中枢神经、肿瘤、代谢性疾病的药物靶点发现与确证、新药开发

2008-2011，香港中文大学，药学院，博士

2005-2008，首都师范大学（中国科学院生物物理所联合培养），硕士

2001-2005，中国农业大学，生物学院，学士

2025-至今，南昌大学研究生院副院长

2024-至今，教育部实体肿瘤分子靶向医药基础研究创新中心副主任

2024-至今，新药靶点发现与确证江西省重点实验室主任

2020-2024，南昌大学药学院副院长

2017-2024，江西省药物靶点与新药筛选重点实验室副主任

2021-2022，复旦大学上海医学院学科规划与双一流办处长助理（挂职）

2016-2020，南昌大学药学院新药研发中心主任

2015-至今，南昌大学，药学院，教授

2024-至今 理事长, 江西省细胞生物学学会

2023-至今 理事,中国细胞生物学学会

2022-至今 理事,中国医药教育协会医学基因组与生物信息学专委会

2021-至今 副主委, 江西省药学会基础药理学专委会

2016-至今 常务理事, 江西省神经学会

2019-2024 秘书长, 江西省细胞生物学学会

2019-至今 常务理事, 江西省抗癫痫协会

2018-至今 理事, 国际抗癫痫联盟植物药特别委员会

2016-至今 理事, 江西省儿童神经病学专委会

2018-2022 理事, 中国肿瘤协会肿瘤代谢专委会

2011-2015 会员, AAAS/Science

学术期刊编委： Military Medical Research ，Anti-tumor Pharmacy, Data in Brief (2018-2022).

审稿人（Reviewer）：Molecular Therapy, Neuropharmacology, Epilepsia, Liver International, The International Journal of Neuroscience.

2022 江西省省级人才 I 类

2020 江西省省级人才 I 类青年

2018 江西省省级人才

2012 澳大利亚“奋进”奖

一、 主要科研成果

从事新药靶点发现与确证、新药开发研究，在药物靶点发现、药理学、癫痫/肿瘤/代谢系统疾病的发病机制研究方面取得了一系列突出成果，在Adv Drug Deliv Rev、 J Adv Res、eLife、Protein & Cell、Epilepsia等著名期刊上发表高水平论文 40余篇，多次受邀在国际学术大会上作学术报告。主持国家自然科学基金5项（含面上、国际合作、青年等项目）、省自然科学基金重点项目3项。现任教育部实体肿瘤分子靶向医药基础研究创新中心副主任，新药靶点发现与确证江西省重点实验室主任，江西省细胞生物学学会理事长。与美国、澳大利亚、香港、中科院有密切科研合作。

（一）主持科研课题：

1. 教育部实体肿瘤分子靶向医药基础研究创新中心， 2023.5-至今，主持

2. 新药靶点发现与确证江西省重点实验室:      50万，2024.3-至今，主持

3. 江西省“双千”计划-自然科学领军人才: 200万，2023.1-2026.12，主持；

4. 国自然-地区项目：术中精准定位耐药性癫痫灶的P-糖蛋白靶向荧光探针合成筛选与性能研究，34万，2022.1-2025.12,主持；

5. 国自然-地区项目：姜黄素纳米粒子调控ABC转运体抑制癫痫耐药性的作用，36万，2019.1-2022.12,主持；

6. 国自然-面上项目：基于人源化小鼠研究MDR1基因多态性对耐药性癫痫的影响及其机制，60万，2018.1-2021.12，主持；

7. 国自然-海外合作项目：P-gp荧光底物辅助耐药性癫痫精准手术的开发与评估，18万， 2018.1-2019.12，国内合作主持；

8. 国自然-青年项目：ABCB1核苷酸多态性对P-糖蛋白转运抗癫痫药物的影响，17.5万，2016.1-2018.12，主持；

9. 江西省自然科学基金管理科学类（战略支撑）项目：科技评估评价体系建设战略研究，10万，2024.12-2025.11，主持；

10. 江西省杰出青年人才资助计划 （省青年科学家），15万，2018.1-2020.12，主持；

11. 横向课题：APOa 靶点蛋白纯化与药物筛选，30万，2024.11-2025.6，主持；

12. 横向课题：非酒精性脂肪肝诊断靶点的发现及技术研究，20万，2023.12-2025.11, 主持。

（二）发表代表性论文：

1. Zhang C, Liu D. Transcription Factor Binding Site in Promoter Determines the Pattern of Plasmid-Based Transgene Expression In Vivo. Pharmaceutics. 2024 Apr 15;16(4):544. doi: 10.3390/pharmaceutics16040544. PMID: 38675205; PMCID: PMC11055139.

