过渡金属催化C-H选择性官能化反应，光催化SP3 C-H键有氧环化反应在药物合成中的应用研究

2008-09 至 2012-06, 河北工业大学, 材料化学, 学士

2012-09 至 2015-06, 兰州大学, 有机化学, 硕士

2015-09 至 2017-06, 兰州大学, 有机化学, 博士

2022-12 至 2023-12, 布里斯托大学，化学院，访问学者

2017-07 至今, 南昌大学药学院药物化学及天然药物化学教研室专任教师

江西省药学会药物化学专业委员会委员

一、 主要科研成果

长期从事过渡金属催化C-H选择性活化研究及光催化有机合成反应研究，发表相关SCI论文20余篇，其中，以通讯作者发表SCI论文3篇，以第一作者及共同第一作者发表SCI论文7篇。作为主要参与者参加国家自然科学基金面上项目3项，以第四作者获江西省科学技术奖二等奖一项。

1、 主持科研课题：

[1] 南昌大学医学部青年教师科研培育基金项目，4209-16100009-PY201810无导向基参与的喹啉及吡啶C(3)-H选择性官能化反应研究，2019/01-2021/12, 5万元，主持。

[2] 贺永勤. 基于选择性C-H活化策略构建吡啶C3官能团化拟药分子化合物库, 南昌大学创新创业课题, 0.8万元, 2019.1-2020.6, 2020CX251。

2、发表代表性论文：

[1] Wan-Fa Tian; Na Li; Zi-He Peng; Li-Hua Feng; Xi Mai; Yong-Qin He* Recent advances in ligand-Promoted transition-metal-catalyzed remote meta-C-H functionalization of arenes, Chin. J. Org. Chem., 2020, 40, 625-644.

[2] Wan-Fa Tian; Ke-Han He; Na Li; Fen Liu; Xi Mai; Li-Hua Feng; Yong-Qin He* Transition-Metal-Free coupling reactions: PPh3-Promoted Sonogashira-Type cross-couplings of heteroaryl halides with terminal alkynes, ChemistrySelect, 2020, 5, 4496-4499.

[3] Liu, Fen; Zhang, Kun.; Zhao, Xiaofei; Meng, Qinxin.; Zhao, Tiansheng.; Tian, Wanfa*; He, Yong-Qin*. Photoinduced stereoselective hydroalkylation of terminal arylalkynes via C(sp3)-H functionalization. Tetrahedron Lett. 2023, 115, 154321.

[4] Yong-Qin He; Zhaoyang Wu; Chaowei Ma; Xiaoqiang Zhou; Xingxing Liu; Xiajun Wang; Guosheng Huang* Palladium-catalyzed selective C-H activation: A simple method to synthesize C-3 site arylated quinoline derivatives, Adv. Synth. Catal., 2016, 358(3), 375-379.

[5] Yong-Qin He; Shengkang Liu; Ping Wen; Wanfa Tian; Xiaoyu Ren; Qiangxiao Zhou; Haojie Ma; Guosheng Huang* Iodine-catalyzed regioselective sulfenylation of indoles with thiols in water, ChemistrySelect, 2016, 1, 1567- 1570.

[6] Xiao-Yu Wang1, Yong-Qin He1, Yi Zhou, Lin Lu, Xian-Rong Song, Zhao-Zhao Zhou, Wan-Fa Tian,* Qiang Xiao* Photoalkylation/-arylation of ortho-Diketones with Unactivated Organic Halides, Org. Lett. 2023, 25, 3847-3852.

[7] Xiao-Yu Wang1, Yong-Qin He1, Mei Wang,a Yi Zhou,a Na Li, Xian-Rong Song, Zhao-Zhao Zhou, Wan-Fa Tian*, Qiang Xiao* Visible-light-driven proton reduction for semihydrogenation of alkynes via organophotoredox/ manganese dual catalysis, RSC Adv., 2022, 12, 36138-36141.

[8] Mei Wang1; Yong-Qin He1; Yao Zhu,; Zhi-Bin Song; Xiao-Yu Wang; Hai-Yang Huang; Ban-Peng Cao; Wan-Fa Tian*; Qiang Xiao* The wavelength-regulated stereodivergent synthesis of (Z)- and (E)-1,4-enediones from phosphonium ylides, Organic Chemistry Frontiers, 2021, 8(21), 5934-5940.

[9] Yao Zhu1; Yong-Qin He1; Wan-Fa Tian*; Mei, Wang; Zhao-Zhao Zhou; Xian-Rong Song; Hai-Xin Ding; Qiang Xiao* Dual cobalt and photoredox catalysis enabled redox-neutral annulation of 2-propynolphenols, Adv. Synth. Catal., 2021, 363(13), 3372-3377.

