Reviews Bioengineering, Nature Communications, ACS Nano, Advanced Science等，以主要合作者发表Science Translation Medicine 和 Science Advances文章等。

1、 主持科研课题

杨林. 开发LungVis系统探究吸入mRNA递送和治疗肺纤维化，国家自然科学基金面上项目，49万元，2026-2029，No. 82572312

2、 发表代表性论文

类别 A (同行评审的SCI论文)

[1] Yang L^{*(Co-Corresponding)}, Han L^*, Schmid O, Chen C^*. Precision dosimetry in pulmonary drug delivery,Nature Reviews Bioengineering, 2025, https://doi.org/10.1038/s44222-025-00356-9

[2] Liu Q, Yang L, Li C, Han L, Wilmot J, … & Rehberg M, Alveolar macrophages initiate the spatially targeted recruitment of neutrophils after nanoparticle inhalation, Sciences Advances, 2025, 11 (45):edax8586

[3] Yang L^{*(Co-Corresponding)}, Liu Q, Kumar P, Sengupta, A…., Schmid O*. LungVis 1.0: an automatic AI-powered 3D imaging ecosystem unveils spatial profiling of nanoparticle delivery and acinar migration of lung macrophages, Nature Communications, 2024, 10138 (15).https://doi.org/10.1038/s41467-024-54267-1

[4] Zhou Q+, Liu Q+, Wang Y, Chen, J*, Schmid O, Rehberg M, Yang L^{*(Last Corresponding)}, Bridging smart nanobiotechnology with clinically relevant models and advanced imaging for precision drug delivery, Advanced Science, 2024, 2308659, https://doi.org/10.1002/advs.202308659

[5] Lang, NJ, Gote-Schniering J, Gonzalez. DP, Yang L,...& Schiller H. Ex vivo tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis.Science Translational Medicine, 2023, 15(725), DOI:10.1126/scitranslmed.adh0908

[6] Yang, L, Feuchtinger, A, Möller, W, et al. Three-Dimensional Quantitative Co-Mapping of Pulmonary Morphology and Nanoparticle Distribution with Cellular Resolution in Nondissected Murine Lungs [J].ACS Nano 2019, 13 (2): 1029-1041. Wide public dissemination in Twitter/X https://twitter.com/acsnano/status/1086313340102758403

[7] Yang, L, Gradl, R, Dierolf, M,... Schmid O. Multimodal precision imaging of pulmonary nanoparticle delivery in mice: Dynamics of application, spatial distribution, and dosimetry [J]. Small 2019, DOI:10.1002/smll.201904112

TUM press release https://www.bioengineering.tum.de/news/details/precise-monitoring-of-the-lung

[8] Yang L, Kuang H, Zhang W, Wei H, Xu H. Quantum dots cause acute systemic toxicity in lactating rats and growth restriction of offspring. Nanoscale, 2018, 10(24):11564-77

[9] Yang L, Kuang H, Zhang W, et al. Size dependent biodistribution and toxicokinetics     of iron oxide magnetic nanoparticles in mice [J]. Nanoscale, 2015, 7(2): 625-636.

[10] Yang L, Kuang H, Liu Y, et al. Mechanism of enhanced antibacterial activity of ultra-fine ZnO in phosphate buffer solution with various organic acids [J]. Environmental Pollution, 2016, 218:863-869.

[11] Yang L, Kuang H, Zhang W, et al. Comparisons of the biodistribution and toxicological examinations after repeated intravenous administration of silver and gold nanoparticles in mice [J]. Scientific Reports, 2017

[12] Zhang W⁺, Yang L⁺, Kuang H⁺, et al. Acute toxicity of quantum dots on late pregnancy mice:Effects of nanoscale size and surface coating [J]. Journal of Hazardous Materials, 2016, 318:61-69.

[13] Kuang H⁺, Zhang W⁺, Yang L⁺, et al. Reproductive organ dysfunction and gene expression after orally administration of ZnO nanoparticles in murine, Environmental Toxicology, 2020.

[14] Yang L, Aguilar Z P, Qu F, et al. Enhanced antimicrobial activity of silver nanoparticles-Lonicera Japonica Thunb combo [J]. IET nanobiotechnology, 2016, 10(1): 28-32.

[15] Estaji, M., Nabaei, M., Yang, L., Schmid, O., & Farnoud, A. . Aerosol dosimetry in the whole conducting zone of a murine left-lung using CF-PD and LSFM images. Journal of Aerosol Science 2024, 181, 106425.

[16] Gradl, R., Dierolf, M., Yang, L., Hehn, L., et al., Visualizing treatment delivery and deposition in mouse lungs using in vivo x-ray imaging. Journal of Controlled Release. 2019.

[17] Doryab, A., Tas, S., Taskin, M. B., Yang, L., Hilgendorff, A., Groll, J. & Schmid, O. Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology. Advanced Functional Materials, 2019, 1903114

[18] Kuang H, Yang L, Shah N P, et al. Synergistic in vitro and in vivo antimicrobial effect of a mixture of ZnO nanoparticles and Lactobacillus fermentation liquor [J]. Applied microbiology and biotechnology, 2016, 100(8): 3757-3766.

[19] Kuang H, Yang P, Yang L, et al. Size dependent effect of ZnO nanoparticles on endoplasmic reticulum stress signaling pathway in murine liver [J]. Journal of hazardous materials, 2016, 317:119-126.

[20] Ehrmann, S., Schmid, O., Darquenne, C., Rothen-Rutishauser, B., Sznitman, J., Yang, L., Barosova,H., Vecellio, L., Mitchell, J. and Heuze-Vourc’h, N., Innovative preclinical models for pulmonary drug delivery research. Expert Opinion on Drug Delivery, 2020. 17(4), pp.463-478.

[21] Bölükbas, D.A., Datz, S., Meyer-Schwickerath, C., Morrone, C., Doryab, A., Gößl, D., Vreka, M.,Yang, L., et al. Organ-Restricted Vascular Delivery of Nanoparticles for Lung Cancer Therapy.Advanced Therapeutics, 2020. p.2000017.

类别B (其他形式的学术成果发表，如开源的软件/数据库等)

[1] LungVis 1.0 的原始和处理的数据库

Yang, L., Schmid, O. & Isensee, F. LungVis1.0: Active learning AI-powered 3D imaging ecosystem for spatial profiling of lung geometry and pulmonary nanoparticle delivery. Zenodo, (2023). 数据链接https://doi.org/10.5281/zenodo.7413818

Note: 截止2026年1月，LungVis1.0原始数据和AI处理数据库已被下载超9000次，数据量超32TB.

[2] LungVis 1.0 AI代码

Isensee, F., Yang, L., Ziegler, S., Trofimova, D. & Schmid, O. LungVis 1.0: an automatic AI-powered 3D imaging ecosystem unveils spatial profiling of nanoparticle delivery and acinar migration of lung macrophages. Zenodo, (2024). https://doi.org/10.5281/zenodo.13898278