纳米生物传感器在药物分析中的应用

2015年9月-2018年6月，西南大学，分析化学，博士

2013年9月-2015年6月，西南大学，分析化学，硕士

2009年9月-2013年6月，河南理工大学，应用化学，学士

2018年7月-至今，南昌大学，药物分析教研室，讲师

主要科研成果

自2013年至今一直从事基于纳米技术和生物技术的光谱分析新方法及其在生化和药物分析方面的应用研究，相关研究成果以论文形式发表：SCI学术论文38篇，其中以第一作者和通讯作者在国际知名学术期刊如《Biosens. Bioelectron.》、《Sens. Actuator, B》、《Anal. Chim. Acta》等上发表研究论文13篇。2022年作为课题负责人主持江西省自然科学基金青年项目1项，作为主要参与者参加国家自然科学基金面上项目2项；入选2019年度“215人才工程”赣江青年学者，荣获“南昌大学第二届青年教师教学竞赛三等奖”；以参与者身份获得江西省科学技术奖二等奖一项。

1、 主持科研课题：

[1] 江西省科学技术厅, 青年基金项目, 20224BAB216116, 二维光谱阵列传感试纸同时检测中药中多农药残留研究, 2023-01 至 2025-12, 10万元, 在研, 主持

[2] 江西省中医药管理局, 一般项目, 2021A321, 基于核酸适配体及信号放大技术的双荧光传感器用于中药中多农药残留的检测, 2021-07 至 2023-12, 1万元, 在研, 主持

[3] 南昌大学医学部, 青年教师科研培育基金项目, 4209-16100009-PY201904, 多通道纸传感器在乳腺癌多标志物检测中的应用研究, 2019-12 至 2022-01, 5万元, 结题, 主持

2、发表代表性论文：

[1] [1]Guan-Ting Xu, Tian-Sheng Zhao, Kun Zhang, Li-Zhen Guo, Yong-Qin He, Jian-Hua Hu, Yi-Jing Liao, Xi Mai*, Na Li*, Smartphone assisted fluorescent sensor for Fe3+ and ascorbic acid determination based on off-on carbon dots probe, Chinese J. Anal. Chem., 2023, 51.1, 100206. (通讯作者)

[2] [2]Hui-Ting Cao, Tiansheng Zhao, Meng-Qian Liu, Li-Zhen Guo1, Yong-Qin He, Kun Zhang, Xi Mai*, Na Li*, Ratiometric optical detection of pyrophosphate based on aggregation-caused dual-signal response of gold nanoclusters, Luminescence, 2023; 38, 1458-1464. (通讯作者)

[3] [3]Li-Na Hong, Hui-Ting Cao, Yi-Xuan Feng, Li-Zhen Guo, Meng-Qian Liu, Kun Zhang, Xi Mai*, Na Li*, Aggregation-caused dual-signal response of gold nanoclusters for ratiometric optical detection of cysteine, Anal. Sci., 2023, 39, 1719–1726. (通讯作者)

[4] [4]Na Li, Yong Qing Zhong, Shi Gang Liu, Yong Qin He, Yu Zhu Fan, Jian Hua Hu, Xi Mai, Smartphone assisted colorimetric and fluorescent triple-channel signal sensor for ascorbic acid assay based on oxidase-like CoOOH nanoflakes, Spectrochim. Acta A, 2020, 238, 118412. (第一作者，通讯作者)

[5] [5]Na Li, Shi Gang Liu, Yong Qin He, Xi Mai, Resonance rayleigh scattering as a tool for isoelectric point monitoring and iron (III) cation determination, Anal. Sci., 2019, 35, 1149–1153. (第一作者，通讯作者)

[6] [6]Na Li, Xia Hao, Bei Hua Kang, Zhen Xu, Yan Shi, Nian Bing Li and Hong Qun Luo, Enzyme-free fluorescent biosensor for the detection of DNA based on core–shell Fe3O4 polydopamine nanoparticles and hybridization chain reaction amplification, Biosens. Bioelectron., 2016, 77, 525–529. (第一作者)

[7] [7]Na Li, Shi Gang Liu, Yu Die Zhu, Ting Liu, Shu Min Lin, Yan Shi, Hong Qun Luo , Nian Bing Li, Tuning gold nanoparticles growth via DNA and carbon dots for nucleic acid and protein detection, Sens. Actuators B, 2017, 251, 455–461. (第一作者)

[8] [8]Na Li, Ting Liu, Shi Gang Liu, Shu Min Lin, Yu Zhu Fan, Hong Qun Luo , Nian Bing Li, Visible and fluorescent detection of melamine in raw milk with one-step synthesized silver nanoparticles using carbon dots as the reductant and stabilizer, Sens. Actuators B, 2017, 248, 597–604. (第一作者)

[9] [9]Na Li, Shi Gang Liu, Yu Zhu Fan, Yan Jun Ju, Na Xiao, Hong Qun Luo, Nian Bing Li, Adenosine-derived doped carbon dots: from an insight into effect of N/P co-doping on emission to highly sensitive picric acid sensing, Anal. Chim. Acta, 2018, 1013, 63–70. (第一作者)