[10] Wan-Fa Tian1; Yong-Qin He1; Xian-Rong Song; Hai-Xin Ding; Jing Ye; Wen-Jie Guo; Qiang Xiao* cis-Selective transfer semihydrogenation of alkynes by merging visible-light catalysis with cobalt catalysis, Adv. Synth. Catal. 2020, 362, 1032-1038.

[11] Yuxing Fan; Yong-Qin He; Xingxing Liu; Ting Hu; Haojie Ma; Xiaodong Yang; Xinliang Luo; Guosheng Huang* Iodine-mediated domino oxidative cyclization: One-pot synthesis of 1,3,4-oxadiazoles via oxidative cleavage of C(sp2 )-H or C(sp)-H Bond, J. Org. Chem., 2016, 81, 6820-6825.

[12] Zhaoyang Wu; Yong-Qin He; Chaowei Ma; Xiaoqiang Zhou; Xingxing Liu; Yamin Li; Ting Hu; Ping Wen; Guosheng Huang* Oxidative remote C-H trifluoromethylation of quinolineamides on the C5 position with iodobenzene diacetate as the oxidizing agent, Asian J. Org. Chem., 2016, 5, 724-728.

[13] Xiajun Wang, Yong-Qin He; Mengdan Ren, Shengkang Liu, He Liu, and Guosheng Huang*, Pd-catalyzed Ligand-Free Synthesis of Arylated heteroaromatics by Coupling of N-heteroaromatic Bromides with Iodobenzene diacetate, Iodosobenzen or Diphenyliodonium salts, J. Org. Chem., 2016, 81, 7958.

[14] Jian Li, Yong-Qin He; Xiaoyu Ren, Xiaokang Shi, Sizhuo Yang, Xiai Gao, and Guosheng Huang*, On Water: Free Catalysis Approach for the Synthesis of Nitrones from Hydroxamic Acids and Dimethy, Chin. J. Chem., 2013, 31, 1003.

[15] Zhu, Y.; Huang, H.-Y.; Yong-Qin He; Wang, M.; Wang, X.-Y.; Song, X.-R.; Mao, Z.-J.; Tian, W.-F*.; Xiao, Q. Visible-light enabled photochemical reduction of 1,2-dicarbonyl compounds by H眉nig's base. Org. Chem. Front. 2022, 9, 1924-1931.

[16] Tian, W.-F.; Zhu, Y.; Yong-Qin He; Wang, M.; Song, X.-R.; Bai, J.; Xiao, Q*. Hydroxyl Assisted, Photoredox/Cobalt Co-catalyzed Semi-Hydrogenation and Tandem Cyclization of o-Alkynylphenols for Access to 2,3-Dihydrobenzofurans. Adv. Synth. Catal. 2021, 363, 730-736.

[17] Xingxing Liu, Zhaoyang Wu, Yong-Qin He; Xiaoqiang Zhou, Ting Hu, Chaowei Ma, and Guosheng Huang*, Copper-Catalyzed C-N Bond Formation via Oxidative Cross-Coupling of Amines with 伪-Amino Carbonyl Compounds, Adv. Synth. Catal., 2016, 358, 2385.

[18] Xiaoqiang Zhou, Hao Yan, Chaowei Ma, Yong-Qin He; Yamin Li, Jinhui Cao, Rulong Yan*, and Guosheng Huang*, Copper-Mediated Aerobic Oxidative Synthesis of 3 Bromoimidazo[1,2 a]pyridines with Pyridines and Enamides, J. Org. Chem., 2016, 81, 25.

[19] Xingxing Liu, Zhaoyang Wu, Xinliang Luo, Yong-Qin He; Xiaoqiang Zhou, and Guosheng Huang*, PhI(OAc)2 Oxidative C(5) Halogenation of Quinolines Using Copper Halides Under Mild Conditions, RSC Adv., 2016, 6, 71485.

[20] Yamin Li, Xiaoqiang Zhou, Zhaoyang Wu, Jinhui Cao, Chaowei Ma, Yong-Qin He; and Guosheng Huang*, Metal free synthesis of 2,4-diarylquinoline derivatives with enamides and imines, RSC Adv., 2015, 5, 88214.

[21] Haojie Ma, Xiaoyu Ren, Xiaoqiang Zhou, Chaowei Ma, Yong-Qin He; and Guosheng Huang*, Palladium and copper co-catalyzed Markovnikov hydrothiolation of terminal olefins and alkynes, Tetrahedron Lett., 2015, 56, 6022.