姓名:胡萍
职称:副研究员
邮箱:canyhp@163.com
籍贯:湖北黄冈
导师类型:硕士生导师
主讲课程:转化医学研究进展
个人主页:
肿瘤发生发展的分子机制研究;重大传染性疾病的全人源单克隆抗体药物研发;脑胶质瘤和应激相关精神疾病的防治策略探索
2004.09~2008.06:湖北师范大学,生物技术专业,理学学士
2008.09~2013.06:华中科技大学,生物化学与分子生物学专业(硕博连读),理学博士
2014.07~2020.12:南昌大学转化医学研究院,助理研究员
2020.12~ 至今: 南昌大学转化医学研究院,副研究员
江西省青年科技工作者协会委员
国家科技专家库在库专家
江西省、安徽省、湖南省科技项目评审专家
Journal of Integrative Neuroscience 客座编辑及多家SCI期刊审稿人
2019年入选省级人才
2022年获得南昌大学焕奎书院医学创新实验班本科生“优秀导师”称号
2022年第八届江西省“互联网+”大学生创新创业大赛优秀创新创业导师
2023年第九届江西省“互联网+”大学生创新创业大赛优秀创新创业导师
一、 主要科研成果
先后主持国家及省部级项目8项,在国内外知名学术期刊上以第一作者或通讯作者论文15篇,最高影响因子32.086分(2篇),单篇最高引用次数320次(google scholar);申报发明专利20项,其中6项已授权。
1、 主持科研课题
[1] 胡萍. 治疗人巨细胞病毒感染的全人源单克隆抗体的筛选及其药效学验证, 国家自然科学基金地区项目, 35万, 2022.01-2025.12, 32160184.
[2] 胡萍. β-肾上腺素能受体上调MALAT1促进脑胶质瘤发生的机制研究, 国家自然科学基金地区项目, 34万元, 2018.1-2021.12, 81760505.
[3] 胡萍. 江西省“双千计划”-科技创新高端人才-青年类, 100万元, 2023.1- 2025.12.
[4] 胡萍. 肠道病毒71型全人单克隆抗体药物的研发, 江西省重点研发计划项目, 100万元, 2018.1- 2020.12, 20181ACG70003.
[5] 胡萍. 治疗丙型肝炎的全人单克隆抗体药物研发, 江西省杰出青年人才资助计划项目, 30万元, 2019.1-2021.12, 20192BCB23008.
[6] 胡萍. Acetyl-Ser-Asp-Lys-Pro(AcSDKP)调控神经胶质瘤发生及血管生成的机制研究, 江西省自然科学基金面上项目, 6万元, 2016.1- 2017.12, 20161BAB205212.
[7] 胡萍. β-肾上腺素能受体通过上调MALAT1促进脑胶质瘤发生的机制研究, 江西省自然科学基金青年项目, 6万元, 2017.1-2018.12, 20171BAB215039.
[8] 胡萍. Acetyl-Ser-Asp-Lys-Pro(AcSDKP) 调控神经胶质瘤发生的信号机制研究, 江西省教育厅科学技术研究一般项目, 3万元, 2016.1-2018.12, GJJ150195.
[9] 辛洪波, 胡萍. 肠道病毒71型全人单克隆抗体药物制备, 国家科技部重大专项重大新药创制项目, 706.38万, 2019.1-2020.12, 2019ZX09301-169.
[10] 辛洪波, 胡萍. 全人源特异性新型冠状病毒(SARS-CoV-2)单克隆抗体的制备, 浙江大学新型冠状病毒肺炎(COVID-19)应急科研专项, 50万元, 2020.2-2022.8, 2020XGZX034.
[11] 辛洪波, 胡萍. 全人源特异性抗新型冠状病毒(2019-nCov)单克隆抗体药物的研发, 南昌市新冠肺炎应急科研攻关项目, 50万元, 2020.3-2021.12, 洪科字[2020]33号-3.
2、发表代表性论文
[1] Zhiheng Zheng, Xingcheng Lin, Ying Lu, Shi-Rui Cao, Xu-Kai Liu, Dong Lin, Fan-Hua Yang, Yang-Bo Zhang, Jiang-Long Tu, Bing-Xing Pan, Ping Hu*, Wen-Hua Zhang*. Harmine exerts anxiolytic effects by regulating neuroinflammation and neuronal plasticity in the basolateral amygdala. International Immunopharmacology, 2023, 119:110208.
[2] Wen Chen, Fuhong Liu, Xingcheng Lin, Lehui Li, Wenting Chen, Tiantian Zhang, Yuwei Liu, Liyan Niu, Yangbo Zhang, Ping Hu*. Cucurbitacin E inhibits the proliferation of glioblastoma cells via FAK/AKT/GSK3β pathway Oncology Reports, 2023.
[3] Ziyan Xu, Liru Huang, Tiantian Zhang, Yuwei Liu, Fang Fang, Xinyue Wu, Wen Chen, Lingning Lan, Yangbo Zhang, Na Li*, Ping Hu*. Shikonin inhibits the proliferation of cervical cancer cells via FAK/AKT/GSK3β signalling. Oncology Letters, 2022,24(3): 304.
