博士生导师

董会雷

姓名:董会雷

职称:校聘研究员

邮箱:huileidong@ncu.edu.cn

籍贯:河北石家庄

导师类型:博士生导师

主讲课程:

个人主页:课题组网站:http://www-x--mol-com-s.dxvpn.ncu.edu.cn:8118/groups/HuileiDong

研究方向

(1)多肽靶向药物的设计与开发;(2)功能性多肽组装体在生物医学中的应用;(3)自组装多肽在药物递送中的应用研究;(4)抗菌、抗炎等功能性多肽的开发与应用

教育经历

2017.09~2021.06:厦门大学,分析化学,理学博士

2014.09~2017. 06:南京师范大学,物理化学,理学硕士

2010.09~2014.06:保定学院,化学,理学学士

工作履历

2024.09~至今:南昌大学药学院/生物医学创新研究院特聘研究员

2021.07~2024.06:中国科学院大学,博士后

科研成果

承担国家自然科学基金项目、中国博士后项目等。以第一作者或通讯作者在 Journal of the American Chemical Society、Angewandte Chemie International Edition和Journal of Controlled Release等期刊上发表论文7篇。

1、 主持科研课题

[1] 国家自然科学基金青年项目,项目名称:酶促自组装抗癌肽协同化疗药物治疗骨肉瘤的研究,课题负责人:董会雷,2024.01-2026.12(30万)

[2] 中国博士后科学基金第71批面上资助,酶促多肽自组装及其在骨肉瘤治疗上的应用(编号2022M713099),课题负责人:董会雷,2022.07-2024.06(8万,已结题)

[3] 南昌大学高层次人才启动经费,项目负责人:董会雷,2024.09-2030.09

2、发表代表性论文

[1] Huilei Dong, Jinjing Li, Hongtan Liu, Shuaimin Lu, Junjie Wu, Youming Zhang, Yizhen Yin*, Yibing Zhao, Chuanliu Wu*. Design and Ribosomal Incorporation of Noncanonical Disulfide-Directing Motifs for the Development of Multicyclic Peptide Libraries. Journal of the American Chemical Society, 2022, 114: 5116-5125. (中科院一区,IF=15.4)

[2] Huilei Dong, Mingshui Wang, Shihui Fan, Chuanliu Wu, Chunhui Zhang, Xia Wu, Bin Xue, Yi Cao,Junjie Deng, Dan Yuan*, Junfeng Shi*. Redox-Regulated Conformational Change of Disulfide-Rich Assembling Peptides. Angewandte Chemie International Edition, 2022, 61: e2022128. (中科院一区,IF=16.8)

[3] Huilei Dong, Xiaoting Meng, Xiaoli Zheng, Xueting Cheng, Yiwu Zheng, Yibing Zhao, Chuanliu Wu*. Design and Synthesis of Cross-Link-Dense Peptides by Manipulating Regioselective Bisthioether Cross-Linking and Orthogonal Disulfide Pairing. The Journal of Organic Chemistry, 2019, 84: 5187-5194. (中科院二区,IF=4.7)

[4] Yuting Cai, Yatong Xiang, Huilei Dong*, Wenjing Huang, Yan Liu, Chenguang Zhao, Dan Yuan, Yun Li*, Junfeng Shi*. Injectable Self-assembling Peptide Hydrogel as a Promising Vitreous Substitute. Journal of Controlled Release, 2024. (中科院一区,IF=10.5)

[5] Huilei Dong, Hongfei Chen, Juqian Jiang, Hui Zhang, Chenxin Cai, Qingming Shen, Highly Sensitive Electrochemical Detection of Tumor Exosomes Based on Aptamer Recognition-Induced Multi-DNA Release and Cyclic Enzymatic Amplification. Analytical Chemistry, 2018, 90(7): 4507-4513. (中科院一区,IF=6.8)

Hui Zhang*, Huilei Dong, Guoqing Yang, Hongfei Chen, Chenxin Cai. Sensitive Electrochemical Detection of Human Methyltransferase Based on a Dual Signal Amplification Strategy Coupling Gold Nanoparticle-DNA Complexes with Ru (III) Redox Recycling. Analytical Chemistry, 2016, 88(22): 11108-11114. (中科院一区,IF=6.3, 导师一作)