新型药物递送系统

1989.9~1993.7：赣南师范大学（原赣南师范学院），化学教育专业，本科/学士学位.

1996.9~1999.7：中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室，植物学专业（植物化学方向），硕士研究生/理学硕士学位.

2001.9~2005.7：沈阳药科大学，药剂学专业，博士研究生/理学博士学位.

1993.7~1996.8：江西瑞金壬田中学.

1999.10~2001.8：广东药学院药学系.

2005.8~2006.8：昆明滇虹药业有限公司.

2006.9至今：南昌大学药学院.

一、科研业绩

1．主持课题

[1] 国家自然科学基金地区科学基金项目，两亲性梳形高分子材料用于改善口服固体脂质纳米粒稳定性的研究（81560576），44万元，2016.1~2019.12.

[2] 国家自然科学基金项目地区科学基金项目，细胞转运肽和两亲性壳聚糖衍生物修饰纳米粒用于提高蛋白多肽药物口服结肠吸收的研究（81260482），50万元，2013.1~2016.12.

[3] 国家自然科学基金项目地区科学基金项目，两种细胞转运肽修饰纳米粒用于肽/蛋白质口服给药的研究（30960466），22万元，2010.1~2012.12.

[4] 江西省包干制试点示范项目，内质网膜/聚合物杂合囊泡用作口服药物载体的研究（ZBG20230418038），10万元，2023.7~2026.6.

[5] 江西省自然科学基金面上项目，两亲性梳形高分子材料用于克服口服纳米粒粘液屏障的研究（20202BAB206083），6万元，2020.7~2023.6.

[6] 江西省自然科学基金面上项目，新型口服生物粘附固体脂质纳米粒的研究（20122BAB205031），4万元，2013.1~2015.12.

[7] 江西省科技支撑计划一般项目，夏天无多囊脂质体长效制剂的研究（2007BG13105），2万元，2007.7~2010.6.

2、代表性论文

[1] Taoxing Peng, Xinyue Shao, Li Long, Han Liu, Wenqin Song, Jiazhen Hou, Haijun Zhong*, Yang Ding*, Yongzhuo Huang*. Rational design of oral delivery nanosystems for hypoglycemic peptides. Nano Today. 2023, 53: 102031.

[2] Xiang Liu, Feng Guo, Desheng Liang, Zilin Li, Yating Cao, Mengqi Chen, Jianjun Xu, Xinliang Liu, Haijun Zhong*. Development and evaluation of finasteride niosomes targeting to hair follicles for the management of androgenic alopecia. Journal of Drug Delivery Science and Technology. 2023, 86: 104725.

[3] Desheng Liang, Weipeng You, Fangfang Zhu, Jiahui Wang, Feng Guo, Jianjun Xu, Xinliang Liu, Haijun Zhong*. Targeted delivery of pexidartinib to tumor-associated macrophages via legumain-sensitive dual-coating nanoparticles for cancer immunotherapy. Colloids and Surfaces B: Biointerfaces. 2023, 226: 113283.

[4] Desheng Liang, Zujun Wen, Jiahui Wang, Fangfang Zhu, Feng Guo, Jianliang Zhou, Jianjun Xu, Haijun Zhong*. Legumain protease-sheddable PEGylated, tuftsin-modified nanoparticles for selective targeting to tumor-associated macrophages. Journal of Drug Targeting. 2022, 30(1): 82-93.

[5] Taoxing Peng, Desheng Liang, Feng Guo, Hui Peng, Yingchao Xu, Nengping Luo, Xiuying Zhang, Haijun Zhong*. Enhanced storage stability of solid lipid nanoparticles by surface modification of comb-shaped amphiphilic inulin derivatives. Colloids and Surfaces B: Biointerfaces. 2019, 181: 369-378.

[6] Feng Guo, Ting Ouyang, Taoxing Peng, Xiuying Zhang, Baogang Xie, Xiaoling Yang, Desheng Liang* and Haijun Zhong*. Enhanced oral absorption of insulin using colon-specific nanoparticles co-modified with amphiphilic chitosan derivatives and cell-penetrating peptides. Biomaterials Science. 2019, 7(4): 1493-1506.

[7] Taoxing Peng, Feng Guo, Desheng Liang, Yuan Gao, Xiuying Zhang, Suping Qiu, Jian Liu, Haijun Zhong*. Improved gastrointestinal stability of solid lipid nanoparticles using comb-shaped amphiphilic inulin derivatives. Die Pharmazie. 2019, 74 (1): 47-53.

[8] Suping Qiu, Desheng Liang, Feng Guo, Tiantian Deng, Taoxing Peng, Yuan Gao, Xiuying Zhang, Haijun Zhong*. Solid lipid nanoparticles modified with amphipathic chitosan derivatives for improved stability in the gastrointestinal tract. Journal of Drug Delivery Science and Technology. 2018, 48: 288-299.

[9] Desheng Liang, Jian Liu, Taoxing Peng, Hui Peng, Feng Guo*, Haijun Zhong*. Vitamin E-based redox-sensitive salinomycin prodrug-nanosystem with paclitaxel loaded for cancer targeted and combined chemotherapy. Colloids and Surfaces B: Biointerfaces. 2018, 172: 506-516.

[10] Wenyi Song, Yuting Yang, Miaorong Yu, Quanlei Zhu, Haijun Zhong* and Yong Gan*. Enhanced digestion inhibition and mucus penetration of F127-modified self-nanoemulsions for improved oral delivery. Asian Journal of Pharmaceutical Sciences. 2018, 13 (4): 326-335.