2. Shen L, Yang Y, Lu L, Huang J, He W, Zhao C, Guo F, Zhang C, Zhong H, Liao F. Design and synthesis of piperine-based photoaffinity probes for revealing potential targets of piperine in neurological disease. Chem Commun (Camb). 2025 Jan 7;61(4):669-672. doi: 10.1039/d4cc04330h. PMID: 39628399.

3. Zhao Z, Zhu J, Zhou L, Sun N, Chang K, Hu X, Hu Y, Ren M, Cheng Y, Xu D, Xin H, Zhang C. Establishment of a hydrodynamic delivery system in ducks. Transgenic Res. 2024 Apr;33(1-2):35-46. doi: 10.1007/s11248-024-00377-x. Epub 2024 Mar 9. PMID: 38461212.

4. Zhu H, Wu Z, Yu Y, Chang K, Zhao C, Huang Z, He W, Luo Z, Huang H, Zhang C. Integrated non-targeted metabolomics and network pharmacology to reveal the mechanisms of berberine in the long-term treatment of PTZ-induced epilepsy. Life Sci. 2024 Jan 1:336:122347. doi: 10.1016/j.lfs.2023.122347.

5. Chunfang Zhao, Ben Rollo, Shahid Javaid, Ziyu Huang, Wen He, Hong Xu, Patrick Kwan, Chunbo Zhang. An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds. J Adv Res. 2023 Nov 22:S2090-1232(23)00361-2. doi: 10.1016/j.jare.2023.11.022.

6. Luo W, Li Y, Zeng Y, Li Y, Cheng M, Zhang C, Li F, Wu Y, Huang C, Yang X, Kremerskothen J, Zhang J, Zhang C, Tu S, Li Z, Luo Z, Lin Z, Yan X. Tea Domain Transcriptional Factor 4 (TEAD4) mitigates TGF-β signaling and hepatocellular carcinoma progression independently of YAP. J Mol Cell Biol. 2023 Feb 20;mjad010. doi: 10.1093/jmcb/mjad010.

7. Zeng Y, Lv Y, Hu M, Guo F, Zhang C. Curcumin-loaded hydroxypropyl-β-cyclodextrin inclusion complex with enhanced dissolution and oral bioavailability for epilepsy treatment. Xenobiotica. 2022 Oct 24:1-11. doi: 10.1080/00498254.2022.2136044. Epub ahead of print. PMID: 36227237.

8. Ren M, Pan J, Yu X, Chang K, Yuan X, Zhang C. CTRP1 prevents high fat diet-induced obesity and improves glucose homeostasis in obese and STZ-induced diabetic mice. J Transl Med. 2022 Oct 4;20(1):449. doi: 10.1186/s12967-022-03672-5. PMID: 36195912; PMCID: PMC9533627.

9. Lyu Y, Li D, Yuan X, Li Z, Zhang J, Ming X, Shaw PC, Zhang C, Kong APS, Zuo Z. Effects of combination treatment with metformin and berberine on hypoglycemic activity and gut microbiota modulation in db/db mice. Phytomedicine. 2022 Apr 23;101:154099.

10. Liu Z, Wang M, Zhang C, Zhou S, Ji G. Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology. Diabetes Metab Syndr Obes. 2022 Mar 3;15:695-711.

11. Zhang C, Zhong T, et, al. The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis. Elife. 2021 Nov 5;10:e70672.

12. Han XJ, Zhang WF, Wang Q, Li M, Zhang C, Yang ZJ, Tan RJ, Gan LJ, Zhang LL, Lan XM, Zhang FL, Hong T, Jiang LP. HIF-1α promotes the proliferation and migration of pulmonary arterial smooth muscle cells via activation of Cx43. J Cell Mol Med. 2021 Nov;25(22):10663-10673.

13. Fei Z, Hu M, Baum L, Kwan P, Hong T, Zhang C. The potential role of human multidrug resistance protein 1 (MDR1) and multidrug resistance-associated protein 2 (MRP2) in the transport of Huperzine A in vitro. Xenobiotica. 2020 Mar;50(3):354-362.

14. Liu L, Wu Y, Zhang C, Zhou C, Li Y, Zeng Y, Zhang C, Li R, Luo D, Wang L, Zhang L, Tu S, Deng H, Luo S, Chen YG, Xiong X, Yan X. Cancer-associated adipocytes-derived G-CSF promotes breast cancer malignancy via Stat3 signaling. J Mol Cell Biol. 2020 Sep 1;12(9):723-737. doi: 10.1093/jmcb/mjaa016.

15. Lu B, Zhong J, Pan J, Yuan X, Ren M, Jiang L, Yang Y, Zhang G, Liu D, Zhang C. Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice. J Transl Med. 2019 Dec 17;17(1):422.

16. Ren T, Xiao M, Yang M, Zhao J, Zhang Y, Hu M, Cheng Y, Xu H, Zhang C, Yan X, Zuo Z. Reduced Systemic and Brain Exposure with Inhibited Liver Metabolism of Carbamazepine After Its Long-Term Combination Treatment with Piperine for Epilepsy Control in Rats. AAPS J. 2019 Jul 18;21(5):90.

