
姓名:汪琪
职称:特聘研究员
邮箱:wangqi07@ncu.edu.cn
籍贯: 山东兖州
导师类型:博士生导师
主讲课程:
个人主页:
紫外追踪指导下的西沙海绵来源特色生物碱新结构的高效发现;适用于海洋小分子的生物活性高通量筛选模型构建及海洋药物先导化合物的深度挖掘;粗酶反应指示下的海绵来源特色生物碱家族的生物合成研究。
2007.09—2011.06:青岛农业大学,生物科学专业,理学学士
2011.09—2016.06:中国海洋大学,药物化学专业,医学博士
2016.09—2020.07:青岛大学慢病研究院 讲师
2017.01—2018.12:中科院合肥物质科学研究院 博士后
2020.08—2023.12:青岛大学药学院 讲师
2024.01—2025.09:青岛大学药学院 副教授
2025.10—至今:南昌大学药学院 特聘研究员
2015年教育部博士研究生国家奖学金
2021年中国海洋学会海洋科学技术奖二等奖(第三位次)
2023年获评青岛大学药学院办学20周年/建院10周年科研标兵
一、 主要科研成果
1、 主持科研课题
[1] 国家自然科学基金面上项目,项目名称:海绵Stylissa massa靶向醛糖还原酶ALR2的生物碱成分高效发现及作用机制研究,课题负责人:汪琪,2023-2026(52万)
[2] 国家自然科学基金青年项目,项目名称:两种西沙群岛软珊瑚中抗血管生成活性nardosinane型倍半萜的发现,课题负责人:汪琪,2020-2022(25万)
[3] 科技部重点研发计划青年科学家项目子课题,项目名称:深海含杂原子先导化合物的高效发现与深度挖掘技术研究,子课题负责人:汪琪,2022-2025(60万)
2、 发表代表性论文
1. Peng, D.; Luo, X. C.; Zhu, R. W.; Tong, W. L.; Yang, Y. N.; Li, G. Q.; Wang, Q.* Tagpyrrollins A and B and Tagpyrrollidone A: Three Pyrrole Steroid Analogues with AKR1B1-Targeting Inhibitory Activity from the Sponges Stylissa massa and Pseudospongosorites suberitoides. Organic Letters, 2024, 26, 5794-5798.
2. Liu, X. J.†; Wang, Q.†; Zhang, Y.*; Zhang, H. T.* Discovery of Anti-Inflammatory Alkaloids from Sponge Stylissa massa Suggests New Biosynthetic Pathways for Pyrrole–Imidazole Alkaloids. Marine Drugs, 2024, 22, 477.
3. Wang, Q.; Gao, C. H.; Wei, Z.; Tang, X. W.; Ji, L. X.; Luo, X. C.; Peng, X. P.; Li, G.; Lou, H. X.* A Series of New Pyrrole Alkaloids with ALR2 Inhibitory Activities from the Sponge Stylissa massa. Marine Drugs, 2022, 20, 454.
4. Cheng, M. M.; Cui, X. C.; Tang, Y.; Shao, Z. Z.; Liu, X. P.; Su, J. C.; Zhang, J.; Wang, Q.*; Li, G. Q.* Total Synthesis of Leptochartamides A and B: Two Enantiomeric Pairs of Hydroxybenzyl Dimers from a Deep-Sea Fungus Leptosphaerulina chartarum. The Journal of Organic Chemistry, 2022, 87, 11090-11096.
5. Han, X.†; Wang, Q.†,*; Luo, X. C.; Tang, X. L.; Wang, Z.; Zhang, D.; Cao, S. G.; Li, P. L.*; Li, G. Q.* Lemnalemnanes A−C, Three Rare Rearranged Sesquiterpenoids from the Soft Corals Paralemnalia thyrsoides and Lemnalia sp. Organic Letters, 2022, 24, 11-15.
6. Cheng, M. M.; Li, P. L.*; Jiang, Y.; Tang, X. L.; Zhang, W. J.; Wang, Q.*; Li, G. Q.* Penitol A and Penicitols E−I: Citrinin Derivatives from Penicillium citrinum and the Structure Revision of Previously Proposed Analogues. Journal of Natural Products, 2021, 84, 1345-1352.
7. Luo, X. C.†; Wang, Q.†,*; Tang, X. L.; Xu, J. X.; Wang, M. X.; Li, P. L.*; Li, G. Q.* One cytotoxic steroid and other two new metabolites from the South China Sea sponge Luffariella variabilis. Tetrahedron Lett., 2021, 65, 152762.
8. Luo, X. C.†; Wang, Q.†; Tang, X. L.; Li, P. L.*; Li, G. Q.* Cytotoxic Manoalide-Type Sesterterpenes from the Sponge Luffariella variabilis Collected in the South China Sea. Journal of Natural Products, 2021, 84, 61-70.
9. Liu, M. Y.; Li, P. L.*; Tang, X. L.; Luo, X. C.; Liu, K. C.; Zhang, Y.; Wang, Q.*; Li, G. Q.* Lemnardosinanes A-I: New Bioactive Sesquiterpenoids from Soft Coral Lemnalia sp. The Journal of Organic Chemistry, 2021, 86, 970-979.
10. Wang, Q.; Sun, Y. T.; Yang, L.; Luo, X. C.; Voogd, N. J. D.; Tang, X. L.; Li, P. L.*; Li, G. Q.* Bishomoscalarane Sesterterpenoids from the Sponge Dysidea granulosa Collected in the South China Sea. Journal of Natural Products, 2020, 83, 516-523.
11. Wang, Q.; Tang, X. L.; Liu, H.; Luo, X. C.; Sung, P. J.; Li, P. L.*; Li, G. Q.* Clavukoellians G–K, New Nardosinane and Aristolane Sesquiterpenoids with Angiogenesis Promoting Activity from the Marine Soft Coral Lemnalia sp. Marine Drugs, 2020, 18, 171.
12. Wang, Q.; Hu, Z. Q.; Luo, X. C.; Liu, J.; Li, G. Q.*; Cao, S. G.*; Liu, Q. S.* Clavukoellians A−F, Highly Rearranged Nardosinane Sesquiterpenoids with Antiangiogenic Activity from Clavularia koellikeri. Journal of Natural Products, 2019, 82, 1331-1337.
13. Wang, Q.; Hu, Z. Q.; Li, X. X.; Wang, A. L.; Wu, H.; Liu, J.; Cao, S. G.*; Liu, Q. S.* Salviachinensines A−F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis. Journal of Natural Products, 2018, 81, 2531-2538.
14. Wang, Q.; Tang, X. L.; Luo, X. C.; Voogd, N. J. D.; Li, P. L.*; Li, G. Q.* (+)- and (−)-Spiroreticulatine, A Pair of Unusual Spiro Bisheterocyclic Quinoline-imidazole Alkaloids from the South China Sea Sponge Fascaplysinopsis reticulata. Organic Letters, 2015, 17, 3458-3461.
3、 国家专利:
[1] 汪琪;刘筱婧;张汉霆;一种海绵来源的生物碱四聚体及其高效制备方法与应用,202410507712.6
[2] 汪琪;朱润为;彭笛;韩梅;一类海绵来源吡咯咪唑生物碱二聚体的制备方法及应用,202511201486X
[3] 张汉霆;高春华;汪琪;王哲;董铭心;刘筱婧;一种磷酸二酯酶抑制剂的高通量筛选方法,CN202311146827.9