针对肥胖和糖尿病、神经系统疾病的药理学研究和新药研发

2008-2011，香港中文大学，药学院，博士

2005-2008，首都师范大学（中科院生物物理所联合培养），硕士

2001-2005，中国农业大学，生物学院，学士

2021-2022, 复旦大学上海医学院学科规划与双一流办处长助理（挂职）

2020-至今，南昌大学药学院副院长

2017-至今，江西省药物靶点与新药筛选重点实验室副主任

2015-至今，南昌大学，药学院，教授

2011-2014，美国佐治亚大学，药学与生物医学系，博士后

2021-2022, 复旦大学上海医学院学科规划与双一流办处长助理（挂职）

2020-至今，南昌大学药学院副院长

2017-至今，江西省药物靶点与新药筛选重点实验室副主任

2015-至今，南昌大学，药学院，教授

2011-2014，美国佐治亚大学，药学与生物医学系，博士后

2018 入选省级人才

2012澳大利亚“奋进”奖

一、 主要科研成果

从事癫痫、肥胖和糖尿病等疾病的新药开发和药理学研究，在基因治疗、生物制药、耐药性癫痫方面取得了一系列突出成果，在Adv Drug Deliv Rev、eLife、Protein & Cell、Epilepsia等著名期刊上发表高水平论文20余篇，多次受邀在国际学术大会上作学术报告。主持国家自然科学基金5项（含面上、国际合作等项目）、省自然科学基金重点项目3项。现为Molecular Therapy、Neuropharmacology、Epilepsia、Liver International 等高水平SCI杂志审稿人。

（一）主持科研课题：

1. 国自然-地区项目：术中精准定位耐药性癫痫灶的P-糖蛋白靶向荧光探针合成筛选与性能研究，34万，2022.1-2025.12, 主持；

2. 国自然-地区项目：姜黄素纳米粒子调控ABC转运体抑制癫痫耐药性的作用，36万，2019.1-2022.12, 主持；

3. 国自然-面上项目：基于人源化小鼠研究MDR1基因多态性对耐药性癫痫的影响及其机制，60万，2018.1-2021.12，主持；

4. 国自然-海外合作项目：P-gp荧光底物辅助耐药性癫痫精准手术的开发与评估，18万， 2018.1-2019.12，国内合作主持；

5. 国自然-青年项目：ABCB1核苷酸多态性对P-糖蛋白转运抗癫痫药物的影响，17.5万，2016.1-2018.12，主持；

6. 省自然基金-重点项目：辅助耐药性癫痫病灶精准切除的荧光化合物探针的开发与评估，20万， 2021.1-2023.12，主持；

7. 江西省杰出青年人才资助计划 （省青年科学家），15万，2018.1-2020.12， 主持；

8. 省自然基金-重点项目：姜黄素纳米粒子调控大脑ABC转运体抑制癫痫耐药性的机制和疗效研究，20万， 2017.1-2019.12，主持；

9. 江西省自然科学基金：核苷酸多态性位点 2677G>T/A 对P-glycoprotein转运抗癫痫药物的影响及机制研究，7万，2016.1-2018.12，主持；

10. 江西省教育厅项目：不同器官微环境对免疫疗法和靶向药物治疗非小细胞肺癌的影响，2万，2016.1- 2017.12，主持；

（二）发表代表性论文：

[1] Zeng Y, Lv Y, Hu M, Guo F, Zhang C. Curcumin-loaded hydroxypropyl-β-cyclodextrin inclusion complex with enhanced dissolution and oral bioavailability for epilepsy treatment. Xenobiotica. 2022 Oct 24:1-11. doi: 10.1080/00498254.2022.2136044. Epub ahead of print. PMID: 36227237.

[2] Ren M, Pan J, Yu X, Chang K, Yuan X, Zhang C. CTRP1 prevents high fat diet-induced obesity and improves glucose homeostasis in obese and STZ-induced diabetic mice. J Transl Med. 2022 Oct 4;20(1):449. doi: 10.1186/s12967-022-03672-5. PMID: 36195912; PMCID: PMC9533627.

[3] Lyu Y, Li D, Yuan X, Li Z, Zhang J, Ming X, Shaw PC, Zhang C, Kong APS, Zuo Z. Effects of combination treatment with metformin and berberine on hypoglycemic activity and gut microbiota modulation in db/db mice. Phytomedicine. 2022 Apr 23;101:154099.

[4] Liu Z, Wang M, Zhang C, Zhou S, Ji G. Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology. Diabetes Metab Syndr Obes. 2022 Mar 3;15:695-711.

[5] Zhang C, Zhong T, et, al. The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis. Elife. 2021 Nov 5;10:e70672.

[6] Han XJ, Zhang WF, Wang Q, Li M, Zhang C, Yang ZJ, Tan RJ, Gan LJ, Zhang LL, Lan XM, Zhang FL, Hong T, Jiang LP. HIF-1α promotes the proliferation and migration of pulmonary arterial smooth muscle cells via activation of Cx43. J Cell Mol Med. 2021 Nov;25(22):10663-10673.

[7] Fei Z, Hu M, Baum L, Kwan P, Hong T, Zhang C. The potential role of human multidrug resistance protein 1 (MDR1) and multidrug resistance-associated protein 2 (MRP2) in the transport of Huperzine A in vitro. Xenobiotica. 2020 Mar;50(3):354-362.

