心血管药理、心肌损伤保护、线粒体功能障碍

2005.9~2008.7： 南昌大学，临床医学专业，专科学历

2008.9~2010.7： 赣南医学院，临床医学专业，医学学士

2010.9~2016.7：南昌大学，内科学，临床医学博士（硕博连续）

2012.11~2015.5： 美国波士顿大学，交流访问

2023.9~2023.12： 英国伦敦玛丽女王大学，交流访问

2016．9~至今： 南昌大学药学院药理教研室教师

 中国药理学会心血管药理专业委员会青年委员

 中国药理学会化疗专业委员会青年委员

 中国药理学会教学与科普专业委员会青年委员

 《中国临床药理学与治疗学》青年编委

 国家自然科学基金通讯评审专家

2019年南昌大学第六届教师授课竞赛一等奖

2023年入选省级人才

一、主要科研成果

主持并完成国家自然科学基金青年基金项目，主持在研国家自然科学基金地区基金项目1项；作为主要人员参加国家自然科学基金项目多项；主持完成江西省青年科学基金项目、江西省科技厅应用研究培育计划各一项。在国内外著名学术期刊发表论文36 篇（其中SCI 收录杂志31篇；通讯作者16 篇，第一作者15 篇），获中国专利一项。

1、主持科研课题：

[1] 何欢，国家自然科学青年基金项目， HSF5/HSPB7 和14-3-3η交互作用与心肌损伤保护，№: 81803534，21.5万元，2019.1~2021.12

[2] 何欢，国家自然科学地区基金项目， ADMA/DDAHⅡ/eNOS/NO 介导的阿霉素内皮毒性与铁死亡及葛根素干预机制， №:82160685，34万元，2022.1~2025.12

[3] 何欢，赣鄱俊才支持计划-主要学科学术和技术带头人培养项目--青年人才， AMPKα1线粒体定位对顺铂肾毒性损伤影响及其EGCG干预， 20232BCJ23041，30万元，2024.1~2026.12

[4] 何欢，江西省省级科技计划——“应用研究培育计划”,葛根素保护线粒体功能对抗铁过载诱发血管内皮细胞损伤， №：20181BBG78059，6万元，2018.1~2020.12

[5] 何欢，江西省自然科学基金青年项目，14-3-3η/HSF5/HSPS信号通路在心肌细胞急性缺氧/复氧损伤及其保护中的作用，№：20171BAB215077，6万元，2017.7~2020.6

2、发表代表性论文：

[1] He H#, Wang L, Qiao Y, Yang B, Yin D, He M. Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy. Redox Biol. 2021 Nov 11;48:102185.

[2] Qiao Y, Wang L, Hu T, Yin D, He H*, He M. Capsaicin protects cardiomyocytes against lipopolysaccharide-induced damage via 14-3-3γ-mediated autophagy augmentation. Front Pharmacol. 2021 Apr 27;12:659015.

[3] He H#, Wang L, Qiao Y, Zhou Q, Yang B, Yin L, Yin D, He M. Vinegar/Tetramethylpyrazine Induces Nutritional Preconditioning Protecting the Myocardium Mediated by VDAC1. Oxid Med Cell Longev. 2021 Apr 20;2021:6670088.

[4] 4.Peng Y, Wang L, Zhang Z, He X, Fan Q, Cheng X, Qiao Y, Huang H, Lai S, Wan Q, He M, He H*. Puerarin activates adaptive autophagy and protects the myocardium against doxorubicin-induced cardiotoxicity via the 14-3-3γ/PKCε pathway. Biomed Pharmacother. 2022 Sep;153:113403.

[5] Peng Y, Wang L, Zhao X, Lai S, He X, Fan Q, He H*, He M. Puerarin attenuates lipopolysaccharide-induced myocardial injury via the 14-3-3γ/PKCε pathway activating adaptive autophagy. Int Immunopharmacol. 2022 Jul;108:108905.

[6] Chen T, Niu L, Wang L, Zhou Q, Zhao X, Lai S, He X, He H*, He M. Ferulic acid protects renal tubular epithelial cells against anoxia/reoxygenation injury mediated by AMPKα1. Free Radic Res. 2022 Feb;56(2):173-184.