[11] Shuangxi Chen, Feng Guo, Tiantian Deng, Siqi Zhu, Wenyu Liu, Haijun Zhong*, Hua Yu, Rong Luo, and Zeyuan Deng. Eudragit S100 coated chitosan nanoparticles co-loading Tat for enhanced oral colon absorption of insulin. AAPS PharmSciTech. 2017, 18 (4): 1277-1287.

[12] Siqi Zhu, Shuangxi Chen, Yuan Gao, Feng Guo, Fengying Li, Baogang Xie, Jianliang Zhou, Haijun Zhong*. Enhanced oral bioavailability of insulin using PLGA nanoparticles co-modified with cell-penetrating peptides and Engrailed secretion peptide (Sec). Drug Delivery. 2016, 23 (6): 1980-1991.

[13] Feng Guo, Mengyuan Zhang, Yuan Gao, Siqi Zhu, Shuangxi Chen, Wenyu Liu, Haijun Zhong*, Jianping Liu*. Modified nanoparticles with cell-penetrating peptide and amphipathic chitosan derivative for enhanced oral colon absorption of insulin: preparation and evaluation. Drug Delivery. 2016, 23 (6): 2003-2014.

[14] Feng Guo, Haijun Zhong*, Jing He, Baogang Xie, Fen Liu, Helin Xu, Minmin Liu, Chunlian Xu. Self-microemulsifying drug delivery system for improved oral bioavailability of dipyridamole: preparation and evaluation. Archives of Pharmacal Research. 2011, 34 (7): 1113-1123.

[15] Helin Xu, Haijun Zhong*, Minmin Liu, Chunlian Xu, Yuan Gao. Lappaconitine-loaded microspheres for parenteral sustained release: effects of formulation variables and in vitro characterization. Die Pharmazie. 2011, 66 (9): 654-661.

[16] Haijun Zhong, Yingjie Deng, Xiumin Wang, Binghua Yang. Multivesicular liposome formulation for the sustained delivery of breviscapine. International Journal of Pharmaceutics. 2005, 301 (1-2): 15-24.

[17] Haijun Zhong, Yingjie Deng, Binghua Yang, Chunlei Li, Song Du. Enhanced oral bioavailability of breviscapine after encapsulation in a liposomal formulation. Die Pharmazie. 2005, 60 (6): 475-476.

[18]彭涛兴, 彭辉, 许应超, 张凡, 梁德胜, 郭锋, 钟海军*. 黏液穿透纳米递送系统克服口服吸收黏液屏障的研究进展. 中国新药杂志. 2020, 29(4): 392-398.

[19] 胡蓉, 陈双喜, 钟海军*, 余华, 罗荣, 邓泽元. 艾地苯醌固体分散体的制备及体外溶出度研究. 中国药房. 2015, 26(34): 4831-4833.

[20] 李蔚雯, 赵鹏飞, 余华, 罗荣, 邓泽元, 钟海军*. 齐墩果酸β-环糊精包合物的制备. 南昌大学学报 (医学版). 2015, 55(5): 10-13, 18.

[21] 钟海军, 邓英杰, 徐春莲, 谢宝刚. 灯盏花素的理化性质研究. 中国药房. 2013, 24 (7): 608-610.

[22] 高源, 李凤英, 刘玲, 李蔚雯, 何京, 钟海军*. 氢溴酸高乌甲素亲水凝胶骨架片的制备及体外释放. 中国现代应用药学. 2013, 30(7): 740-744.

[23] 李凤英, 何京, 钟海军*. 细胞穿透肽的研究进展. 中国新药杂志. 2013, 22 (15): 1761-1767.

[24] 刘芬, 李良, 钟海军*, 黄惠明, 郭峰, 徐春莲, 徐卫国. 夏天无总碱多囊脂质体的制备与体外特征评价. 中国药房. 2011, 22 (7): 605-607. [25] 钟海军, 邓英杰, 王丽君, 杜松, 王秀敏, 陈妍. 灯盏花素脂质体/水分配系数的研究与应用. 沈阳药科大学学报. 2005, 22 (2): 110-114. [26] 钟海军, 邓英杰. 灯盏花素新剂型研究进展. 中成药. 2005, 27 (8): 950-953.

3．参编专著

邓英杰主编, 钟海军参编.《脂质体技术》. 人民卫生出版社. 2007. 1.

二、教学业绩

1．课程建设

[1] 国家级一流本科课程（线上一流课程），药剂学，课程负责人，2023年第二批.

[2] 江西省2020年省级精品在线开放课程，药剂学，课程负责人.

[3] 江西省2019年省级虚拟仿真实验教学项目，布洛芬原料药及胶囊剂的工业生产虚拟仿真实验，项目负责人.

[4] 南昌大学2022年校级教学成果二等奖，虚拟仿真在药学实验教学中的应用，排名第一.

[5] 南昌大学2021年线上线下混合式示范课程，药剂学，课程负责人.

[6] 南昌大学2020年校级一流本科课程立项建设课程，药剂学，课程负责人.

[7] 南昌大学2019年校级精品在线开放课程，药剂学，课程负责人.

[8] 南昌大学2018年校级示范性虚拟仿真实验教学项目，布洛芬原料药及胶囊剂的工业生产虚拟仿真实验项目，项目负责人.

2．主编教材

[1] 普通高等学校“十四五”规划药学类专业特色教材，《药剂学》，华中科技大学出版社，第一主编，书号：ISBN 9787568071734，出版日期：2021年7月.