[10] [10]Na Li, Shi Gang Liu, Jiang Xue Dong, Yu Zhu Fan, Yan Jun Ju, Hong Qun Luo, Nian Bing Li, Using high-energy phosphate as energy-donor and nucleus growth-inhibitor to prepare carbon dots for hydrogen peroxide related biosensing, Sens. Actuators B, 2018, 262, 780–788. (第一作者)

[11] [11]Na Li, Zhong Feng Gao, Bei Hua Kang, Nian Bing Li, Hong Qun Luo, Sensitive mutant DNA biomarker detection based on magnetic nanoparticles and nicking endonuclease assisted fluorescence signal amplification, RSC Adv., 2015, 5, 20020–20024. (第一作者)

[12] [12]Na Li, Yu Die Zhu, Ting Liu, Shi Gang Liu, Shu Min Lin, Yan Shi, Hong Qun Luo, Nian Bing Li, Turn-on fluorescence detection of pyrophosphate anion based on DNA-attached cobalt oxyhydroxide, New J. Chem., 2017, 41, 1993–1996. (第一作者)

[13] [13]Na Li, Xia Hao, Bei Hua Kang, Nian Bing Li and Hong Qun Luo, Sensitive and selective turn-on fluorescence method for cetyltrimethylammonium bromide determination based on acridine orange-polystyrene sulfonate complex, Luminescence, 2016, 31, 1025–1030. (第一作者)

[14] [14]Shi Gang Liu, Na Li, Lei Han, Ling Jie Li, Nian Bing Li, Hong Qun Luo, Size-dependent modulation of fluorescence and light scattering: a new strategy for development of ratiometric sensing, Mater. Horiz., 2018, 5, 454–460. (第二作者)

[15] [15]Xiao Fang Zhang, Na Li, Yu Ling, Nian Bing Li, Hong Qun Luo, Sensitive detection of active uracil-DNA glycosylase via an exonuclease III-assisted cascade multi-amplification fluorescence DNA machine, Sens. Actuators B, 2018, 271, 9–14. (第二作者)

[16] [16]Xiao Fang Zhang, Na Li, Yu Ling, Li Tang, Nian Bing Li, Hong Qun Luo, Linked bridge hybridizing-induced split G-quadruplex DNA machine and its application to uracil-DNA glycosylase detection, 255, 2589–2594. (第二作者)

[17] [17]Yan Jun Ju, Na Li, Shi Gang Liu, Lei Han, Na Xiao, Hong Qun Luo, Nian Bing Li, Ratiometric fluorescence method for malachite green detection based on dual-emission BSA-protected gold nanoclusters, Sens. Actuators B, 2018, 275, 244–250. (第二作者)

[18] [18]Xiao Fang Zhang, Na Li, Cui Ye, Jia Yu Liang, Nian Bing Li, Hong Qun Luo, Sensitive label-free resonance Rayleigh scattering DNA machine-based dual amplification strategy for the active uracil-DNA glycosylase assay, Sens. Actuators B, 2017, 250, 300–306. (第二作者)

[19] [19]Shi Gang Liu, Na Li, Yu Zhu Fan, Nian Bing Li, Hong Qun Luo, Intrinsically fluorescent polymer nanoparticles for sensing Cu2+ in aqueous media and constructing an IMPLICATION logic gate, Sens. Actuators B, 2017, 43, 634–641. (第二作者)

[20] [20]Ting Liu, Na Li, Jiang Xue Dong, Ying Zhang, Yu Zhu Fan, Shu Min Lin, Hong Qun Luoa, Nian Bing Li, A colorimetric and fluorometric dual-signal sensor for arginine detection by inhibiting the growth of gold nanoparticles/carbon quantum dots composite, Biosens. Bioelectron., 2017, 87, 772–778. (第二作者)

[21] [21]Xia Hao, Na Li, Zhen Xu, Nian Bing Li, and Hong Qun Luo, An electrochemical sensing strategy for amantadine detection based on competitive host-guest interaction of methylene blue/b-cyclodextrin/poly(N-acetylaniline) modified electrode, Electroanalysis, 2016, 28, 1489–1494. (第二作者)

[22] [22]Shi Gang Liu, Na Li, Yu Ling, Bei Hua Kang, Shuo Geng, Nian Bing Li, Hong Qun Luo, pH-mediated fluorescent polymer particles and gel from hyperbranched polyethylenimine and the mechanism of intrinsic fluorescence, Langmuir, 2016, 32, 1881–1889. (第二作者)

[23] [23]Ting Liu, Na Li, Jiang Xue Dong, Hong Qun Luo, Nian Bing Li, Fluorescence detection of mercury ions and cysteine based on magnesium and nitrogen co-doped carbon quantum dots and IMPLICATION logic gate operation, Sens. Actuators B, 2016, 231, 147–153. (第二作者)

3、成果获奖：

麦曦，欧阳婷，涂国刚，贺永勤，廖一静，冯丽华，赵天生，李娜，付敏，曾祥盛，江西省科学技术进步二等奖，新型无过渡金属参与的偶联反应体系在化学药制备中的应用及产业化，2021，8/10。