[7] Wang Z, Yang B, Chen X, Zhou Q, Li H, Chen S, Yin D, He H*, He M. Nobiletin Regulates ROS/ADMA/DDAHII/eNOS/NO Pathway and Alleviates Vascular Endothelium Injury by Iron Overload. Biol Trace Elem Res. 2020 Nov;198(1):87-97.

[8] Chen X, Li H, Wang Z, Zhou Q, Chen S, Yang B, Yin D, He H*, He M. Quercetin protects the vascular endothelium against iron overload damages via ROS/ADMA/DDAHⅡ/eNOS/NO pathway. Eur J Pharmacol. 2020 Feb 5;868:172885.

[9] Wu W, Yang B, Qiao Y, Zhou Q, He H*, He M. Kaempferol protects mitochondria and alleviates damages against endotheliotoxicity induced by doxorubicin. Biomed Pharmacother. 2020 Jun;126:110040.

[10] He H#, Wang L, Qiao Y, Zhou Q, Li H, Chen S, Yin D, Huang Q, He M. Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway. Front Pharmacol. 2020 Jan 10;10:1531.

[11] Yang B, Li H, Qiao Y, Zhou Q, Chen S, Yin D, He H*, He M. Tetramethylpyrazine attenuates the endotheliotoxicity and the mitochondrial dysfunction by doxorubicin via 14-3-3γ/Bcl-2. Oxid Med Cell Longev. 2019; 2019: 5820415.

[12] Luo Y, Wan Q, Xu M, Zhou Q, Chen X, Yin D, He H*, He M. Nutritional preconditioning induced by astragaloside Ⅳ on isolated hearts and cardiomyocytes against myocardial ischemia injury via improving Bcl-2- mediated mitochondrial function. Chem Biol Interact. 2019; 309:108723.

[13] Chen X, Peng X, Luo Y, You J, Yin D, Xu Q, He H*, He M. Quercetin protects cardiomyocytes against doxorubicin-induced toxicity by suppressing oxidative stress and improving mitochondrial function via 14-3-3γ. Toxicol Mech Methods. 2019; 29(5): 344-54.

[14] He H#, Qiao Y, Zhang Z, Wu Z, Liu D, Liao Z, Yin D, He M*. Dual action of vitamin C in iron supplement therapeutics for iron deficiency anemia: prevention of liver damage induced by iron overload. Food Funct, 2018, 9, 5390-401.

[15] He H#, Luo Y, Qiao Y, Zhang Z, Yin D, Yao J, You J, He M*. Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14-3-3γ. Food Funct. 2018; 9, 4404-18.

[16] Zhang ZY#, He H#, Qiao Y, Huang JY, Wu ZL, Xu P, Yin D, He M*. TanshinoneⅡA pretreatment protects H9c2 cells against anoxia/reoxygenation injury: involvement of the translocation of Bcl-2 to mitochondria mediated by 14-3-3η. Oxid Med Cell Longev. 2018; 2018: 3583921.

[17] Huang B, You J, Qiao Y, Wu Z, Liu D, Yin D, He H*, He M. Tetramethylpyrazine attenuates lipopolysaccharide-induced cardiomyocyte injury via improving mitochondrial function mediated by 14-3-3γ. Eur J Pharmacol. 2018; 832: 67-74.

[18] Liu Z, Yang L, Huang J, Xu P, Zhang Z, Yin D, Liu J, He H*, He M. Luteoloside attenuates anoxia/reoxygenation-induced cardiomyocytes injury via mitochondrial pathway mediated by 14-3-3η protein. Phytother Res. 2018; 32: 1126-34.

[19] Huang J, Liu Z, Xu P, Zhang Z, Yin D, Liu J, He H*, He M. Capsaicin prevents mitochondrial damage, protects cardiomyocytes subjected to anoxia/ reoxygenation injury mediated by 14-3-3η/Bcl-2. Eur J Pharmacol. 2018; 819: 43-50.