17. Ren T, Hu M, Cheng Y, Shek TL, Xiao M, Ho NJ, Zhang C, Leung SSY, Zuo Z. Piperine-loaded nanoparticles with enhanced dissolution and oral bioavailability for epilepsy control. Eur J Pharm Sci. 2019 Sep 1;137:104988.

18. Zhang C, Kwan P. The Concept of Drug-Resistant Epileptogenic Zone. Front Neurol. 2019 May 31;10:558.

19. Guo X, Zhang C. Research Progress of Optogenetic Techniques. China Biotechnology. 2019, Issue3.

20. Zhang C，Zhang G, Liu D. Histone Deacetylase Inhibitors Reactivate Silenced Transgene in Vivo. Gene Ther. 2019 Apr;26(3-4):75-85.

21. Gao M，Zhang C，Ma Y，Liu D. Cold Exposure Improves the Anti-diabetic Effect of T0901317 in Streptozotocin-Induced Diabetic Mice.，AAPS J. 2015 May;17(3):700-10.

22. Chan PS, Zhang C, Zuo Z, Kwan P, Baum L. In vitro transport assays of rufinamide, pregabalin, and zonisamide by human P-glycoprotein. Epilepsy Res. 2014 Mar;108(3):359-66.

23. Baum L, Haerian BS, Ng HK, Wong VC, Ng PW, Lui CH, Sin NC, Zhang C, Tomlinson B, Wong GW, Tan HJ, Raymond AA, Mohamed Z, Kwan P. Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy. Hum Genet. 2014 May;133(5):651-9.

24. Gao M, Zhang C, Ma Y, Bu L, Yan L, Liu D. Hydrodynamic delivery of mIL10 gene protects mice from high-fat diet-induced obesity and glucose intolerance. Mol Ther. 2013 Oct;21(10):1852-61.

25. Zhang C, Chanteux H, Zuo Z, Kwan P, Baum L. Potential role for human P-glycoprotein in the transport of lacosamide. Epilepsia. 2013 Jul;54(7):1154-60.

26. Zhang C, Kwan P, Zuo Z, Baum L. The transport of antiepileptic drugs by P-glycoprotein. Adv Drug Deliv Rev. 2012 Jul; 64(10):930-42.

27. Zhang C, Zuo Z, Kwan P, Baum L. In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their active metabolites by human P-glycoprotein. Epilepsia. 2011 Oct; 52(10):1894-904.

28. Zhang C, Liu Y, Hu Z, An L, He Y, Hang H. Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses. Protein & Cell. 2011 May; 2(5):410-22.

29. Zhang C, Wong V, Ng PW, Lui CH, Sin NC, Wong KS, Baum L, Kwan P. Failure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile seizures in Chinese patients with epilepsy. Epilepsia. 2010 Sep; 51(9):1878-81.

30. Zhang C, Kwan P, Zuo Z, Baum L. In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein. Life Sci. 2010 Jun 5; 86(23-24):899-905.

31. Zhang C, Zhang CX, He Y, Hang H. Phosphorylation sites on Tyr28 and the C-terminus of Rad9 are required for inhibition of premature chromosomal condensation across the entire S phase. Cell Physiol Biochem. 2008; 22(1-4):295-306.

32. He W, Zhao Y, Zhang C, An L, Hu Z, Liu Y, Han L, Bi L, Xie Z, Xue P, Yang F, Hang H. Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1. Nucleic Acids Res. 2008 Nov; 36(20):6406-17.

33. Hu Z, Liu Y, Zhang C, Zhao Y, He W, Han L, Yang L, Hopkins KM, Yang X, Lieberman HB, Hang H. Targeted deletion of Rad9 in mouse skin keratinocytes enhances genotoxin-induced tumor development. Cancer Res. 2008 Jul 15; 68(14):5552-61.

（三）专利：

1. 张春波， 关国良， 赵春芳，程研。一种含7-羟基香豆素结构基团的荧光化合物, 2022-07-12, 中国, ZL202210190982.X

2. 张春波， 关国良， 赵春芳，程研。一种含7-甲基香豆素结构基团的荧光化合物, 2022-07-15, 中国, ZL202210194958.3

3. 张春波， 关国良， 赵春芳，程研。一种含萘酰亚胺结构基团的荧光化合物, 2022-07-12, 中国, ZL202210190983.4

4. 张春波， 关国良， 赵春芳，程研。一种含7-氨基香豆素结构基团的荧光化合物, 2022-07-08, 中国, ZL202210257719.8

5. 张春波， 关国良， 赵春芳，程研。一种含7-氰基香豆素结构基团的荧光化合物, 2022-07-08, 中国, ZL202210257742.7