[8] Liu L, Wu Y, Zhang C, Zhou C, Li Y, Zeng Y, Zhang C, Li R, Luo D, Wang L, Zhang L, Tu S, Deng H, Luo S, Chen YG, Xiong X, Yan X. Cancer-associated adipocytes-derived G-CSF promotes breast cancer malignancy via Stat3 signaling. J Mol Cell Biol. 2020 Sep 1;12(9):723-737. doi: 10.1093/jmcb/mjaa016.

[9] Lu B, Zhong J, Pan J, Yuan X, Ren M, Jiang L, Yang Y, Zhang G, Liu D, Zhang C. Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice. J Transl Med. 2019 Dec 17;17(1):422.

[10] Ren T, Xiao M, Yang M, Zhao J, Zhang Y, Hu M, Cheng Y, Xu H, Zhang C, Yan X, Zuo Z. Reduced Systemic and Brain Exposure with Inhibited Liver Metabolism of Carbamazepine After Its Long-Term Combination Treatment with Piperine for Epilepsy Control in Rats. AAPS J. 2019 Jul 18;21(5):90.

[11] Ren T, Hu M, Cheng Y, Shek TL, Xiao M, Ho NJ, Zhang C, Leung SSY, Zuo Z. Piperine-loaded nanoparticles with enhanced dissolution and oral bioavailability for epilepsy control. Eur J Pharm Sci. 2019 Sep 1;137:104988.

[12] Zhang C, Kwan P. The Concept of Drug-Resistant Epileptogenic Zone. Front Neurol. 2019 May 31;10:558.

[13] Guo X, Zhang C. Research Progress of Optogenetic Techniques. China Biotechnology. 2019, Issue3.

[14] Zhang C，Zhang G, Liu D. Histone Deacetylase Inhibitors Reactivate Silenced Transgene in Vivo. Gene Ther. 2019 Apr;26(3-4):75-85.

[15] Gao M，Zhang C，Ma Y，Liu D. Cold Exposure Improves the Anti-diabetic Effect of T0901317 in Streptozotocin-Induced Diabetic Mice.，AAPS J. 2015 May;17(3):700-10.

[16] Chan PS, Zhang C, Zuo Z, Kwan P, Baum L. In vitro transport assays of rufinamide, pregabalin, and zonisamide by human P-glycoprotein. Epilepsy Res. 2014 Mar;108(3):359-66.

[17] Baum L, Haerian BS, Ng HK, Wong VC, Ng PW, Lui CH, Sin NC, Zhang C, Tomlinson B, Wong GW, Tan HJ, Raymond AA, Mohamed Z, Kwan P. Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy. Hum Genet. 2014 May;133(5):651-9.

[18] Gao M, Zhang C, Ma Y, Bu L, Yan L, Liu D. Hydrodynamic delivery of mIL10 gene protects mice from high-fat diet-induced obesity and glucose intolerance. Mol Ther. 2013 Oct;21(10):1852-61.

[19] Zhang C, Chanteux H, Zuo Z, Kwan P, Baum L. Potential role for human P-glycoprotein in the transport of lacosamide. Epilepsia. 2013 Jul;54(7):1154-60.

[20] Zhang C, Kwan P, Zuo Z, Baum L. The transport of antiepileptic drugs by P-glycoprotein. Adv Drug Deliv Rev. 2012 Jul; 64(10):930-42.

[21] Zhang C, Zuo Z, Kwan P, Baum L. In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their active metabolites by human P-glycoprotein. Epilepsia. 2011 Oct; 52(10):1894-904.

[22] Zhang C, Liu Y, Hu Z, An L, He Y, Hang H. Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses. Protein & Cell. 2011 May; 2(5):410-22.

[23] Zhang C, Wong V, Ng PW, Lui CH, Sin NC, Wong KS, Baum L, Kwan P. Failure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile seizures in Chinese patients with epilepsy. Epilepsia. 2010 Sep; 51(9):1878-81.

[24] Zhang C, Kwan P, Zuo Z, Baum L. In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein. Life Sci. 2010 Jun 5; 86(23-24):899-905.

[25] Zhang C, Zhang CX, He Y, Hang H. Phosphorylation sites on Tyr28 and the C-terminus of Rad9 are required for inhibition of premature chromosomal condensation across the entire S phase. Cell Physiol Biochem. 2008; 22(1-4):295-306.

[26] He W, Zhao Y, Zhang C, An L, Hu Z, Liu Y, Han L, Bi L, Xie Z, Xue P, Yang F, Hang H. Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1. Nucleic Acids Res. 2008 Nov; 36(20):6406-17.

[27] Hu Z, Liu Y, Zhang C, Zhao Y, He W, Han L, Yang L, Hopkins KM, Yang X, Lieberman HB, Hang H. Targeted deletion of Rad9 in mouse skin keratinocytes enhances genotoxin-induced tumor development. Cancer Res. 2008 Jul 15; 68(14):5552-61.

（三）专利：

1. 张春波， 关国良， 赵春芳，程研。一种含7-羟基香豆素结构基团的荧光化合物, 2022-07-12, 中国, ZL202210190982.X

2. 张春波， 关国良， 赵春芳，程研。一种含7-甲基香豆素结构基团的荧光化合物, 2022-07-15, 中国, ZL202210194958.3

3. 张春波， 关国良， 赵春芳，程研。一种含萘酰亚胺结构基团的荧光化合物, 2022-07-12, 中国, ZL202210190983.4

4. 张春波， 关国良， 赵春芳，程研。一种含7-氨基香豆素结构基团的荧光化合物, 2022-07-08, 中国, ZL202210257719.8

5. 张春波， 关国良， 赵春芳，程研。一种含7-氰基香豆素结构基团的荧光化合物, 2022-07-08, 中国, ZL202210257742.7