[4] Ping Hu#, Ying Lu#, Bing-Xing Pan, Wen-Hua Zhang*. New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder. International Journal of Molecular Sciences, 2022, 23(19):11076.
[5] Yu Liu#, Ping Hu#, Zhi-Heng Zheng, Da Zhong, Wei-Chang Xie, Zhi-Bo Tang, Bing-Xing Pan*, Jun Luo*, Wen-Hua Zhang*, Xiao-Lei Wang*. Photoresponsive Vaccine-Like CAR-M System with High- Efficiency Central Immune Regulation for Inflammation-related Depression. Advanced Materials, 2022, 34(11):e2108525.
[6] Yuge Zhu#, Yunxia Lv#, Chenyi Guo, Zhimin Xiao, Qunguang Jiang, Huang Kuang, Wenhua Zhang, Ping Hu*. Harmine inhibits the proliferation and migration of glioblastoma cells via FAK/AKT pathway. Life Sciences, 2021, 270:119112.
[7] Xia Qin#, Xiaoxuan Liu#, Yu Wang, Dan Wang, Ying Song, Jiaxin Zhou, Hanqing Pan, Xiaozhou Zhai, Yongmei Zhang, Yangbo Zhang, Ping Hu*, Wenhua Zhang*. Early life stress induces anxiety-like behavior during adulthood through dysregulation of neuronal plasticity in the basolateral amygdala. Life Sciences, 2021,285(2021)119959.
[8] Liguo Jin#, Ping Hu#, Yinyin Wang, Luojia Wu, Kang Qin, Haoxin Cheng, Shuhua Wang, Bingxing Pan, Hongbo Xin, Wenhua Zhang*, Xiaolei Wang*. Fast-Acting Black-Phosphorus-Assisted Depression Therapy with Low Toxicity. Advanced Materials, 2020,1906050(1-8).
[9] Chaochao Wei, Yu Liu, Xue Tian, Ruolei Li, Wanqing Tong, ShuhuaWang, Hongbo Xin, Ping Hu*, Xiaolei Wang*. A New Glioblastoma Targeting Therapy Concept by Using Square carrier Assisted with 3D Printed External Magnetic Wearables. Particle &Particle Systems Characterization, 2019, 36, 1800384.
[10] Yu Liu, Chaochao Wei, Long Huang, Weizhu Liu, Jiaqi Lin, Leifeng Chen, Yalan Yang, Ping Hu*, Anwen Liu *, Xiaolei Wang*. Loquat inspired Janus drug delivery system for flexible and robust tumor targeting therapy. ACS Biomaterials Science & Engineering, 2019, 5 (2), 740–747.
[11] Jingjing He, Wenhua Zhang, Shiling Liu, Yifang Chen, Chenxi Liao, Qianqing Shen, Ping Hu*. Activation of beta-adrenergic receptor promotes cell proliferation in human glioblastoma cells. Oncology Letters, 2017, 14(3):3846-3852.
[12] Ping Hu, Jingjing He, Shiling Liu, Meng Wang, Bingxing Pan, Wenhua Zhang. β2 adrenergic receptor activation promotes the proliferation of A549 lung cancer cells via ERK1/2/CREB pathway. Oncology Reports, 2016, 36(3):1757-63.
[13] Ping Hu#, Wenhua Zhang#, Hongbo Xin and Glenn Deng. Single Cell Isolation and Analysis. Frontiers in Cell and Developmental Biology, 2016,4:116.
[14] Ping Hu, Bin Li, Wenhua Zhang, Yijian Li, Guang Li, Xinnong Jiang. Joanna Wdzieczak-Bakala, Jianmiao Liu. AcSDKP regulates cell proliferation through PI3KCA/Akt signaling pathway. Plos One, 2013, 8(11): e79321.
3、主要专利:
[1] 发明专利: 刘剑峰, 张文华, 孟夏, 皮振钧, 胡萍, 孙兵. 一种细胞模型及其构建方法和在筛选抗神经紊乱性疾病药物中的应用, 中国, ZL201210394298.X(授权).
[2] 发明专利: 魏强, 胡萍, 辛洪波, 刘苏俊, 殷文曲. 一种抗体基因重组质粒的转染方法, 中国, ZL201610701207.0(授权).
[3] 发明专利: 辛洪波, 胡萍, 魏强, 刘苏俊. 一种中和肠道病毒71型的全人源单克隆抗体及其用途, 中国, ZL201810607322.0(授权).
[4] 发明专利: 胡萍, 辛洪波, 王纯艳, 刘苏俊, 张文华. 一种高亲和力抗狂犬病病毒的全人源单克隆抗体及其用途, 中国, ZL202110498615.1(授权).
[5] 发明专利: 胡萍, 辛洪波, 尧志峰, 刘苏俊, 张文华. 一种高亲和力抗丙型肝炎病毒的全人源单克隆抗体及其用途, 中国, ZL202110498647.1(授权).
[6] 发明专利: 胡萍, 辛洪波, 尧志峰, 刘苏俊. 一种单克隆抗体的筛选方法, 中国, ZL202010577866.4 (授权)